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Structure, Function, and Mechanism of the Nickel Metalloenzymes, CO Dehydrogenase, and Acetyl-CoA Synthase

Chemical reviews, 2014-04, Vol.114 (8), p.4149-4174

2014

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Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

Cell, 2017-04, Vol.169 (2), p.258-272.e17

2017

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IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats

Journal of neuroinflammation, 2018-02, Vol.15 (1), p.32-32, Article 32

2018

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Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

Cell, 2013-08, Vol.154 (3), p.556-568

2013

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Structural plasticity of D3–D14 ubiquitin ligase in strigolactone signalling

Nature (London), 2018-11, Vol.563 (7733), p.652-656

2018

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Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Nucleic acids research, 2022-02, Vol.50 (3), p.1484-1500

2022

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An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

The Journal of biological chemistry, 2009-03, Vol.284 (12), p.8023-8032

2009

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1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors

Biochemical journal, 2024-08, Vol.481 (16), p.1075-1096

2024

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Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy

Circulation research, 2007-03, Vol.100 (6), p.914-922

2007

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Development of Inhibitors of the 2C‑Methyl‑d‑erythritol 4‑Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.9740-9763

2014

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Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo

Biochemical pharmacology, 2022-03, Vol.197, p.114932-114932, Article 114932

2022

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Targeting human SET1/MLL family of proteins

Protein science, 2017-04, Vol.26 (4), p.662-676

2017

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Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells

PLoS genetics, 2020-11, Vol.16 (11), p.e1009117

2020

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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Nature medicine, 2009-07, Vol.15 (7), p.781-787

2009

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A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation

The Journal of pharmacology and experimental therapeutics, 2010-07, Vol.334 (1), p.310-317

2010

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AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

The Journal of biological chemistry, 2006-11, Vol.281 (46), p.34870-34879

2006

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Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy

Proceedings of the National Academy of Sciences - PNAS, 2021-09, Vol.118 (39), p.1

2021

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Endocrine disruptors of inhibiting testicular 3β-hydroxysteroid dehydrogenase

Chemico-biological interactions, 2019-04, Vol.303, p.90-97

2019

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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Cell metabolism, 2005-07, Vol.2 (1), p.9-19

2005

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Fungal acetyltransferases structures, mechanisms and inhibitors: A review

International journal of biological macromolecules, 2020-08, Vol.157, p.626-640

2020

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Identification of ATIC as a Novel Target for Chemoradiosensitization

International journal of radiation oncology, biology, physics, 2018-01, Vol.100 (1), p.162-173

2018

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Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (12), p.E2319-E2326

2017

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Mechanisms of resistance of malaria parasites to antifolates

Pharmacological reviews, 2005-03, Vol.57 (1), p.117-145

2005

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Acephate interferes with androgen synthesis in rat immature Leydig cells

Chemosphere (Oxford), 2020-04, Vol.245, p.125597-125597, Article 125597

2020

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Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

PLoS medicine, 2007-06, Vol.4 (6), p.e206-e206

2007

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Structure, Function, and Mechanism of the Nickel Metalloenzymes, CO Dehydrogenase, and Acetyl-CoA Synthase

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats

Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

Structural plasticity of D3–D14 ubiquitin ligase in strigolactone signalling

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors

Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy

Development of Inhibitors of the 2C‑Methyl‑d‑erythritol 4‑Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents

Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo

Targeting human SET1/MLL family of proteins

Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy

Endocrine disruptors of inhibiting testicular 3β-hydroxysteroid dehydrogenase

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Fungal acetyltransferases structures, mechanisms and inhibitors: A review

Identification of ATIC as a Novel Target for Chemoradiosensitization

Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis

Mechanisms of resistance of malaria parasites to antifolates

Acephate interferes with androgen synthesis in rat immature Leydig cells

Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

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