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Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs

Journal of enzyme inhibition and medicinal chemistry, 2016-11, Vol.31 (sup1), p.177-183

2016

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Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia

Journal of medicinal chemistry, 2016-09, Vol.59 (18), p.8189-8206

2016

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Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition

Nature materials, 2014-06, Vol.13 (6), p.653-661

2014

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Is there new hope for therapeutic matrix metalloproteinase inhibition?

Nature reviews. Drug discovery, 2014-12, Vol.13 (12), p.904-927

2014

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N‑O‑Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7224-7240

2015

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Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions

Journal of cellular physiology, 2016-12, Vol.231 (12), p.2599-2621

2016

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Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor

Journal of molecular biology, 2023-07, Vol.435 (13), p.168095, Article 168095

2023

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Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

The Journal of biological chemistry, 2017-10, Vol.292 (43), p.17963-17974

2017

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Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

The Journal of biological chemistry, 2017-02, Vol.292 (8), p.3481-3495

2017

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Development of a selective matrix metalloproteinase 13 (MMP-13) inhibitor for the treatment of Osteoarthritis

European journal of medicinal chemistry, 2021-11, Vol.224, p.113666-113666, Article 113666

2021

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Is dual inhibition of metalloenzymes HDAC-8 and MMP-2 a potential pharmacological target to combat hematological malignancies?

Pharmacological research, 2017-08, Vol.122, p.8-19

2017

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The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

Cells (Basel, Switzerland), 2019-08, Vol.8 (9), p.984

Fields, Gregg B

2019

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Recent advancement of piperidine moiety in treatment of cancer- A review

European journal of medicinal chemistry, 2018-09, Vol.157, p.480-502

2018

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Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

The Journal of biological chemistry, 2019-06, Vol.294 (24), p.9476-9488

2019

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Targeted MMP-2 responsive chimeric polymersomes for therapy against colorectal cancer

Colloids and surfaces, B, Biointerfaces, 2020-09, Vol.193, p.111135, Article 111135

2020

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Outline of gelatinase inhibitors as anti-cancer agents: A patent mini-review for 2010-present

European journal of medicinal chemistry, 2021-03, Vol.213, p.113044-113044, Article 113044

2021

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Regulation of matrix metalloproteinases 2 and 9 in corneal neovascularization

Chemical biology & drug design, 2020-05, Vol.95 (5), p.485-492

2020

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Small molecular exogenous modulators of active forms of MMPs

Biochimie, 2024-08, Vol.223, p.125-132

2024

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Recent Research Advances in Selective Matrix Metalloproteinase‐13 Inhibitors as Anti‐Osteoarthritis Agents

ChemMedChem, 2017-08, Vol.12 (15), p.1157-1168

2017

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New in Vivo Compatible Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitors

Bioconjugate chemistry, 2018-11, Vol.29 (11), p.3715-3725

2018

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Challenges in Matrix Metalloproteinases Inhibition

Biomolecules (Basel, Switzerland), 2020-05, Vol.10 (5), p.717

2020

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Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors

Bioorganic & medicinal chemistry, 2013-11, Vol.21 (21), p.6456-6465

2013

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Computational design of matrix metalloprotenaise-9 (MMP-9) resistant to auto-cleavage

Biochemical journal, 2023-07, Vol.480 (14), p.1097-1107

2023

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Therapeutic Targeting of MMP-12 for the Treatment of Chronic Obstructive Pulmonary Disease

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12911-12920

2020

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Carbodiimide Inactivation of MMPs and Effect on Dentin Bonding

Journal of dental research, 2014-03, Vol.93 (3), p.263-268

2014

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Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs

Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia

Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition

Is there new hope for therapeutic matrix metalloproteinase inhibition?

N‑O‑Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity

Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions

Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

Development of a selective matrix metalloproteinase 13 (MMP-13) inhibitor for the treatment of Osteoarthritis

Is dual inhibition of metalloenzymes HDAC-8 and MMP-2 a potential pharmacological target to combat hematological malignancies?

The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

Recent advancement of piperidine moiety in treatment of cancer- A review

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

Targeted MMP-2 responsive chimeric polymersomes for therapy against colorectal cancer

Outline of gelatinase inhibitors as anti-cancer agents: A patent mini-review for 2010-present

Regulation of matrix metalloproteinases 2 and 9 in corneal neovascularization

Small molecular exogenous modulators of active forms of MMPs

Recent Research Advances in Selective Matrix Metalloproteinase‐13 Inhibitors as Anti‐Osteoarthritis Agents

New in Vivo Compatible Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitors

Challenges in Matrix Metalloproteinases Inhibition

Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors

Computational design of matrix metalloprotenaise-9 (MMP-9) resistant to auto-cleavage

Therapeutic Targeting of MMP-12 for the Treatment of Chronic Obstructive Pulmonary Disease

Carbodiimide Inactivation of MMPs and Effect on Dentin Bonding

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