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The MEKK1-MKK1/MKK2-MPK4 Kinase Cascade Negatively Regulates Immunity Mediated by a Mitogen-Activated Protein Kinase Kinase Kinase in Arabidopsis

The Plant cell, 2012-05, Vol.24 (5), p.2225-2236

2012

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MAP2K1 and MAP3K1 mutations in langerhans cell histiocytosis

Genes chromosomes & cancer, 2015-06, Vol.54 (6), p.361-368

2015

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RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point

Nature communications, 2019-04, Vol.10 (1), p.1897-17, Article 1897

2019

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Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling

Nature cell biology, 2020-04, Vol.22 (4), p.389-400

2020

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Langerhans cell histiocytosis: A neoplastic disorder driven by Ras-ERK pathway mutations

Journal of the American Academy of Dermatology, 2018-03, Vol.78 (3), p.579-590.e4

2018

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Deletion of a Tandem Gene Family in Arabidopsis: Increased MEKK2 Abundance Triggers Autoimmunity when the MEKK1-MKK1/2-MPK4 Signaling Cascade Is Disrupted

The Plant cell, 2013-05, Vol.25 (5), p.1895-1910

2013

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Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes

Nature (London), 2019-11, Vol.575 (7783), p.545-550

2019

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Optical control of cell signaling by single-chain photoswitchable kinases

Science (American Association for the Advancement of Science), 2017-02, Vol.355 (6327), p.836-842

2017

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Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling

Cancer research (Chicago, Ill.), 2018-06, Vol.78 (11), p.3041-3053

2018

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Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition

Oncogene, 2017-06, Vol.36 (23), p.3334-3345

2017

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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

Cancer cell, 2020-06, Vol.37 (6), p.834-849.e13

2020

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Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

Nature genetics, 2012-02, Vol.44 (2), p.133-139

2012

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Mechanisms and strategies to overcome resistance to molecularly targeted therapy for melanoma

Cancer, 2017-06, Vol.123 (S11), p.2118-2129

2017

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MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models

Cell research, 2018-07, Vol.28 (7), p.719-729

2018

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Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

Cancer cell, 2014-05, Vol.25 (5), p.697-710

2014

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IL‐17 alters the mesenchymal stem cell niche towards osteogenesis in cooperation with osteocytes

Journal of cellular physiology, 2020-05, Vol.235 (5), p.4466-4480

2020

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Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer

Oncogene, 2019-06, Vol.38 (25), p.5076-5090

2019

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MEK1/2 dual-specificity protein kinases: Structure and regulation

Biochemical and biophysical research communications, 2012-01, Vol.417 (1), p.5-10

Roskoski, Robert

2012

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c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma

Cancer cell, 2011-05, Vol.19 (5), p.652-663

2011

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Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

The Journal of clinical investigation, 2018-04, Vol.128 (4), p.1496-1508

2018

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Inducible Pluripotent Stem Cell–Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome

Circulation (New York, N.Y.), 2019-07, Vol.140 (3), p.207-224

2019

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A Cardiac-enriched MicroRNA, miR-378, Blocks Cardiac Hypertrophy by Targeting Ras Signaling

The Journal of biological chemistry, 2013-04, Vol.288 (16), p.11216-11232

2013

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ROS mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose metabolism in pancreatic cancer

Biochemical and biophysical research communications, 2018-06, Vol.500 (4), p.873-878

2018

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Patient-derived models of acquired resistance can identify effective drug combinations for cancer

Science (American Association for the Advancement of Science), 2014-12, Vol.346 (6216), p.1480-1486

2014

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Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212

Molecular cancer therapeutics, 2012-03, Vol.11 (3), p.720-729

2012

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The MEKK1-MKK1/MKK2-MPK4 Kinase Cascade Negatively Regulates Immunity Mediated by a Mitogen-Activated Protein Kinase Kinase Kinase in Arabidopsis

MAP2K1 and MAP3K1 mutations in langerhans cell histiocytosis

RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point

Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling

Langerhans cell histiocytosis: A neoplastic disorder driven by Ras-ERK pathway mutations

Deletion of a Tandem Gene Family in Arabidopsis: Increased MEKK2 Abundance Triggers Autoimmunity when the MEKK1-MKK1/2-MPK4 Signaling Cascade Is Disrupted

Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes

Optical control of cell signaling by single-chain photoswitchable kinases

Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling

Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition

SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

Mechanisms and strategies to overcome resistance to molecularly targeted therapy for melanoma

MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

IL‐17 alters the mesenchymal stem cell niche towards osteogenesis in cooperation with osteocytes

Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer

MEK1/2 dual-specificity protein kinases: Structure and regulation

c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Inducible Pluripotent Stem Cell–Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome

A Cardiac-enriched MicroRNA, miR-378, Blocks Cardiac Hypertrophy by Targeting Ras Signaling

ROS mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose metabolism in pancreatic cancer

Patient-derived models of acquired resistance can identify effective drug combinations for cancer

Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212

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