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Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

Autophagy, 2019-04, Vol.15 (4), p.631-651

2019

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Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (28), p.E3699-E3708

2015

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Molecular mechanisms of ferroptosis and its role in cancer therapy

Journal of cellular and molecular medicine, 2019-08, Vol.23 (8), p.4900-4912

2019

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Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

Nature communications, 2017-09, Vol.8 (1), p.548-13, Article 548

2017

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Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

The Journal of biological chemistry, 2016-04, Vol.291 (17), p.9218-9232

2016

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Regulation of mTORC1 by PI3K signaling

Trends in cell biology, 2015-09, Vol.25 (9), p.545-555

2015

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Structure of human lysosomal acid α-glucosidase–a guide for the treatment of Pompe disease

Nature communications, 2017-10, Vol.8 (1), p.1111-10, Article 1111

2017

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Galectins Control mTOR in Response to Endomembrane Damage

Molecular cell, 2018-04, Vol.70 (1), p.120-135.e8

2018

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Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

Biochemical journal, 2011-11, Vol.439 (3), p.349-378

2011

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The relationship between glucocerebrosidase mutations and Parkinson disease

Journal of neurochemistry, 2016-10, Vol.139 (S1), p.77-90

2016

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AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

Molecular cell, 2020-03, Vol.77 (5), p.951-969.e9

2020

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Phosphatidylinositol‐3‐phosphate in the regulation of autophagy membrane dynamics

The FEBS journal, 2017-05, Vol.284 (9), p.1267-1278

2017

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Disorders of lysosomal acidification—the emerging role of v-ATPase in aging and neurodegenerative disease

Ageing research reviews, 2016-12, Vol.32, p.75-88

2016

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Lysosomal cell death at a glance

Journal of cell science, 2013-05, Vol.126 (Pt 9), p.1905-1912

2013

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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

Biochimica et biophysica acta. Proteins and proteomics, 2020-08, Vol.1868 (8), p.140428-140428, Article 140428

2020

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Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia

Autophagy, 2019-03, Vol.15 (3), p.493-509

2019

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Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

Human molecular genetics, 2015-11, Vol.24 (21), p.6013-6028

2015

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Mast cell secretory granules: armed for battle

Nature reviews. Immunology, 2014-07, Vol.14 (7), p.478-494

2014

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A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion

Cell, 2015-06, Vol.161 (6), p.1306-1319

2015

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Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer

Cancer cell, 2016-09, Vol.30 (3), p.418-431

2016

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The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

Cell metabolism, 2014-09, Vol.20 (3), p.526-540

2014

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Lysosomal adaptation: How cells respond to lysosomotropic compounds

PloS one, 2017-03, Vol.12 (3), p.e0173771-e0173771

2017

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mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Nature (London), 2017-01, Vol.541 (7636), p.228-232

2017

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Caspase‐1 as a multifunctional inflammatory mediator: noncytokine maturation roles

Journal of leukocyte biology, 2016-11, Vol.100 (5), p.961-967

2016

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Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy

The Journal of neuroscience, 2011-05, Vol.31 (21), p.7817-7830

2011

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Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

Molecular mechanisms of ferroptosis and its role in cancer therapy

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

Regulation of mTORC1 by PI3K signaling

Structure of human lysosomal acid α-glucosidase–a guide for the treatment of Pompe disease

Galectins Control mTOR in Response to Endomembrane Damage

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

The relationship between glucocerebrosidase mutations and Parkinson disease

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

Phosphatidylinositol‐3‐phosphate in the regulation of autophagy membrane dynamics

Disorders of lysosomal acidification—the emerging role of v-ATPase in aging and neurodegenerative disease

Lysosomal cell death at a glance

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

Mast cell secretory granules: armed for battle

A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion

Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

Lysosomal adaptation: How cells respond to lysosomotropic compounds

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Caspase‐1 as a multifunctional inflammatory mediator: noncytokine maturation roles

Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy

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