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A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45

Molecular cell, 2017-08, Vol.67 (3), p.498-511.e6

2017

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Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events

The Journal of immunology (1950), 2010-02, Vol.184 (3), p.1436-1444

2010

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Conformational states of the kinase Lck regulate clustering in early T cell signaling

Nature immunology, 2013-01, Vol.14 (1), p.82-89

2013

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Exploration of the therapeutic aspects of Lck: A kinase target in inflammatory mediated pathological conditions

Biomedicine & pharmacotherapy, 2018-12, Vol.108, p.1565-1571

2018

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How does T cell receptor clustering impact on signal transduction?

Journal of cell science, 2019-02, Vol.132 (4)

2019

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De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

Science signaling, 2017-01, Vol.10 (462)

2017

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Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK

Journal of clinical immunology, 2024-01, Vol.44 (1), p.4, Article 4

2024

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The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell–specific adapter protein

The Journal of biological chemistry, 2019-10, Vol.294 (42), p.15480-15494

2019

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PALM imaging and cluster analysis of protein heterogeneity at the cell surface

Journal of biophotonics, 2010-07, Vol.3 (7), p.446-454

2010

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Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases

Science signaling, 2015-12, Vol.8 (405), p.rs13

2015

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LCK is an important mediator of B-cell receptor signaling in chronic lymphocytic leukemia cells

Molecular cancer research, 2013-05, Vol.11 (5), p.541-554

2013

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Centrosome docking at the immunological synapse is controlled by Lck signaling

The Journal of cell biology, 2011-02, Vol.192 (4), p.663-674

2011

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Negative Regulation of Lck by Cbl Ubiquitin Ligase

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (6), p.3794-3799

2002

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TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells

The Journal of immunology (1950), 2002-09, Vol.169 (6), p.2997-3005

2002

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Ezrin is a substrate for Lck in T cells

FEBS letters, 2003-01, Vol.535 (1-3), p.82-86

2003

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Cutting Edge: CD28 and c-Rel-Dependent Pathways Initiate Regulatory T Cell Development

The Journal of immunology (1950), 2010-04, Vol.184 (8), p.4074-4077

2010

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Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling

Science signaling, 2011-09, Vol.4 (190), p.ra59

2011

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Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef

The Journal of biological chemistry, 2018-05, Vol.293 (20), p.7824-7840

2018

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Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers

Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (40), p.10094-10099

2018

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MAL protein controls protein sorting at the supramolecular activation cluster of human T lymphocytes

The Journal of immunology (1950), 2011-06, Vol.186 (11), p.6345-6356

2011

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Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Nature immunology, 2020-08, Vol.21 (8), p.902-913

2020

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Evaluation of Known Defective Signaling-Associated Molecules in Patients Who Primarily Diagnosed as Common Variable Immunodeficiency

International reviews of immunology, 2016-01, Vol.35 (1), p.7-24

2016

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CD45 functions as a signaling gatekeeper in T cells

Science signaling, 2019-10, Vol.12 (604)

2019

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Lck is a key target of imatinib and dasatinib in T-cell activation

Leukemia, 2010-04, Vol.24 (4), p.896-900

2010

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Initiation of T cell signaling by CD45 segregation at 'close contacts'

Nature immunology, 2016-05, Vol.17 (5), p.574-582

2016

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A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45

Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events

Conformational states of the kinase Lck regulate clustering in early T cell signaling

Exploration of the therapeutic aspects of Lck: A kinase target in inflammatory mediated pathological conditions

How does T cell receptor clustering impact on signal transduction?

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK

The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell–specific adapter protein

PALM imaging and cluster analysis of protein heterogeneity at the cell surface

Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases

LCK is an important mediator of B-cell receptor signaling in chronic lymphocytic leukemia cells

Centrosome docking at the immunological synapse is controlled by Lck signaling

Negative Regulation of Lck by Cbl Ubiquitin Ligase

TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells

Ezrin is a substrate for Lck in T cells

Cutting Edge: CD28 and c-Rel-Dependent Pathways Initiate Regulatory T Cell Development

Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling

Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef

Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers

MAL protein controls protein sorting at the supramolecular activation cluster of human T lymphocytes

Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Evaluation of Known Defective Signaling-Associated Molecules in Patients Who Primarily Diagnosed as Common Variable Immunodeficiency

CD45 functions as a signaling gatekeeper in T cells

Lck is a key target of imatinib and dasatinib in T-cell activation

Initiation of T cell signaling by CD45 segregation at 'close contacts'

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