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Lopinavir pharmacokinetics in COVID-19 patients

Journal of antimicrobial chemotherapy, 2020-09, Vol.75 (9), p.2702-2704

2020

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Effect of Systemic Inflammatory Response to SARS-CoV-2 on Lopinavir and Hydroxychloroquine Plasma Concentrations

Antimicrobial agents and chemotherapy, 2020-08, Vol.64 (9)

2020

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Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC–MS/MS method in human serum

Journal of pharmaceutical and biomedical analysis, 2021-03, Vol.196, p.113935-113935, Article 113935

2021

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Safety of hydroxychloroquine and darunavir or lopinavir in COVID-19 infection

Journal of antimicrobial chemotherapy, 2021-01, Vol.76 (2), p.482-486

2021

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Plasma Concentrations and Safety of Lopinavir/Ritonavir in COVID-19 Patients

Therapeutic drug monitoring, 2021-02, Vol.43 (1), p.131-135

2021

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Long-Acting Profile of 4 Drugs in 1 Anti-HIV Nanosuspension in Nonhuman Primates for 5 Weeks After a Single Subcutaneous Injection

Journal of pharmaceutical sciences, 2018-07, Vol.107 (7), p.1787-1790

2018

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Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID‐19

British journal of clinical pharmacology, 2021-03, Vol.87 (3), p.1547-1553

2021

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Development and in vivo evaluation of child-friendly lopinavir/ritonavir pediatric granules utilizing novel in situ self-assembly nanoparticles

Journal of controlled release, 2016-03, Vol.226, p.88-97

2016

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Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation

Journal of controlled release, 2018-04, Vol.275, p.229-241

2018

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Pharmacokinetics and Safety of Zidovudine, Lamivudine, and Lopinavir/Ritonavir in HIV-infected Children With Severe Acute Malnutrition in Sub-Saharan Africa: IMPAACT Protocol P1092

The Pediatric infectious disease journal, 2021-05, Vol.40 (5), p.446-452

2021

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Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies

Nature communications, 2016-10, Vol.7 (1), p.13184-10, Article 13184

2016

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Pharmacokinetics of lopinavir/ritonavir oral solution to treat COVID-19 in mechanically ventilated ICU patients

Journal of antimicrobial chemotherapy, 2020-09, Vol.75 (9), p.2657-2660

2020

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Efavirenz and Lopinavir Levels in HIV-Infected Women and Their Nursing Infants, in Mali

The Journal of pharmacology and experimental therapeutics, 2018-09, Vol.366 (3), p.479-484

2018

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Salting-out assisted liquid-liquid extraction for bioanalysis

Bioanalysis, 2013-06, Vol.5 (12), p.1583-1598

2013

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Impact of Single Nucleotide Polymorphisms on Plasma Concentrations of Efavirenz and Lopinavir/Ritonavir in Chinese Children Infected with the Human Immunodeficiency Virus

Pharmacotherapy, 2017-09, Vol.37 (9), p.1073-1080

2017

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Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro

Virologica Sinica, 2020-12, Vol.35 (6), p.776-784

2020

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Novel Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Detection of Anti-HIV Drugs Lopinavir, Ritonavir, and Tenofovir in Plasma

Antimicrobial agents and chemotherapy, 2014-05, Vol.58 (5), p.2675-2680

2014

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Development and validation of a cost‐effective and sensitive bioanalytical HPLC‐UV method for determination of lopinavir in rat and human plasma

Biomedical chromatography, 2020-11, Vol.34 (11), p.e4934-n/a

2020

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No Need for Lopinavir Dose Adjustment during Pregnancy: a Population Pharmacokinetic and Exposure-Response Analysis in Pregnant and Nonpregnant HIV-Infected Subjects

Antimicrobial agents and chemotherapy, 2016-01, Vol.60 (1), p.400-408

2016

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Physiologically Based Pharmacokinetic Modeling for Predicting the Effect of Intrinsic and Extrinsic Factors on Darunavir or Lopinavir Exposure Coadministered With Ritonavir

Journal of clinical pharmacology, 2017-10, Vol.57 (10), p.1295-1304

2017

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Determination of total and unbound concentrations of lopinavir in plasma using liquid chromatography–tandem mass spectrometry and ultrafiltration methods

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014-08, Vol.965, p.216-223

2014

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Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children

The Pediatric infectious disease journal, 2016-12, Vol.35 (12), p.e378-e383

2016

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Therapeutic drug monitoring of boosted PIs in HIV-positive patients: undetectable plasma concentrations and risk of virological failure

Journal of antimicrobial chemotherapy, 2017-06, Vol.72 (6), p.1741-1744

2017

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Sex Differences in Lopinavir and Ritonavir Pharmacokinetics Among HIV-Infected Women and Men

Journal of clinical pharmacology, 2011-12, Vol.51 (12), p.1665-1673

2011

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Assessment of lamivudine, zidovudine, lopinavir, and ritonavir plasma levels in HIV-positive pregnant women: Drug monitoring application to improve patient safety

Medicine (Baltimore), 2020-05, Vol.99 (22), p.e20487

2020

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Lopinavir pharmacokinetics in COVID-19 patients

Effect of Systemic Inflammatory Response to SARS-CoV-2 on Lopinavir and Hydroxychloroquine Plasma Concentrations

Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC–MS/MS method in human serum

Safety of hydroxychloroquine and darunavir or lopinavir in COVID-19 infection

Plasma Concentrations and Safety of Lopinavir/Ritonavir in COVID-19 Patients

Long-Acting Profile of 4 Drugs in 1 Anti-HIV Nanosuspension in Nonhuman Primates for 5 Weeks After a Single Subcutaneous Injection

Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID‐19

Development and in vivo evaluation of child-friendly lopinavir/ritonavir pediatric granules utilizing novel in situ self-assembly nanoparticles

Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation

Pharmacokinetics and Safety of Zidovudine, Lamivudine, and Lopinavir/Ritonavir in HIV-infected Children With Severe Acute Malnutrition in Sub-Saharan Africa: IMPAACT Protocol P1092

Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies

Pharmacokinetics of lopinavir/ritonavir oral solution to treat COVID-19 in mechanically ventilated ICU patients

Efavirenz and Lopinavir Levels in HIV-Infected Women and Their Nursing Infants, in Mali

Salting-out assisted liquid-liquid extraction for bioanalysis

Impact of Single Nucleotide Polymorphisms on Plasma Concentrations of Efavirenz and Lopinavir/Ritonavir in Chinese Children Infected with the Human Immunodeficiency Virus

Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro

Novel Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Detection of Anti-HIV Drugs Lopinavir, Ritonavir, and Tenofovir in Plasma

Development and validation of a cost‐effective and sensitive bioanalytical HPLC‐UV method for determination of lopinavir in rat and human plasma

No Need for Lopinavir Dose Adjustment during Pregnancy: a Population Pharmacokinetic and Exposure-Response Analysis in Pregnant and Nonpregnant HIV-Infected Subjects

Physiologically Based Pharmacokinetic Modeling for Predicting the Effect of Intrinsic and Extrinsic Factors on Darunavir or Lopinavir Exposure Coadministered With Ritonavir

Determination of total and unbound concentrations of lopinavir in plasma using liquid chromatography–tandem mass spectrometry and ultrafiltration methods

Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children

Therapeutic drug monitoring of boosted PIs in HIV-positive patients: undetectable plasma concentrations and risk of virological failure

Sex Differences in Lopinavir and Ritonavir Pharmacokinetics Among HIV-Infected Women and Men

Assessment of lamivudine, zidovudine, lopinavir, and ritonavir plasma levels in HIV-positive pregnant women: Drug monitoring application to improve patient safety

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