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Nuclear receptors and nonalcoholic fatty liver disease

Biochimica et biophysica acta, 2016-09, Vol.1859 (9), p.1083-1099

2016

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Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

Immunity (Cambridge, Mass.), 2019-10, Vol.51 (4), p.638-654.e9

2019

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Ursolic Acid, a Novel Liver X Receptor α (LXRα) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis

Journal of agricultural and food chemistry, 2018-11, Vol.66 (44), p.11647-11662

2018

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Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

Nature medicine, 2018-03, Vol.24 (3), p.304-312

2018

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Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (7)

2022

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Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)

Scientific reports, 2021-04, Vol.11 (1), p.8002-23, Article 8002

2021

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Changes in LXR signaling influence early-pregnancy lipogenesis and protect against dysregulated fetoplacental lipid homeostasis

American journal of physiology: endocrinology and metabolism, 2017-10, Vol.313 (4), p.E463-E472

2017

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Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

Nature communications, 2018-04, Vol.9 (1), p.1393-14, Article 1393

2018

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The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease

Pharmacology & therapeutics (Oxford), 2018-01, Vol.181, p.1-12

Fessler, Michael B

2018

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25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism[S]

Journal of lipid research, 2018-03, Vol.59 (3), p.439-451

2018

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Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes

Hepatology (Baltimore, Md.), 2020-12, Vol.72 (6), p.1935-1948

2020

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Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors

European journal of medicinal chemistry, 2020-11, Vol.206, p.112793, Article 112793

2020

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Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist

Free radical biology & medicine, 2017-12, Vol.113, p.291-303

2017

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Morin, a novel liver X receptor α/β dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty liver diseases

British journal of pharmacology, 2017-09, Vol.174 (18), p.3032-3044

2017

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Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells

International journal of molecular sciences, 2020-12, Vol.21 (24), p.9622

2020

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Relationships of Liver X Receptor Antagonists and Atherosclerosis in Drinking Water from Six Chinese Major Cities

Environmental science & technology, 2023-12, Vol.57 (48), p.19374-19382

2023

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Liver X Receptors Regulate Cholesterol Metabolism and Immunity in Hepatic Nonparenchymal Cells

International journal of molecular sciences, 2019-10, Vol.20 (20), p.5045

2019

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LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA‐378 Transcription and Inhibition of Ppargc1β Expression

Hepatology (Baltimore, Md.), 2019-04, Vol.69 (4), p.1488-1503

2019

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Liver X receptor activation promotes differentiation of regulatory T cells

PloS one, 2017-09, Vol.12 (9), p.e0184985-e0184985

2017

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The Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells

Endocrinology (Philadelphia), 2022-07, Vol.163 (7), p.1

2022

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Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice

Endocrinology (Philadelphia), 2018-03, Vol.159 (3), p.1419-1432

2018

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Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c

Biochemical and biophysical research communications, 2017-01, Vol.482 (4), p.720-726

2017

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Once and for all, LXRα and LXRβ are gatekeepers of the endocrine system

Molecular aspects of medicine, 2016-06, Vol.49, p.31-46

2016

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Clinical relevance of cholesterol homeostasis genes in colorectal cancer

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019-10, Vol.1864 (10), p.1314-1327

2019

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Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation

Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (28), p.E6556-E6565

2018

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Nuclear receptors and nonalcoholic fatty liver disease

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

Ursolic Acid, a Novel Liver X Receptor α (LXRα) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)

Changes in LXR signaling influence early-pregnancy lipogenesis and protect against dysregulated fetoplacental lipid homeostasis

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism[S]

Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes

Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors

Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist

Morin, a novel liver X receptor α/β dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty liver diseases

Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells

Relationships of Liver X Receptor Antagonists and Atherosclerosis in Drinking Water from Six Chinese Major Cities

Liver X Receptors Regulate Cholesterol Metabolism and Immunity in Hepatic Nonparenchymal Cells

LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA‐378 Transcription and Inhibition of Ppargc1β Expression

Liver X receptor activation promotes differentiation of regulatory T cells

The Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells

Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice

Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c

Once and for all, LXRα and LXRβ are gatekeepers of the endocrine system

Clinical relevance of cholesterol homeostasis genes in colorectal cancer

Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation

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