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Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

European journal of medicinal chemistry, 2021-12, Vol.225, p.113804-113804, Article 113804

2021

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Lipid peroxidation in cell death

Biochemical and biophysical research communications, 2017-01, Vol.482 (3), p.419-425

2017

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Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

The FASEB journal, 2019-05, Vol.33 (5), p.6140-6153

2019

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Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies

Scientific reports, 2023-05, Vol.13 (1), p.8656-27, Article 8656

2023

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First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis

Arteriosclerosis, thrombosis, and vascular biology, 2017-10, Vol.37 (10), p.1828-1839

2017

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Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes

Bioorganic & medicinal chemistry, 2020-04, Vol.28 (7), p.115403-115403, Article 115403

2020

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Neutrophils support lung colonization of metastasis-initiating breast cancer cells

Nature (London), 2015-12, Vol.528 (7582), p.413-417

2015

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Antioxidant and Anti-Inflammatory Activities of Hydrolysates and Peptide Fractions Obtained by Enzymatic Hydrolysis of Selected Heat-Treated Edible Insects

Nutrients, 2017-09, Vol.9 (9), p.970

2017

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Thiazoles and Thiazolidinones as COX/LOX Inhibitors

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.685

2018

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Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis

Journal of natural products (Washington, D.C.), 2017-04, Vol.80 (4), p.999-1006

2017

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Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study

European journal of medicinal chemistry, 2016-11, Vol.123, p.803-813

2016

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Exploring the 2'-Hydroxy-Chalcone Framework for the Development of Dual Antioxidant and Soybean Lipoxygenase Inhibitory Agents

Molecules (Basel, Switzerland), 2021-05, Vol.26 (9), p.2777

2021

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Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity

Bioorganic & medicinal chemistry, 2009-12, Vol.17 (23), p.8073-8085

2009

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CAFs shape myeloid‐derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5‐lipoxygenase

Hepatology (Baltimore, Md.), 2022-01, Vol.75 (1), p.28-42

2022

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Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15-Lipoxygenase inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.847-863

2020

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Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death

Biochemical pharmacology, 2017-09, Vol.140, p.41-52

2017

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In vitro 5-LOX inhibitory and antioxidant potential of isoxazole derivatives

PloS one, 2024-10, Vol.19 (10), p.e0297398

2024

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Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2

Bioorganic & medicinal chemistry, 2021-09, Vol.46, p.116349-116349, Article 116349

2021

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Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR

European journal of medicinal chemistry, 2016-08, Vol.118, p.250-258

2016

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Synthesis and Antioxidant Activity of N -Benzyl-2-[4-(aryl)-1 H -1,2,3-triazol-1-yl]ethan-1-imine Oxides

International journal of molecular sciences, 2024-06, Vol.25 (11), p.5908

2024

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Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications

Pharmacology & therapeutics (Oxford), 2019-03, Vol.195, p.100-110

2019

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Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts

European journal of medicinal chemistry, 2009-07, Vol.44 (7), p.3020-3026

2009

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Mechanistic evaluation of a novel cyclohexenone derivative’s functionality against nociception and inflammation: An in-vitro, in-vivo and in-silico approach

European journal of pharmacology, 2021-07, Vol.902, p.174091, Article 174091

2021

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GC-MS analysis, antimicrobial, antioxidant, antilipoxygenase and cytotoxic activities of Jacaranda mimosifolia methanol leaf extracts and fractions

PloS one, 2020-07, Vol.15 (7), p.e0236319

2020

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Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

European journal of medicinal chemistry, 2018-08, Vol.156, p.534-553

2018

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Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

Lipid peroxidation in cell death

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies

First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis

Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

Antioxidant and Anti-Inflammatory Activities of Hydrolysates and Peptide Fractions Obtained by Enzymatic Hydrolysis of Selected Heat-Treated Edible Insects

Thiazoles and Thiazolidinones as COX/LOX Inhibitors

Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis

Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study

Exploring the 2'-Hydroxy-Chalcone Framework for the Development of Dual Antioxidant and Soybean Lipoxygenase Inhibitory Agents

Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity

CAFs shape myeloid‐derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5‐lipoxygenase

Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15-Lipoxygenase inhibitors

Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death

In vitro 5-LOX inhibitory and antioxidant potential of isoxazole derivatives

Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2

Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR

Synthesis and Antioxidant Activity of N -Benzyl-2-[4-(aryl)-1 H -1,2,3-triazol-1-yl]ethan-1-imine Oxides

Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications

Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts

Mechanistic evaluation of a novel cyclohexenone derivative’s functionality against nociception and inflammation: An in-vitro, in-vivo and in-silico approach

GC-MS analysis, antimicrobial, antioxidant, antilipoxygenase and cytotoxic activities of Jacaranda mimosifolia methanol leaf extracts and fractions

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

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