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Levonorgestrel-releasing intrauterine system use is associated with a decreased risk of ovarian and endometrial cancer, without increased risk of breast cancer. Results from the NOWAC Study

Gynecologic oncology, 2018-04, Vol.149 (1), p.127-132

2018

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Unintended Pregnancies Observed With Combined Use of the Levonorgestrel Contraceptive Implant and Efavirenz-based Antiretroviral Therapy: A Three-Arm Pharmacokinetic Evaluation Over 48 Weeks

Clinical infectious diseases, 2016-03, Vol.62 (6), p.675-682

2016

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Levonorgestrel‐releasing intrauterine system and breast cancer risk: A systematic review and meta‐analysis

Acta obstetricia et gynecologica Scandinavica, 2020-08, Vol.99 (8), p.970-982

2020

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Pharmacokinetics of two low-dose levonorgestrel-releasing intrauterine systems and effects on ovulation rate and cervical function: pooled analyses of phase II and III studies

Fertility and sterility, 2014-06, Vol.101 (6), p.1656-1662.e4

2014

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Progestogen-releasing intrauterine systems for heavy menstrual bleeding

Cochrane database of systematic reviews, 2020-06, Vol.6 (6), p.CD002126-CD002126

2020

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Should progesterone and estrogen receptors be assessed for predicting the response to conservative treatment of endometrial hyperplasia and cancer? A systematic review and meta‐analysis

Acta obstetricia et gynecologica Scandinavica, 2019-08, Vol.98 (8), p.976-987

2019

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ACOG Clinical Consensus No. 3: General Approaches to Medical Management of Menstrual Suppression: Correction

Obstetrics and gynecology (New York. 1953), 2024-01, Vol.143 (1), p.e20-e20

2024

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A 3-year multicentre randomized controlled trial of etonogestrel- and levonorgestrel-releasing contraceptive implants, with non-randomized matched copper-intrauterine device controls

Human reproduction (Oxford), 2015-11, Vol.30 (11), p.2527-2538

2015

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Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis

The Lancet (British edition), 2010-02, Vol.375 (9714), p.555-562

2010

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Progesterone or progestogen-releasing intrauterine systems for heavy menstrual bleeding

Cochrane database of systematic reviews, 2015-04 (4), p.CD002126-CD002126

2015

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Pharmacokinetics, pharmacodynamics, safety and tolerability of an intravaginal ring releasing anastrozole and levonorgestrel in healthy premenopausal women: a Phase 1 randomized controlled trial

Human reproduction (Oxford), 2016-08, Vol.31 (8), p.1713-1722

2016

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Contraceptive efficacy and safety of the 52-mg levonorgestrel intrauterine system for up to 8 years: findings from the Mirena Extension Trial

American journal of obstetrics and gynecology, 2022-12, Vol.227 (6), p.873.e1-873.e12

2022

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Levonorgestrel-releasing intra-uterine systems as female contraceptives

Expert opinion on pharmacotherapy, 2018-05, Vol.19 (7), p.677-686

2018

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Levonorgestrel causes feminization and dose-dependent masculinization in medaka fish (Oryzias latipes): Endocrine-disruption activity and its correlation with sex reversal

The Science of the total environment, 2023-06, Vol.876, p.162740-162740, Article 162740

2023

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Hormone-related side effects in new users of a levonorgestrel 52-mg intrauterine device

American journal of obstetrics and gynecology, 2024-07

2024

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Extended use up to 5 years of the etonogestrel-releasing subdermal contraceptive implant: comparison to levonorgestrel-releasing subdermal implant

Human reproduction (Oxford), 2016-11, Vol.31 (11), p.2491-2498

2016

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Extended use of levonorgestrel-releasing intrauterine system (LNG-IUS) 52 mg: A population pharmacokinetic approach to estimate in vivo levonorgestrel release rates and systemic exposure including comparison with two other LNG-IUSs

Contraception (Stoneham), 2023-04, Vol.120, p.109954, Article 109954

2023

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HIV incidence among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: a randomised, multicentre, open-label trial

The Lancet (British edition), 2019-07, Vol.394 (10195), p.303-313

2019

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Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen

Cochrane database of systematic reviews, 2020-12, Vol.12 (2), p.CD007245

2020

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Repeated exposure to physiologically effective doses of contraceptive hormones ethinyl estradiol or levonorgestrel do not alter the reinforcing effects of a brief visual stimulus in ovary-intact rats

Hormones and behavior, 2024-05, Vol.161, p.105506-105506, Article 105506

2024

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Interventions for emergency contraception

Cochrane database of systematic reviews, 2019-01, Vol.1 (1), p.CD001324

2019

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From single chemicals to mixtures—Reproductive effects of levonorgestrel and ethinylestradiol on the fathead minnow

Aquatic toxicology, 2015-12, Vol.169, p.152-167

2015

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The Effect of Age, Parity and Body Mass Index on the Efficacy, Safety, Placement and User Satisfaction Associated With Two Low-Dose Levonorgestrel Intrauterine Contraceptive Systems: Subgroup Analyses of Data From a Phase III Trial

PloS one, 2015-09, Vol.10 (9), p.e0135309-e0135309

2015

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Quantitative levonorgestrel plasma level measurements in patients with regular and prolonged use of the levonorgestrel-releasing intrauterine system

Contraception (Stoneham), 2012-10, Vol.86 (4), p.345-349

2012

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Levonorgestrel-releasing intrauterine system use is associated with a decreased risk of ovarian and endometrial cancer, without increased risk of breast cancer. Results from the NOWAC Study

Unintended Pregnancies Observed With Combined Use of the Levonorgestrel Contraceptive Implant and Efavirenz-based Antiretroviral Therapy: A Three-Arm Pharmacokinetic Evaluation Over 48 Weeks

Levonorgestrel‐releasing intrauterine system and breast cancer risk: A systematic review and meta‐analysis

Pharmacokinetics of two low-dose levonorgestrel-releasing intrauterine systems and effects on ovulation rate and cervical function: pooled analyses of phase II and III studies

Progestogen-releasing intrauterine systems for heavy menstrual bleeding

Should progesterone and estrogen receptors be assessed for predicting the response to conservative treatment of endometrial hyperplasia and cancer? A systematic review and meta‐analysis

ACOG Clinical Consensus No. 3: General Approaches to Medical Management of Menstrual Suppression: Correction

A 3-year multicentre randomized controlled trial of etonogestrel- and levonorgestrel-releasing contraceptive implants, with non-randomized matched copper-intrauterine device controls

Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis

Progesterone or progestogen-releasing intrauterine systems for heavy menstrual bleeding

Pharmacokinetics, pharmacodynamics, safety and tolerability of an intravaginal ring releasing anastrozole and levonorgestrel in healthy premenopausal women: a Phase 1 randomized controlled trial

Contraceptive efficacy and safety of the 52-mg levonorgestrel intrauterine system for up to 8 years: findings from the Mirena Extension Trial

Levonorgestrel-releasing intra-uterine systems as female contraceptives

Levonorgestrel causes feminization and dose-dependent masculinization in medaka fish (Oryzias latipes): Endocrine-disruption activity and its correlation with sex reversal

Hormone-related side effects in new users of a levonorgestrel 52-mg intrauterine device

Extended use up to 5 years of the etonogestrel-releasing subdermal contraceptive implant: comparison to levonorgestrel-releasing subdermal implant

Extended use of levonorgestrel-releasing intrauterine system (LNG-IUS) 52 mg: A population pharmacokinetic approach to estimate in vivo levonorgestrel release rates and systemic exposure including comparison with two other LNG-IUSs

HIV incidence among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: a randomised, multicentre, open-label trial

Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen

Repeated exposure to physiologically effective doses of contraceptive hormones ethinyl estradiol or levonorgestrel do not alter the reinforcing effects of a brief visual stimulus in ovary-intact rats

Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women

Interventions for emergency contraception

From single chemicals to mixtures—Reproductive effects of levonorgestrel and ethinylestradiol on the fathead minnow

The Effect of Age, Parity and Body Mass Index on the Efficacy, Safety, Placement and User Satisfaction Associated With Two Low-Dose Levonorgestrel Intrauterine Contraceptive Systems: Subgroup Analyses of Data From a Phase III Trial

Quantitative levonorgestrel plasma level measurements in patients with regular and prolonged use of the levonorgestrel-releasing intrauterine system

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