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The functionally relevant site for paxilline inhibition of BK channels

Proceedings of the National Academy of Sciences - PNAS, 2020-01, Vol.117 (2), p.1021-1026

2020

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Prion protein prevents the inhibition of large-conductance calcium-activated potassium channel by Tau peptide K18 oligomers

Biochemical and biophysical research communications, 2024-11, Vol.734, p.150793, Article 150793

2024

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Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism

The Journal of general physiology, 2014-11, Vol.144 (5), p.415-440

2014

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Cryo‐EM structure of the Slo1 potassium channel with the auxiliary γ1 subunit suggests a mechanism for depolarization‐independent activation

FEBS letters, 2024-04, Vol.598 (8), p.875-888

2024

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Structural mapping of patient-associated KCNMA1 gene variants

Biophysical journal, 2024-07, Vol.123 (14), p.1984-2000

2024

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Multiple Cholesterol Recognition/Interaction Amino Acid Consensus (CRAC) Motifs in Cytosolic C Tail of Slo1 Subunit Determine Cholesterol Sensitivity of Ca2+- and Voltage-gated K+ (BK) Channels

The Journal of biological chemistry, 2012-06, Vol.287 (24), p.20509-20521

2012

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alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel

Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (25), p.9313-9318

2014

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Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy

Nature (London), 2009-09, Vol.461 (7261), p.292-295

2009

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Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6328), p.924-924

2017

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Molecular mechanism of pharmacological activation of BK channels

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (9), p.3552-3557

2012

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Ion sensing in the RCK1 domain of BK channels

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (43), p.18700-18705

2010

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Atomic determinants of BK channel activation by polyunsaturated fatty acids

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (48), p.13905-13910

2016

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Aromatic interactions with membrane modulate human BK channel activation

eLife, 2020-06, Vol.9

2020

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Properties of Slo1 K⁺ channels with and without the gating ring

Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (41), p.16657-16662

2013

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Activation of Calcium- and Voltage-gated Potassium Channels of Large Conductance by Leukotriene B4

The Journal of biological chemistry, 2014-12, Vol.289 (51), p.35314-35325

2014

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β1-subunit–induced structural rearrangements of the Ca2+- and voltage-activated K⁺ (BK) channel

Proceedings of the National Academy of Sciences - PNAS, 2016-06, Vol.113 (23), p.E3231-E3239

2016

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A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid

The Journal of general physiology, 2013-11, Vol.142 (5), p.507-522

2013

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Fluorogenic Green-Inside Red-Outside (GIRO) Labeling Approach Reveals Adenylyl Cyclase-Dependent Control of BKα Surface Expression

Bioconjugate chemistry, 2015-09, Vol.26 (9), p.1963-1971

2015

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Structural Determinants of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Regulation of BK Channel Activity through the RCK1 Ca2+ Coordination Site

The Journal of biological chemistry, 2014-07, Vol.289 (27), p.18860-18872

2014

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The unique N-terminal sequence of the BKCa channel α-subunit determines its modulation by β-subunits

PloS one, 2017-07, Vol.12 (7), p.e0182068-e0182068

2017

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Functional and structural analysis of the human SLO3 pH- and voltage-gated K⁺ channel

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (47), p.19274-19279

2012

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An Improved Method for Modeling Voltage-Gated Ion Channels at Atomic Accuracy Applied to Human Ca v Channels

Cell reports (Cambridge), 2018-05, Vol.23 (5), p.1399

2018

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Structural Basis for Calcium and Magnesium Regulation of a Large Conductance Calcium-activated Potassium Channel with β1 Subunits

The Journal of biological chemistry, 2014-06, Vol.289 (24), p.16914-16923

2014

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Large-conductance Ca 2+ - and voltage-gated K + channels form and break interactions with membrane lipids during each gating cycle

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (17), p.8591-8596

2019

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The functionally relevant site for paxilline inhibition of BK channels

Prion protein prevents the inhibition of large-conductance calcium-activated potassium channel by Tau peptide K18 oligomers

Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism

Cryo‐EM structure of the Slo1 potassium channel with the auxiliary γ1 subunit suggests a mechanism for depolarization‐independent activation

Structural mapping of patient-associated KCNMA1 gene variants

Multiple Cholesterol Recognition/Interaction Amino Acid Consensus (CRAC) Motifs in Cytosolic C Tail of Slo1 Subunit Determine Cholesterol Sensitivity of Ca2+- and Voltage-gated K+ (BK) Channels

De novo loss-of-function KCNMA1 variants are associated with a new multiple malformation syndrome and a broad spectrum of developmental and neurological phenotypes

alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel

Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

Molecular mechanism of pharmacological activation of BK channels

Ion sensing in the RCK1 domain of BK channels

Atomic determinants of BK channel activation by polyunsaturated fatty acids

Aromatic interactions with membrane modulate human BK channel activation

Properties of Slo1 K⁺ channels with and without the gating ring

Activation of Calcium- and Voltage-gated Potassium Channels of Large Conductance by Leukotriene B4

β1-subunit–induced structural rearrangements of the Ca2+- and voltage-activated K⁺ (BK) channel

A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid

Fluorogenic Green-Inside Red-Outside (GIRO) Labeling Approach Reveals Adenylyl Cyclase-Dependent Control of BKα Surface Expression

Structural Determinants of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Regulation of BK Channel Activity through the RCK1 Ca2+ Coordination Site

The unique N-terminal sequence of the BKCa channel α-subunit determines its modulation by β-subunits

Functional and structural analysis of the human SLO3 pH- and voltage-gated K⁺ channel

An Improved Method for Modeling Voltage-Gated Ion Channels at Atomic Accuracy Applied to Human Ca v Channels

Structural Basis for Calcium and Magnesium Regulation of a Large Conductance Calcium-activated Potassium Channel with β1 Subunits

Large-conductance Ca 2+ - and voltage-gated K + channels form and break interactions with membrane lipids during each gating cycle

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