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Depot Medroxyprogesterone Acetate and the Vaginal Microbiome as Modifiers of Tenofovir Diphosphate and Lamivudine Triphosphate Concentrations in the Female Genital Tract of Ugandan Women: Implications for Tenofovir Disoproxil Fumarate/Lamivudine in Preexposure Prophylaxis

Clinical infectious diseases, 2020-04, Vol.70 (8), p.1717-1724

2020

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Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase

Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (17), p.7734-7739

2010

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Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol

DNA repair, 2017-01, Vol.49, p.51-59

2017

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Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens

Journal of acquired immune deficiency syndromes (1999), 2005-08, Vol.39 (4), p.406-411

2005

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Synthesis and Biological Evaluation of Fatty Acyl Ester Derivatives of (−)-2′,3′-Dideoxy-3′-thiacytidine

Journal of medicinal chemistry, 2012-05, Vol.55 (10), p.4861-4871

2012

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Molecular Modeling and Biochemical Characterization Reveal the Mechanism of Hepatitis B Virus Polymerase Resistance to Lamivudine (3TC) and Emtricitabine (FTC)

Journal of Virology, 2001-05, Vol.75 (10), p.4771-4779

2001

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Pharmacokinetic Modeling of Lamivudine and Zidovudine Triphosphates Predicts Differential Pharmacokinetics in Seminal Mononuclear Cells and Peripheral Blood Mononuclear Cells

Antimicrobial agents and chemotherapy, 2015-10, Vol.59 (10), p.6395-6401

2015

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Pharmacokinetics of Lamivudine and Lamivudine-Triphosphate after Administration of 300 Milligrams and 150 Milligrams Once Daily to Healthy Volunteers: Results of the ENCORE 2 Study

Antimicrobial Agents and Chemotherapy, 2012-03, Vol.56 (3), p.1427-1433

2012

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A general approach to the synthesis of 5-S-functionalized pyrimidine nucleosides and their analogues

Organic & biomolecular chemistry, 2014-08, Vol.12 (30), p.5634-5644

2014

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Differential Incorporation and Removal of Antiviral Deoxynucleotides by Human DNA Polymerase γ

The Journal of biological chemistry, 2001-06, Vol.276 (26), p.23616-23623

2001

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Effect of HIV-1 Infection and Sex on the Cellular Pharmacology of the Antiretroviral Drugs Zidovudine and Lamivudine

Antimicrobial Agents and Chemotherapy, 2012-06, Vol.56 (6), p.3011-3019

2012

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Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals

AIDS (London), 2003-10, Vol.17 (15), p.2159-2168

2003

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Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells

Journal of mass spectrometry., 2008-02, Vol.43 (2), p.224-233

2008

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Molecular Mechanism by Which the K70E Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Resistance to Nucleoside Reverse Transcriptase Inhibitors

Antimicrobial Agents and Chemotherapy, 2007-01, Vol.51 (1), p.48-53

2007

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Joint Population Pharmacokinetic Analysis of Zidovudine, Lamivudine, and Their Active Intracellular Metabolites in HIV Patients

Antimicrobial Agents and Chemotherapy, 2011-07, Vol.55 (7), p.3423-3431

2011

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Determinants of Individual Variation in Intracellular Accumulation of Anti-HIV Nucleoside Analog Metabolites

Antimicrobial Agents and Chemotherapy, 2011-02, Vol.55 (2), p.895-903

2011

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Lamivudine-PEGylated chitosan: a novel effective nanosized antiretroviral agent

Current HIV research, 2013-06, Vol.11 (4), p.309-320

2013

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Organic cation transporters OCT1 and OCT2 determine the accumulation of lamivudine in CD4 cells of HIV-infected patients

Infection, 2013-04, Vol.41 (2), p.379-385

2013

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Synthesis, anti-HIV and antitubercular activities of lamivudine prodrugs

European journal of medicinal chemistry, 2005-12, Vol.40 (12), p.1373-1376

2005

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Insights into the Molecular Mechanism of Mitochondrial Toxicity by AIDS Drugs

The Journal of biological chemistry, 2001-06, Vol.276 (26), p.23832-23837

2001

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Concentrations of zidovudine-and lamivudine-triphosphate according to cell type in HIV-seronegative adults

AIDS (London), 2007-09, Vol.21 (14), p.1849-1854

2007

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New Dinucleoside Phosphonate Derivatives as Prodrugs of 3′-Azido-3′-Deoxythymidine and β-L-2′,3′-Dideoxy-3′-Thiacytidine: Synthesis and Anti-HIV Properties

Nucleosides, nucleotides & nucleic acids, 2014-02, Vol.33 (2), p.64-79

2014

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Synthesis and anti-HIV activity of novel 2′,3′-dideoxy-3′-thiacytidine prodrugs

Bioorganic & medicinal chemistry, 2009-09, Vol.17 (17), p.6407-6413

2009

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Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons

AIDS (London), 2000-09, Vol.14 (14), p.2137-2144

2000

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Theoretical Studies on the Water-Assisted Hydrolysis of N,N-Dimethyl-N′-(2′,3′-dideoxy-3′-thiacytidine) Formamidine with Three Water Molecules

The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 2009-01, Vol.113 (1), p.325-331

2009

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Depot Medroxyprogesterone Acetate and the Vaginal Microbiome as Modifiers of Tenofovir Diphosphate and Lamivudine Triphosphate Concentrations in the Female Genital Tract of Ugandan Women: Implications for Tenofovir Disoproxil Fumarate/Lamivudine in Preexposure Prophylaxis

Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase

Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol

Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens

Synthesis and Biological Evaluation of Fatty Acyl Ester Derivatives of (−)-2′,3′-Dideoxy-3′-thiacytidine

Molecular Modeling and Biochemical Characterization Reveal the Mechanism of Hepatitis B Virus Polymerase Resistance to Lamivudine (3TC) and Emtricitabine (FTC)

Pharmacokinetic Modeling of Lamivudine and Zidovudine Triphosphates Predicts Differential Pharmacokinetics in Seminal Mononuclear Cells and Peripheral Blood Mononuclear Cells

Pharmacokinetics of Lamivudine and Lamivudine-Triphosphate after Administration of 300 Milligrams and 150 Milligrams Once Daily to Healthy Volunteers: Results of the ENCORE 2 Study

A general approach to the synthesis of 5-S-functionalized pyrimidine nucleosides and their analogues

Differential Incorporation and Removal of Antiviral Deoxynucleotides by Human DNA Polymerase γ

Effect of HIV-1 Infection and Sex on the Cellular Pharmacology of the Antiretroviral Drugs Zidovudine and Lamivudine

Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals

Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells

Molecular Mechanism by Which the K70E Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Resistance to Nucleoside Reverse Transcriptase Inhibitors

Joint Population Pharmacokinetic Analysis of Zidovudine, Lamivudine, and Their Active Intracellular Metabolites in HIV Patients

Determinants of Individual Variation in Intracellular Accumulation of Anti-HIV Nucleoside Analog Metabolites

Lamivudine-PEGylated chitosan: a novel effective nanosized antiretroviral agent

Organic cation transporters OCT1 and OCT2 determine the accumulation of lamivudine in CD4 cells of HIV-infected patients

Synthesis, anti-HIV and antitubercular activities of lamivudine prodrugs

Insights into the Molecular Mechanism of Mitochondrial Toxicity by AIDS Drugs

Concentrations of zidovudine-and lamivudine-triphosphate according to cell type in HIV-seronegative adults

New Dinucleoside Phosphonate Derivatives as Prodrugs of 3′-Azido-3′-Deoxythymidine and β-L-2′,3′-Dideoxy-3′-Thiacytidine: Synthesis and Anti-HIV Properties

Synthesis and anti-HIV activity of novel 2′,3′-dideoxy-3′-thiacytidine prodrugs

Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons

Theoretical Studies on the Water-Assisted Hydrolysis of N,N-Dimethyl-N′-(2′,3′-dideoxy-3′-thiacytidine) Formamidine with Three Water Molecules

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