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Distinct anti-dyskinetic effects of amantadine and group II metabotropic glutamate receptor agonist LY354740 in a rodent model: An electrophysiological perspective

Neurobiology of disease, 2020-06, Vol.139, p.104807, Article 104807

2020

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Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: The impact of cell differentiation state

Neuropharmacology, 2014-08, Vol.83, p.36-53

2014

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Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs

Pharmacology & therapeutics (Oxford), 2007-07, Vol.115 (1), p.116-147

2007

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Novel pharmacological treatments for generalized anxiety disorder: Pediatric considerations

Depression and anxiety, 2020-08, Vol.37 (8), p.747-759

2020

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Efficacy and Tolerability of an mGlu2 3 Agonist in the Treatment of Generalized Anxiety Disorder

Neuropsychopharmacology (New York, N.Y.), 2008-06, Vol.33 (7), p.1603-1610

2008

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The influence of ionotropic and metabotropic glutamate receptor ligands on anxiety-like effect of amphetamine withdrawal in rats

Progress in neuro-psychopharmacology & biological psychiatry, 2013-08, Vol.45, p.242-249

2013

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A role for nucleus accumbens glutamate in the expression but not the induction of behavioural sensitization to ethanol

Behavioural brain research, 2018-01, Vol.336, p.269-281

2018

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Comparison of the mGlu5 receptor positive allosteric modulator ADX47273 and the mGlu2/3 receptor agonist LY354740 in tests for antipsychotic-like activity

European journal of pharmacology, , Vol.623 (1-3), p.73-83

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Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2

Neuropharmacology, 2016-12, Vol.111, p.253-265

2016

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Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation

Neurochemistry international, 2015-09, Vol.88, p.124-137

2015

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Group II Metabotropic Glutamate Receptors Modulate Sound Evoked and Spontaneous Activity in the Mouse Inferior Colliculus

eNeuro, 2021-01, Vol.8 (1), p.ENEURO.0328-20.2020

2021

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Metabotropic glutamate receptors in the control of mood disorders

CNS & neurological disorders drug targets, 2007-04, Vol.6 (2), p.87

2007

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The neuroprotective effects of orthosteric agonists of group II and III mGluRs in primary neuronal cell cultures are dependent on developmental stage

Neuropharmacology, 2016-12, Vol.111, p.195-211

2016

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Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2

Neuropharmacology, 2017-03, Vol.115, p.115-127

2017

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Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators

British journal of pharmacology, 2011-09, Vol.164 (2b), p.521-537

2011

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Asymmetric Sulfonium Ylide Mediated Cyclopropanation: Stereocontrolled Synthesis of (+)-LY354740

Chemistry : a European journal, 2005-12, Vol.12 (2), p.568-575

2005

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Metabotropic glutamate2/3 receptor agonism facilitates autonomic recovery after pharmacological panic challenge in healthy humans

International clinical psychopharmacology, 2016-05, Vol.31 (3), p.176

2016

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Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

Psychopharmacologia, 2003-08, Vol.168 (4), p.446-454

2003

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Delayed treatments with pharmacological modulators of pre- and postsynaptic mGlu receptors rescue the hippocampus from kainate-induced neurodegeneration

Neuroscience letters, 2014-06, Vol.570, p.5-9

2014

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Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice

Psychopharmacology, 2005-04, Vol.179 (1), p.284-291

2005

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Glutamate-based anxiolytic ligands in clinical trials

Expert opinion on investigational drugs, 2013-08, Vol.22 (8), p.1007-1022

2013

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LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress

Stress (Amsterdam, Netherlands), 2003, Vol.6 (3), p.189-197

2003

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Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition

Behavioural pharmacology, 2009-02, Vol.20 (1), p.56

2009

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Synthesis and characterization of 1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6969-6974

2010

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Distinct anti-dyskinetic effects of amantadine and group II metabotropic glutamate receptor agonist LY354740 in a rodent model: An electrophysiological perspective

Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: The impact of cell differentiation state

Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs

Novel pharmacological treatments for generalized anxiety disorder: Pediatric considerations

Efficacy and Tolerability of an mGlu2 3 Agonist in the Treatment of Generalized Anxiety Disorder

The influence of ionotropic and metabotropic glutamate receptor ligands on anxiety-like effect of amphetamine withdrawal in rats

A role for nucleus accumbens glutamate in the expression but not the induction of behavioural sensitization to ethanol

Comparison of the mGlu5 receptor positive allosteric modulator ADX47273 and the mGlu2/3 receptor agonist LY354740 in tests for antipsychotic-like activity

Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2

Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation

Group II Metabotropic Glutamate Receptors Modulate Sound Evoked and Spontaneous Activity in the Mouse Inferior Colliculus

Metabotropic glutamate receptors in the control of mood disorders

The neuroprotective effects of orthosteric agonists of group II and III mGluRs in primary neuronal cell cultures are dependent on developmental stage

Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2

Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators

Asymmetric Sulfonium Ylide Mediated Cyclopropanation: Stereocontrolled Synthesis of (+)-LY354740

Metabotropic glutamate2/3 receptor agonism facilitates autonomic recovery after pharmacological panic challenge in healthy humans

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

Delayed treatments with pharmacological modulators of pre- and postsynaptic mGlu receptors rescue the hippocampus from kainate-induced neurodegeneration

Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice

Glutamate-based anxiolytic ligands in clinical trials

Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740

LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress

Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition

Synthesis and characterization of 1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

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