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Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs

Molecular cell, 2021-01, Vol.81 (1), p.25-37.e4

2021

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K(V)7 potassium channels: a new therapeutic target in smooth muscle disorders

Drug discovery today, 2014-04, Vol.19 (4), p.413-424

2014

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The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

Epilepsia (Copenhagen), 2012-03, Vol.53 (3), p.412-424

2012

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Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries

Arteriosclerosis, thrombosis, and vascular biology, 2016-12, Vol.36 (12), p.2404

2016

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Atomic basis for therapeutic activation of neuronal potassium channels

Nature communications, 2015-09, Vol.6 (1), p.8116, Article 8116

2015

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Perivascular adipose tissue, potassium channels, and vascular dysfunction

Arteriosclerosis, thrombosis, and vascular biology, 2014-09, Vol.34 (9), p.1827

2014

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Novel treatment strategies for smooth muscle disorders: Targeting Kv7 potassium channels

Pharmacology & therapeutics (Oxford), 2016-09, Vol.165, p.14-25

2016

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Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly

Arteriosclerosis, thrombosis, and vascular biology, 2020-05, Vol.40 (5), p.1207

2020

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KV7 channelopathies

Pflügers Archiv, 2010-07, Vol.460 (2), p.277-288

2010

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Functional and behavioral signatures of Kv7 activator drug subtypes

Epilepsia (Copenhagen), 2020-08, Vol.61 (8), p.1678-1690

2020

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Oxidative modulation of voltage-gated potassium channels

Antioxidants & redox signaling, 2014-08, Vol.21 (6), p.933

2014

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Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity

Arteriosclerosis, thrombosis, and vascular biology, 2014-04, Vol.34 (4), p.887

2014

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Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons

Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (22), p.7869-7874

2008

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Reduced KCNQ4-Encoded Voltage-Dependent Potassium Channel Activity Underlies Impaired β-Adrenoceptor–Mediated Relaxation of Renal Arteries in Hypertension

Hypertension (Dallas, Tex. 1979), 2012-04, Vol.59 (4), p.877-884

2012

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Effect of M-current modulation on mammalian vestibular responses to transient head motion

Journal of neurophysiology, 2017-12, Vol.118 (6), p.2991-3006

2017

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Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide

Journal of hypertension, 2010-09, Vol.28 (9), p.1875-1882

2010

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Downregulation of Kv7.4 Channel Activity in Primary and Secondary Hypertension

Circulation (New York, N.Y.), 2011-08, Vol.124 (5), p.602-611

2011

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Functional expression of KCNQ (Kv7) channels in guinea pig bladder smooth muscle and their contribution to spontaneous activity

British journal of pharmacology, 2013-07, Vol.169 (6), p.1290-1304

2013

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KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus

Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (22), p.10232-10237

2010

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Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

Arteriosclerosis, thrombosis, and vascular biology, 2014-07, Vol.34 (7), p.1522

2014

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Structural Determinants of Kv7.5 Potassium Channels That Confer Changes in Phosphatidylinositol 4,5-Bisphosphate (PIP 2 ) Affinity and Signaling Sensitivities in Smooth Muscle Cells

Molecular pharmacology, 2020-03, Vol.97 (3), p.145-158

2020

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SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore

Biophysical journal, 2017-08, Vol.113 (3), p.613-626

2017

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Intracellular zinc protects Kv7 K + channels from Ca 2+ /calmodulin-mediated inhibition

The Journal of biological chemistry, 2023-02, Vol.299 (2), p.102819

2023

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Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673

Molecular pharmacology, 2014-09, Vol.86 (3), p.330-341

2014

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Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels

Journal of neurophysiology, 2016-11, Vol.116 (5), p.2114-2124

2016

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Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs

K(V)7 potassium channels: a new therapeutic target in smooth muscle disorders

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries

Atomic basis for therapeutic activation of neuronal potassium channels

Perivascular adipose tissue, potassium channels, and vascular dysfunction

Novel treatment strategies for smooth muscle disorders: Targeting Kv7 potassium channels

Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly

KV7 channelopathies

Functional and behavioral signatures of Kv7 activator drug subtypes

Oxidative modulation of voltage-gated potassium channels

Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity

Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons

Reduced KCNQ4-Encoded Voltage-Dependent Potassium Channel Activity Underlies Impaired β-Adrenoceptor–Mediated Relaxation of Renal Arteries in Hypertension

Effect of M-current modulation on mammalian vestibular responses to transient head motion

Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide

Downregulation of Kv7.4 Channel Activity in Primary and Secondary Hypertension

Functional expression of KCNQ (Kv7) channels in guinea pig bladder smooth muscle and their contribution to spontaneous activity

KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

Structural Determinants of Kv7.5 Potassium Channels That Confer Changes in Phosphatidylinositol 4,5-Bisphosphate (PIP 2 ) Affinity and Signaling Sensitivities in Smooth Muscle Cells

SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore

Intracellular zinc protects Kv7 K + channels from Ca 2+ /calmodulin-mediated inhibition

Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673

Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels

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