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BRD4 suppression alleviates cerebral ischemia-induced brain injury by blocking glial activation via the inhibition of inflammatory response and pyroptosis

Biochemical and biophysical research communications, 2019-11, Vol.519 (3), p.481-488

2019

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BET bromodomain inhibitors

Current opinion in chemical biology, 2022-06, Vol.68, p.102148-102148, Article 102148

2022

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BRD4 inhibition by JQ1 prevents high-fat diet-induced diabetic cardiomyopathy by activating PINK1/Parkin-mediated mitophagy in vivo

Journal of molecular and cellular cardiology, 2020-12, Vol.149, p.1-14

2020

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Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors

Cancer cell, 2018-03, Vol.33 (3), p.512-526.e8

2018

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JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS

Frontiers in immunology, 2021-02, Vol.12, p.609319-609319

2021

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Reprogramming Tumor Immune Microenvironment (TIME) and Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1

Nano letters, 2019-05, Vol.19 (5), p.2935-2944

2019

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Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma

Oncotarget, 2018-05, Vol.9 (33), p.23003-23017

2018

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Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

Cancer cell, 2018-01, Vol.33 (1), p.29-43.e7

2018

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Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation

Molecular cell, 2023-08, Vol.83 (16), p.2896-2910.e4

2023

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The Megacomplex protects ER-alpha from degradation by Fulvestrant in epithelial ovarian cancer

Cancer letters, 2024-07, p.217129, Article 217129

2024

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Study on the interaction of the bromodomain inhibitor JQ1 with human serum albumin by spectroscopic and molecular docking studies

Journal of molecular structure, 2023-02, Vol.1273, p.134374, Article 134374

2023

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The BET inhibitor JQ1 targets fat metabolism and counteracts obesity

Journal of advanced research, 2024-02

2024

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Targeting MYC Proteins for Tumor Therapy

Annual review of cancer biology, 2020-03, Vol.4 (1), p.61-75

2020

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Hitting two oncogenic machineries in cancer cells: cooperative effects of the multi-kinase inhibitor ponatinib and the BET bromodomain blockers JQ1 or dBET1 on human carcinoma cells

Oncotarget, 2018-05, Vol.9 (41), p.26491-26506

2018

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JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE

Brain research bulletin, 2022-10, Vol.189, p.174-183

2022

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Prevention of hepatic stellate cell activation using JQ1- and atorvastatin-loaded chitosan nanoparticles as a promising approach in therapy of liver fibrosis

European journal of pharmaceutics and biopharmaceutics, 2019-01, Vol.134, p.96-106

2019

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Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

Cell, 2018-03, Vol.173 (1), p.260-274.e25

2018

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Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)

Oncotarget, 2012-12, Vol.3 (12), p.1588-1599

2012

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Bromodomain and extraterminal domain-containing protein inhibition attenuates acute inflammation after spinal cord injury

Experimental neurology, 2018-11, Vol.309, p.181-192

2018

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YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4

Cell reports (Cambridge), 2022-06, Vol.39 (11), p.110970-110970, Article 110970

2022

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ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (9)

2021

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BET bromodomain inhibitor (JQ1) and tumor angiogenesis

Oncoscience, 2016, Vol.3 (11-12), p.316-317

2016

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JQ1 inhibits tumour growth in combination with cisplatin and suppresses JAK/STAT signalling pathway in ovarian cancer

European journal of cancer (1990), 2020-02, Vol.126, p.125-135

2020

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BET inhibitor JQ1 enhances anti-tumor immunity and synergizes with PD-1 blockade in CRC

Journal of Cancer, 2022-01, Vol.13 (7), p.2126-2137

2022

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BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer

Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (6), p.1

2022

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BRD4 suppression alleviates cerebral ischemia-induced brain injury by blocking glial activation via the inhibition of inflammatory response and pyroptosis

BET bromodomain inhibitors

BRD4 inhibition by JQ1 prevents high-fat diet-induced diabetic cardiomyopathy by activating PINK1/Parkin-mediated mitophagy in vivo

Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors

JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS

Reprogramming Tumor Immune Microenvironment (TIME) and Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1

Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation

The Megacomplex protects ER-alpha from degradation by Fulvestrant in epithelial ovarian cancer

Study on the interaction of the bromodomain inhibitor JQ1 with human serum albumin by spectroscopic and molecular docking studies

The BET inhibitor JQ1 targets fat metabolism and counteracts obesity

Targeting MYC Proteins for Tumor Therapy

Hitting two oncogenic machineries in cancer cells: cooperative effects of the multi-kinase inhibitor ponatinib and the BET bromodomain blockers JQ1 or dBET1 on human carcinoma cells

JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE

Prevention of hepatic stellate cell activation using JQ1- and atorvastatin-loaded chitosan nanoparticles as a promising approach in therapy of liver fibrosis

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)

Bromodomain and extraterminal domain-containing protein inhibition attenuates acute inflammation after spinal cord injury

YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4

ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts

BET bromodomain inhibitor (JQ1) and tumor angiogenesis

JQ1 inhibits tumour growth in combination with cisplatin and suppresses JAK/STAT signalling pathway in ovarian cancer

BET inhibitor JQ1 enhances anti-tumor immunity and synergizes with PD-1 blockade in CRC

BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer

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