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Roxadustat: First Global Approval

Drugs (New York, N.Y.), 2019-04, Vol.79 (5), p.563-572

Dhillon, Sohita

2019

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Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria

Angewandte Chemie International Edition, 2019-09, Vol.58 (37), p.13066-13079

International ed. in English, 2019

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Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents

Journal of medicinal chemistry, 2017-05, Vol.60 (9), p.3755-3775

2017

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Duvelisib, a novel oral dual inhibitor of PI3K-δ,γ, is clinically active in advanced hematologic malignancies

Blood, 2018-02, Vol.131 (8), p.877-887

2018

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DYNAMO: A Phase II Study of Duvelisib (IPI-145) in Patients With Refractory Indolent Non-Hodgkin Lymphoma

Journal of clinical oncology, 2019-04, Vol.37 (11), p.912-922

2019

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Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection

Hepatology (Baltimore, Md.), 2014-06, Vol.59 (6), p.2083-2091

2014

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Phase 3, Randomized, Double-Blind, Active-Comparator (Darbepoetin Alfa) Study of Oral Roxadustat in CKD Patients with Anemia on Hemodialysis in Japan

Journal of the American Society of Nephrology, 2020-07, Vol.31 (7), p.1628-1639

2020

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3-Arylisoquinolines as novel topoisomerase I inhibitors

Bioorganic & medicinal chemistry, 2011-01, Vol.19 (2), p.724-734

2011

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Activity of the PI3K-δ,γ inhibitor duvelisib in a phase 1 trial and preclinical models of T-cell lymphoma

Blood, 2018-02, Vol.131 (8), p.888-898

2018

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A marine microbiome antifungal targets urgent-threat drug-resistant fungi

Science (American Association for the Advancement of Science), 2020-11, Vol.370 (6519), p.974-978

2020

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Synthesis and antimicrobial evaluation of amino sugar-based naphthoquinones and isoquinoline-5,8-diones and their halogenated compounds

European journal of medicinal chemistry, 2018-08, Vol.156, p.1-12

2018

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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Nature chemical biology, 2015-06, Vol.11 (6), p.432-437

2015

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Molecular Mechanisms of Sanguinarine in Cancer Prevention and Treatment

Anti-cancer agents in medicinal chemistry, 2023-01, Vol.23 (7), p.765-778

2023

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Discovery and development of orexin receptor antagonists as therapeutics for insomnia

British journal of pharmacology, 2014-01, Vol.171 (2), p.283-293

2014

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Design, Synthesis, and Investigation of the Pharmacokinetics and Anticancer Activities of Indenoisoquinoline Derivatives That Stabilize the G‑Quadruplex in the MYC Promoter and Inhibit Topoisomerase I

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7006-7032

2024

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Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD

Clinical journal of the American Society of Nephrology, 2016-06, Vol.11 (6), p.982-991

2016

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Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-X L

Chemical communications (Cambridge, England), 2019-12, Vol.55 (98), p.14765-14768

2019

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A Structure–Activity Analysis of Biased Agonism at the Dopamine D2 Receptor

Journal of medicinal chemistry, 2013-11, Vol.56 (22), p.9199-9221

2013

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Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9703-9723

2017

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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5521-5542

2017

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Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors

Journal of medicinal chemistry, 2015-08, Vol.58 (16), p.6348-6358

2015

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The Stereoselective Total Synthesis of Axially Chiral Naphthylisoquinoline Alkaloids

Accounts of chemical research, 2022-09, Vol.55 (17), p.2370-2383

2022

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Lamellarin Sulfates from the Pacific Tunicate Didemnum ternerratum

Journal of natural products (Washington, D.C.), 2019-07, Vol.82 (7), p.2000-2008

2019

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Rhodium-Catalyzed Synthesis of 4-Bromo-1,2-dihydroisoquinolines: Access to Bromonium Ylides by the Intramolecular Reaction of a Benzyl Bromide and an α-Imino Carbene

Angewandte Chemie (International ed.), 2016-03, Vol.55 (14), p.4557-4561

2016

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Amberlite–IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: Antibacterial and antifungal evaluation of the products

European journal of medicinal chemistry, 2011-06, Vol.46 (6), p.2132-2140

2011

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Roxadustat: First Global Approval

Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria

Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents

Duvelisib, a novel oral dual inhibitor of PI3K-δ,γ, is clinically active in advanced hematologic malignancies

DYNAMO: A Phase II Study of Duvelisib (IPI-145) in Patients With Refractory Indolent Non-Hodgkin Lymphoma

Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection

Phase 3, Randomized, Double-Blind, Active-Comparator (Darbepoetin Alfa) Study of Oral Roxadustat in CKD Patients with Anemia on Hemodialysis in Japan

3-Arylisoquinolines as novel topoisomerase I inhibitors

Activity of the PI3K-δ,γ inhibitor duvelisib in a phase 1 trial and preclinical models of T-cell lymphoma

A marine microbiome antifungal targets urgent-threat drug-resistant fungi

Synthesis and antimicrobial evaluation of amino sugar-based naphthoquinones and isoquinoline-5,8-diones and their halogenated compounds

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Molecular Mechanisms of Sanguinarine in Cancer Prevention and Treatment

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

Design, Synthesis, and Investigation of the Pharmacokinetics and Anticancer Activities of Indenoisoquinoline Derivatives That Stabilize the G‑Quadruplex in the MYC Promoter and Inhibit Topoisomerase I

Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD

Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-X L

A Structure–Activity Analysis of Biased Agonism at the Dopamine D2 Receptor

Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)

Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors

The Stereoselective Total Synthesis of Axially Chiral Naphthylisoquinoline Alkaloids

Lamellarin Sulfates from the Pacific Tunicate Didemnum ternerratum

Rhodium-Catalyzed Synthesis of 4-Bromo-1,2-dihydroisoquinolines: Access to Bromonium Ylides by the Intramolecular Reaction of a Benzyl Bromide and an α-Imino Carbene

Amberlite–IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: Antibacterial and antifungal evaluation of the products

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