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Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

Nature biotechnology, 2014-04, Vol.32 (4), p.373-380

2014

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Simultaneous Voltammetric Determination of Acetaminophen and Isoniazid (Hepatotoxicity-Related Drugs) Utilizing Bismuth Oxide Nanorod Modified Screen-Printed Electrochemical Sensing Platforms

Analytical chemistry (Washington), 2017-02, Vol.89 (3), p.2170-2178

2017

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Metabolomics describes previously unknown toxicity mechanisms of isoniazid and rifampicin

Toxicology letters, 2020-04, Vol.322, p.104-110

2020

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New isoniazid derivatives with improved pharmaco-toxicological profile: Obtaining, characterization and biological evaluation

European journal of pharmaceutical sciences, 2019-09, Vol.137, p.104974, Article 104974

2019

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Involvement of dopamine signaling pathway in neurodevelopmental toxicity induced by isoniazid in zebrafish

Chemosphere (Oxford), 2021-02, Vol.265, p.129109, Article 129109

2021

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Specific receptor for hydrazine: mapping the in situ release of hydrazine in live cells and in an in vitro enzymatic assay

Chemical communications (Cambridge, England), 2016-01, Vol.52 (36), p.6166-6169

2016

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Pharmacokinetics, tissue distribution and relative bioavailability of isoniazid-solid lipid nanoparticles

International journal of pharmaceutics, 2013-01, Vol.441 (1-2), p.202-212

2013

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A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity

Clinical pharmacology and therapeutics, 2011-06, Vol.89 (6), p.911-914

2011

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Integration of metabolomics and proteomics analysis to explore the mechanism of neurotoxicity induced by receipt of isoniazid and rifampicin in mice

Neurotoxicology (Park Forest South), 2023-01, Vol.94, p.24-34

2023

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Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)?

Chemosphere (Oxford), 2020-01, Vol.238, p.124589, Article 124589

2020

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Effects of Solanum lycopersicum L. (tomato) against isoniazid and rifampicin induced hepatotoxicity in wistar albino rats

Brazilian journal of biology, 2024, Vol.84, p.e254552-8

2024

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A case series of three patients presenting with isoniazid induced toxicity and N-acetyl transferase 2 gene mutation: A management conundrum for programmatic therapy of tuberculosis in India

Indian journal of tuberculosis, 2020-07, Vol.67 (3), p.407-410

2020

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Antibacterial Activity of combinatorial treatments composed of transition-metal/antibiotics against Mycobacterium tuberculosis

Scientific reports, 2019-04, Vol.9 (1), p.5471, Article 5471

2019

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Gut microbiota affects sensitivity to immune-mediated isoniazid-induced liver injury

Biomedicine & pharmacotherapy, 2023-04, Vol.160, p.114400-114400, Article 114400

2023

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Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients

PloS one, 2017-10, Vol.12 (10), p.e0186200-e0186200

2017

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Nanoparticle Encapsulated Lipopeptide Conjugate of Antitubercular Drug Isoniazid: In Vitro Intracellular Activity and in Vivo Efficacy in a Guinea Pig Model of Tuberculosis

Bioconjugate chemistry, 2014-12, Vol.25 (12), p.2260-2268

2014

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Suppression of NRF2–ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells

Toxicology and applied pharmacology, 2016-02, Vol.292, p.1-7

2016

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Neurodevelopmental toxicity of pyrazinamide to larval zebrafish and the restoration after intoxication withdrawal

Journal of applied toxicology, 2022-07, Vol.42 (7), p.1276-1286

2022

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Rhus chinensis Mill. fruits alleviate liver injury induced by isoniazid and rifampicin through regulating oxidative stress, apoptosis, and bile acid transport

Journal of ethnopharmacology, 2023-06, Vol.310, p.116387-116387, Article 116387

2023

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Naringenin protects hepato-renal tissues against antituberculosis drugs induced toxic manifestations by modulating interleukin-6, insulin like growth factor-1, biochemical and ultra-structural integrity

Molecular biology reports, 2023-02, Vol.50 (2), p.1019-1031

2023

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Hepatotoxicity mechanisms of isoniazid: A mini-review

Journal of applied toxicology, 2015-12, Vol.35 (12), p.1427-1432

2015

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Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity

Experimental and Molecular Medicine, 2024, 56(0), , pp.570-582

2024

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Hepatocyte growth factor protects against isoniazid/rifampicin-induced oxidative liver damage

Toxicological sciences, 2013-09, Vol.135 (1), p.26-36

2013

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The Combination of Anti-CTLA‑4 and PD1–/– Mice Unmasks the Potential of Isoniazid and Nevirapine To Cause Liver Injury

Chemical research in toxicology, 2015-12, Vol.28 (12), p.2287-2291

2015

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Isoniazid induces apoptosis: Role of oxidative stress and inhibition of nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)

Life sciences (1973), 2018-04, Vol.199, p.23-33

2018

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Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

Simultaneous Voltammetric Determination of Acetaminophen and Isoniazid (Hepatotoxicity-Related Drugs) Utilizing Bismuth Oxide Nanorod Modified Screen-Printed Electrochemical Sensing Platforms

Metabolomics describes previously unknown toxicity mechanisms of isoniazid and rifampicin

New isoniazid derivatives with improved pharmaco-toxicological profile: Obtaining, characterization and biological evaluation

Involvement of dopamine signaling pathway in neurodevelopmental toxicity induced by isoniazid in zebrafish

Specific receptor for hydrazine: mapping the in situ release of hydrazine in live cells and in an in vitro enzymatic assay

Pharmacokinetics, tissue distribution and relative bioavailability of isoniazid-solid lipid nanoparticles

A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity

Integration of metabolomics and proteomics analysis to explore the mechanism of neurotoxicity induced by receipt of isoniazid and rifampicin in mice

Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)?

Effects of Solanum lycopersicum L. (tomato) against isoniazid and rifampicin induced hepatotoxicity in wistar albino rats

A case series of three patients presenting with isoniazid induced toxicity and N-acetyl transferase 2 gene mutation: A management conundrum for programmatic therapy of tuberculosis in India

Antibacterial Activity of combinatorial treatments composed of transition-metal/antibiotics against Mycobacterium tuberculosis

Gut microbiota affects sensitivity to immune-mediated isoniazid-induced liver injury

Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients

Nanoparticle Encapsulated Lipopeptide Conjugate of Antitubercular Drug Isoniazid: In Vitro Intracellular Activity and in Vivo Efficacy in a Guinea Pig Model of Tuberculosis

Suppression of NRF2–ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells

Neurodevelopmental toxicity of pyrazinamide to larval zebrafish and the restoration after intoxication withdrawal

Rhus chinensis Mill. fruits alleviate liver injury induced by isoniazid and rifampicin through regulating oxidative stress, apoptosis, and bile acid transport

Naringenin protects hepato-renal tissues against antituberculosis drugs induced toxic manifestations by modulating interleukin-6, insulin like growth factor-1, biochemical and ultra-structural integrity

Hepatotoxicity mechanisms of isoniazid: A mini-review

Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity

Hepatocyte growth factor protects against isoniazid/rifampicin-induced oxidative liver damage

The Combination of Anti-CTLA‑4 and PD1–/– Mice Unmasks the Potential of Isoniazid and Nevirapine To Cause Liver Injury

Isoniazid induces apoptosis: Role of oxidative stress and inhibition of nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)

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