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Trial of Deferiprone in Parkinson’s Disease

The New England journal of medicine, 2022-12, Vol.387 (22), p.2045-2055

2022

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Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice

Journal of cerebral blood flow and metabolism, 2017-09, Vol.37 (9), p.3110-3123

2017

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A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in β-thalassemia major (CORDELIA)

Blood, 2014-03, Vol.123 (10), p.1447-1454

2014

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Compliance and clinical benefit of deferasirox granule and dispersible tablet formulation in pediatric patients with transfusional iron overload: in a randomized, open-label, multicenter, phase II study

Haematologica (Roma), 2024-05, Vol.109 (5), p.1413

2024

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Iron-Chelating Therapy for Transfusional Iron Overload

The New England journal of medicine, 2011-01, Vol.364 (2), p.146-156

Brittenham, Gary M

2011

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The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial

Journal of antimicrobial chemotherapy, 2012-03, Vol.67 (3), p.715-722

2012

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Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

Free radical biology & medicine, 2013-09, Vol.62, p.52-64

2013

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Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up

Blood, 2011-07, Vol.118 (4), p.884-893

2011

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CN128: A New Orally Active Hydroxypyridinone Iron Chelator

Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.4215-4226

2020

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Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload

Blood, 2015-06, Vol.125 (25), p.3868-3877

2015

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Deferasirox for managing iron overload in people with thalassaemia

Cochrane database of systematic reviews, 2017-08, Vol.8 (8), p.CD007476

2017

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Real‐world evidence: Long‐term safety of deferiprone in a large cohort of patients with sickle cell disease enrolled in a registry for up to 10 years

American journal of hematology, 2024-06, Vol.99 (6), p.1031-1039

2024

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Selective iron chelation in Friedreich ataxia: biologic and clinical implications

Blood, 2007-07, Vol.110 (1), p.401-408

2007

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A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors

Investigational new drugs, 2019-08, Vol.37 (4), p.684-692

2019

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Efficacy and safety of a novel combination of two oral chelators deferasirox/deferiprone over deferoxamine/deferiprone in severely iron overloaded young beta thalassemia major patients

European journal of haematology, 2015-11, Vol.95 (5), p.411-420

2015

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Deferiprone ameliorates memory impairment in Scopolamine-treated rats: The impact of its iron-chelating effect on β-amyloid disposition

Behavioural brain research, 2020-01, Vol.378, p.112314, Article 112314

2020

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Effects of dietary polyphenol supplementation on iron status and erythropoiesis: a systematic review and meta-analysis of randomized controlled trials

The American journal of clinical nutrition, 2021-08, Vol.114 (2), p.780-793

2021

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Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

Neurobiology of aging, 2013-02, Vol.34 (2), p.562-575

2013

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The Oral Ferroportin Inhibitor VIT-2763 Improves Erythropoiesis without Interfering with Iron Chelation Therapy in a Mouse Model of β-Thalassemia

International journal of molecular sciences, 2021-01, Vol.22 (2), p.873

2021

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SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia

British journal of haematology, 2021-07, Vol.194 (1), p.200-210

2021

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Iron Chelation Nanoparticles with Delayed Saturation as an Effective Therapy for Parkinson Disease

Biomacromolecules, 2017-02, Vol.18 (2), p.461-474

2017

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Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo

British journal of pharmacology, 2013-03, Vol.168 (6), p.1316-1328

2013

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Trial of Deferiprone in Parkinson’s Disease

Targeting chelatable iron as a therapeutic modality in Parkinson's disease

Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice

Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis?

A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in β-thalassemia major (CORDELIA)

Compliance and clinical benefit of deferasirox granule and dispersible tablet formulation in pediatric patients with transfusional iron overload: in a randomized, open-label, multicenter, phase II study

Iron-Chelating Therapy for Transfusional Iron Overload

The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up

CN128: A New Orally Active Hydroxypyridinone Iron Chelator

Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload

Deferasirox for managing iron overload in people with thalassaemia

A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia

Real‐world evidence: Long‐term safety of deferiprone in a large cohort of patients with sickle cell disease enrolled in a registry for up to 10 years

Selective iron chelation in Friedreich ataxia: biologic and clinical implications

A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors

Efficacy and safety of a novel combination of two oral chelators deferasirox/deferiprone over deferoxamine/deferiprone in severely iron overloaded young beta thalassemia major patients

Deferiprone ameliorates memory impairment in Scopolamine-treated rats: The impact of its iron-chelating effect on β-amyloid disposition

Effects of dietary polyphenol supplementation on iron status and erythropoiesis: a systematic review and meta-analysis of randomized controlled trials

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

The Oral Ferroportin Inhibitor VIT-2763 Improves Erythropoiesis without Interfering with Iron Chelation Therapy in a Mouse Model of β-Thalassemia

SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia

Iron Chelation Nanoparticles with Delayed Saturation as an Effective Therapy for Parkinson Disease

Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo

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