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TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures

The Journal of cell biology, 2014-01, Vol.204 (2), p.231-245

2014

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Oncogenically active MYD88 mutations in human lymphoma

Nature (London), 2011-02, Vol.470 (7332), p.115-119

2011

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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

Cell, 2017-01, Vol.168 (1-2), p.59-72.e13

2017

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The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

Biochemical journal, 2017-06, Vol.474 (12), p.2027-2038

2017

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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

Nature (London), 2010-06, Vol.465 (7300), p.885-890

2010

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MicroRNA-146a and MicroRNA-146b Regulate Human Dendritic Cell Apoptosis and Cytokine Production by Targeting TRAF6 and IRAK1 Proteins

The Journal of biological chemistry, 2015-01, Vol.290 (5), p.2831-2841

2015

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Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (38), p.15247-15252

2013

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IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes

Nature immunology, 2020-10, Vol.21 (10), p.1219-1231

2020

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miR-142a-3p Enhances FlaA N/C Protection Against Radiation-Mediated Intestinal Injury by Modulating the IRAK1/NF-κB Signaling Pathway

International journal of radiation oncology, biology, physics, 2022-04, Vol.112 (5), p.1256-1268

2022

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Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome

The Journal of immunology (1950), 2013-10, Vol.191 (8), p.3995-3999

2013

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IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly

Molecular cell, 2014-09, Vol.55 (6), p.891-903

2014

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Interleukin-1 β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis

Journal of the American Society of Nephrology, 2018-06, Vol.29 (6), p.1690-1705

2018

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IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies

Current opinion in hematology, 2022-01, Vol.29 (1), p.8-19

2022

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Paternal Control of Embryonic Patterning in Arabidopsis thaliana

Science (American Association for the Advancement of Science), 2009-03, Vol.323 (5920), p.1485-1488

2009

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The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis

Nature communications, 2016-11, Vol.7 (1), p.13436-13436, Article 13436

2016

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IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel

Nature communications, 2015-10, Vol.6 (1), p.8746-8746, Article 8746

2015

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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5521-5542

2017

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Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

The Journal of experimental medicine, 2007-10, Vol.204 (10), p.2407-2422

2007

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In vivo ablation of NF-κB cascade effectors alleviates disease burden in myeloproliferative neoplasms

Blood, 2024-06, Vol.143 (23), p.2414

2024

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Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

Free radical biology & medicine, 2016-04, Vol.93, p.190-203

2016

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Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy

The Journal of experimental medicine, 2015-12, Vol.212 (13), p.2189-2201

2015

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LXA4 protected mice from renal ischemia/reperfusion injury by promoting IRG1/Nrf2 and IRAK-M-TRAF6 signal pathways

Clinical immunology (Orlando, Fla.), 2024-04, Vol.261, p.110167-110167, Article 110167

2024

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Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation

Structure (London), 2021-03, Vol.29 (3), p.238-251.e4

2021

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Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.96-110

2015

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IL-1 receptor-associated kinase family proteins: An overview of their role in liver disease

European journal of pharmacology, 2024-09, Vol.978, p.176773, Article 176773

2024

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TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures

Oncogenically active MYD88 mutations in human lymphoma

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

MicroRNA-146a and MicroRNA-146b Regulate Human Dendritic Cell Apoptosis and Cytokine Production by Targeting TRAF6 and IRAK1 Proteins

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes

miR-142a-3p Enhances FlaA N/C Protection Against Radiation-Mediated Intestinal Injury by Modulating the IRAK1/NF-κB Signaling Pathway

Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome

IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly

Interleukin-1 β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis

IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies

Paternal Control of Embryonic Patterning in Arabidopsis thaliana

The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel

Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

In vivo ablation of NF-κB cascade effectors alleviates disease burden in myeloproliferative neoplasms

Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy

LXA4 protected mice from renal ischemia/reperfusion injury by promoting IRG1/Nrf2 and IRAK-M-TRAF6 signal pathways

Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation

Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders

IL-1 receptor-associated kinase family proteins: An overview of their role in liver disease

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