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Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Nature (London), 2014-07, Vol.511 (7507), p.94-98

2014

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Insulin-Degrading Enzyme in the Fight against Alzheimer’s Disease

Trends in pharmacological sciences (Regular ed.), 2018-01, Vol.39 (1), p.49-58

2018

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Inhibition of Insulin Degrading Enzyme to Control Diabetes Mellitus and its Applications on some Other Chronic Disease: a Critical Review

Pharmaceutical research, 2022-04, Vol.39 (4), p.611-629

2022

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Interleukin-6 increases the expression and activity of insulin-degrading enzyme

Scientific reports, 2017-04, Vol.7 (1), p.46750-46750, Article 46750

2017

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Degradation of Alzheimer’s Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme

Journal of molecular biology, 2021-06, Vol.433 (13), p.166993-166993, Article 166993

2021

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Insulin-Degrading Enzyme: Paradoxes and Possibilities

Cells (Basel, Switzerland), 2021-09, Vol.10 (9), p.2445

Leissring, Malcolm A

2021

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Toward Allosterically Increased Catalytic Activity of Insulin-Degrading Enzyme against Amyloid Peptides

Biochemistry (Easton), 2017-01, Vol.56 (1), p.228-239

2017

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The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S

Cellular and molecular life sciences : CMLS, 2018-09, Vol.75 (18), p.3441-3456

2018

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Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications

Journal of Alzheimer's disease, 2015-01, Vol.48 (4), p.891-917

2015

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Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity

American journal of physiology: endocrinology and metabolism, 2019-11, Vol.317 (5), p.E805-E819

2019

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Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome

Scientific reports, 2022-11, Vol.12 (1), p.19808-19808, Article 19808

2022

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Insulin-Degrading Enzyme Regulates the Levels of Insulin, Amyloid β-Protein, and the β-Amyloid Precursor Protein Intracellular Domain in vivo

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (7), p.4162-4167

2003

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Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo

The Journal of biological chemistry, 2015-08, Vol.290 (33), p.20044-20059

2015

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Correlations between insulin-degrading enzyme and metabolic markers in patients diagnosed with type 2 diabetes, Alzheimer’s disease, and healthy controls: a comparative study

Endocrine, 2024-05, Vol.84 (2), p.450-458

2024

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Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

Neuron (Cambridge, Mass.), 2003-12, Vol.40 (6), p.1087-1093

2003

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Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

Scientific reports, 2015-07, Vol.5 (1), p.12531-12531, Article 12531

2015

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Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media

Journal of biotechnology, 2020-08, Vol.320, p.44-49

2020

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Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues

American journal of physiology: endocrinology and metabolism, 2019-01, Vol.316 (1), p.E106-E120

2019

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Induction of ICAM1 in Brain Vessels is Implicated in an Early AD Pathogenesis by Modulating Neprilysin

Neuromolecular medicine, 2023-06, Vol.25 (2), p.193-204

2023

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Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes

Proceedings of the National Academy of Sciences - PNAS, 2017-04, Vol.114 (14), p.E2826-E2835

2017

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Multiple functions of insulin-degrading enzyme: a metabolic crosslight?

Critical reviews in biochemistry and molecular biology, 2017-09, Vol.52 (5), p.554-582

2017

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Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

Metabolism, clinical and experimental, 2018-11, Vol.88, p.1-11

2018

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Optimization of Peptide Hydroxamate Inhibitors of Insulin-Degrading Enzyme Reveals Marked Substrate-Selectivity

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2246-2255

2013

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Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (34), p.13827-13832

2013

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Loss of renal SNX5 results in impaired IDE activity and insulin resistance in mice

Diabetologia, 2018-03, Vol.61 (3), p.727-737

2018

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Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Insulin-Degrading Enzyme in the Fight against Alzheimer’s Disease

Inhibition of Insulin Degrading Enzyme to Control Diabetes Mellitus and its Applications on some Other Chronic Disease: a Critical Review

Interleukin-6 increases the expression and activity of insulin-degrading enzyme

Degradation of Alzheimer’s Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme

Insulin-Degrading Enzyme: Paradoxes and Possibilities

Toward Allosterically Increased Catalytic Activity of Insulin-Degrading Enzyme against Amyloid Peptides

The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S

Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications

Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity

Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome

Insulin-Degrading Enzyme Regulates the Levels of Insulin, Amyloid β-Protein, and the β-Amyloid Precursor Protein Intracellular Domain in vivo

Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo

Correlations between insulin-degrading enzyme and metabolic markers in patients diagnosed with type 2 diabetes, Alzheimer’s disease, and healthy controls: a comparative study

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media

Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues

Induction of ICAM1 in Brain Vessels is Implicated in an Early AD Pathogenesis by Modulating Neprilysin

Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes

Multiple functions of insulin-degrading enzyme: a metabolic crosslight?

Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

Optimization of Peptide Hydroxamate Inhibitors of Insulin-Degrading Enzyme Reveals Marked Substrate-Selectivity

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

Loss of renal SNX5 results in impaired IDE activity and insulin resistance in mice

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