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Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

Nature communications, 2015-04, Vol.6 (1), p.6780-6780, Article 6780

2015

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USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination

Biochemical and biophysical research communications, 2017-03, Vol.484 (3), p.522-528

2017

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Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis

The Journal of biological chemistry, 2011-06, Vol.286 (23), p.20812-20822

2011

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Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs

Biochemical and biophysical research communications, 2012-06, Vol.423 (1), p.122-127

2012

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Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases

Biochemical and biophysical research communications, 2011-01, Vol.404 (3), p.767-773

2011

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Phosphatidylinositol 3-Kinase (PI3K) Activity Bound to Insulin-like Growth Factor-I (IGF-I) Receptor, which Is Continuously Sustained by IGF-I Stimulation, Is Required for IGF-I-induced Cell Proliferation

The Journal of biological chemistry, 2012-08, Vol.287 (35), p.29713-29721

2012

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Par14 Protein Associates with Insulin Receptor Substrate 1 (IRS-1), Thereby Enhancing Insulin-induced IRS-1 Phosphorylation and Metabolic Actions

The Journal of biological chemistry, 2013-07, Vol.288 (28), p.20692-20701

2013

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Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes

FEBS letters, 2013-08, Vol.587 (15), p.2319-2324

2013

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PGC1A regulates the IRS1: IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (10), p.4285-4290

2019

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Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease: A Secondary Analysis of the Exenatide-PD Trial

JAMA neurology, 2019-04, Vol.76 (4), p.420

2019

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Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

Diabetologia, 2012-10, Vol.55 (10), p.2565-2582

2012

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Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle

Diabetes (New York, N.Y.), 2017-07, Vol.66 (7), p.1807-1818

2017

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Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway

Cell metabolism, 2017-04, Vol.25 (4), p.797-810

2017

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High uric acid directly inhibits insulin signalling and induces insulin resistance

Biochemical and biophysical research communications, 2014-05, Vol.447 (4), p.707-714

2014

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Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice

Endocrinology (Philadelphia), 2023-03, Vol.164 (3), p.1

2023

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Phosphorylation of IRS proteins, insulin action, and insulin resistance

American journal of physiology: endocrinology and metabolism, 2009-04, Vol.296 (4), p.E581-E591

2009

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Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Nature medicine, 2012-07, Vol.18 (7), p.1095-1101

2012

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Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin

Nature communications, 2021-09, Vol.12 (1), p.5296-5296, Article 5296

2021

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MicroRNA 7 Impairs Insulin Signaling and Regulates Aβ Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway

Molecular and cellular biology, 2019-11, Vol.39 (22)

2019

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The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction

Proceedings of the National Academy of Sciences - PNAS, 2024-04, Vol.121 (17), p.e2401716121

2024

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Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer

Nature communications, 2021-05, Vol.12 (1), p.2699-2699, Article 2699

2021

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Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Neurobiology of aging, 2010-02, Vol.31 (2), p.224-243

2010

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Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer’s Disease-like Neurotoxicity

Scientific reports, 2017-08, Vol.7 (1), p.7497-12, Article 7497

2017

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HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells

Molecular and cellular endocrinology, 2011-09, Vol.344 (1), p.81-89

2011

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TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

Nature communications, 2015-08, Vol.6 (1), p.7951-7951, Article 7951

2015

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Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination

Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs

Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases

Phosphatidylinositol 3-Kinase (PI3K) Activity Bound to Insulin-like Growth Factor-I (IGF-I) Receptor, which Is Continuously Sustained by IGF-I Stimulation, Is Required for IGF-I-induced Cell Proliferation

Par14 Protein Associates with Insulin Receptor Substrate 1 (IRS-1), Thereby Enhancing Insulin-induced IRS-1 Phosphorylation and Metabolic Actions

Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes

PGC1A regulates the IRS1: IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin

Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease: A Secondary Analysis of the Exenatide-PD Trial

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle

Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway

High uric acid directly inhibits insulin signalling and induces insulin resistance

Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice

Phosphorylation of IRS proteins, insulin action, and insulin resistance

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin

MicroRNA 7 Impairs Insulin Signaling and Regulates Aβ Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway

The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction

Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer’s Disease-like Neurotoxicity

HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells

TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

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