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The Activation Mechanism of the Insulin Receptor: A Structural Perspective

Annual review of biochemistry, 2023-06, Vol.92 (1), p.247-272

2023

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Rapid-Acting and Human Insulins: Hexamer Dissociation Kinetics upon Dilution of the Pharmaceutical Formulation

Pharmaceutical research, 2017-11, Vol.34 (11), p.2270-2286

2017

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Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

The Journal of biological chemistry, 2019-11, Vol.294 (46), p.17371-17382

2019

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Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

The Journal of cell biology, 2020-01, Vol.219 (1), p.1

2020

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Synergistic activation of the insulin receptor via two distinct sites

Nature structural & molecular biology, 2022-04, Vol.29 (4), p.357-368

2022

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Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex

eLife, 2019-08, Vol.8

2019

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How insulin engages its primary binding site on the insulin receptor

Nature (London), 2013-01, Vol.493 (7431), p.241-245

2013

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Identification of recombinant human insulin and biosynthetic insulin analogues by multiplexed targeted unlabeled mass spectrometry of proteotypic tryptic peptides

Journal of pharmaceutical and biomedical analysis, 2019-08, Vol.172, p.357-363

2019

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A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

Nature structural & molecular biology, 2020-07, Vol.27 (7), p.615-624

2020

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Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin

Chemistry : a European journal, 2019-06, Vol.25 (36), p.8513-8521

2019

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A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Nature structural & molecular biology, 2016-10, Vol.23 (10), p.916-920

2016

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Single-site glycine-specific labeling of proteins

Nature communications, 2019-06, Vol.10 (1), p.2539-2539, Article 2539

2019

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An overview of the insulin signaling pathway in model organisms Drosophila melanogaster and Caenorhabditis elegans

Peptides (New York, N.Y. : 1980), 2021-11, Vol.145, p.170640-170640, Article 170640

2021

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A λ‑Dynamics Investigation of Insulin Wakayama and Other A3 Variant Binding Affinities to the Insulin Receptor

Journal of chemical information and modeling, 2024-07, Vol.64 (14), p.5657-5670

2024

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Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

BioEssays, 2009-04, Vol.31 (4), p.422-434

2009

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Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation

Biochemistry (Easton), 2018-04, Vol.57 (16), p.2373-2382

2018

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Molecular investigation of glycated insulin-induced insulin resistance via insulin signaling and AGE-RAGE axis

Biochimica et biophysica acta. Molecular basis of disease, 2021-02, Vol.1867 (2), p.166029-166029, Article 166029

2021

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Formulary Considerations for Insulins Approved Through the 505(b)(2) "Follow-on" Pathway

The Annals of pharmacotherapy, 2019-02, Vol.53 (2), p.204-210

2019

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Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

eLife, 2019-02, Vol.8

2019

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Effects of Phenol and meta-Cresol Depletion on Insulin Analog Stability at Physiological Temperature

Journal of pharmaceutical sciences, 2014-08, Vol.103 (8), p.2255-2267

2014

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Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor

Nature structural & molecular biology, 2023-05, Vol.30 (5), p.661-669

2023

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Combinatorial Libraries of Bipodal Binders of the Insulin Receptor

ChemMedChem, 2024-06, Vol.19 (11), p.e202400145-n/a

2024

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Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY

The Journal of biological chemistry, 2016-12, Vol.291 (53), p.27023-27041

2016

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A thing of beauty: Structure and function of insulin's “aromatic triplet”

Diabetes, obesity & metabolism, 2018-09, Vol.20 (S2), p.51-63

2018

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Insulin signaling to hepatic lipid metabolism in health and disease

Critical reviews in biochemistry and molecular biology, 2011-06, Vol.46 (3), p.200-215

2011

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The Activation Mechanism of the Insulin Receptor: A Structural Perspective

Rapid-Acting and Human Insulins: Hexamer Dissociation Kinetics upon Dilution of the Pharmaceutical Formulation

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

Synergistic activation of the insulin receptor via two distinct sites

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex

How insulin engages its primary binding site on the insulin receptor

Identification of recombinant human insulin and biosynthetic insulin analogues by multiplexed targeted unlabeled mass spectrometry of proteotypic tryptic peptides

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Single-site glycine-specific labeling of proteins

An overview of the insulin signaling pathway in model organisms Drosophila melanogaster and Caenorhabditis elegans

A λ‑Dynamics Investigation of Insulin Wakayama and Other A3 Variant Binding Affinities to the Insulin Receptor

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation

Molecular investigation of glycated insulin-induced insulin resistance via insulin signaling and AGE-RAGE axis

Formulary Considerations for Insulins Approved Through the 505(b)(2) "Follow-on" Pathway

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

Effects of Phenol and meta-Cresol Depletion on Insulin Analog Stability at Physiological Temperature

Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor

Combinatorial Libraries of Bipodal Binders of the Insulin Receptor

Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY

A thing of beauty: Structure and function of insulin's “aromatic triplet”

Insulin signaling to hepatic lipid metabolism in health and disease

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