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Mechanism and Regulation of NLRP3 Inflammasome Activation

Trends in biochemical sciences (Amsterdam. Regular ed.), 2016-12, Vol.41 (12), p.1012-1021

2016

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Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

Journal of the American Heart Association, 2017-09, Vol.6 (9), p.n/a

2017

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Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages

Arteriosclerosis, thrombosis, and vascular biology, 2018-04, Vol.38 (4), p.744-756

2018

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Novel role of PKR in inflammasome activation and HMGB1 release

Nature (London), 2012-08, Vol.488 (7413), p.670-674

2012

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TREM‐1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway

The FEBS journal, 2023-03, Vol.290 (6), p.1549-1562

2023

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Supraphysiological Levels of Testosterone Induce Vascular Dysfunction via Activation of the NLRP3 Inflammasome

Frontiers in immunology, 2020-07, Vol.11, p.1647

2020

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NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features

Frontiers in immunology, 2020-08, Vol.11, p.1828-1828

2020

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Therapeutic Potential of Pharmacological Targeting NLRP3 Inflammasome Complex in Cancer

Frontiers in immunology, 2021-02, Vol.11, p.607881-607881

2021

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The Nlrp3 Inflammasome Orchestrates Mobilization of Bone Marrow-Residing Stem Cells into Peripheral Blood

Stem cell reviews, 2019-06, Vol.15 (3), p.391-403

2019

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Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells

PloS one, 2013-08, Vol.8 (8), p.e72344-e72344

2013

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Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions

Chemical research in toxicology, 2021-08, Vol.34 (8), p.1860-1865

2021

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Chemical mitochondrial uncouplers share common inhibitory effect on NLRP3 inflammasome activation through inhibiting NFκB nuclear translocation

Toxicology and applied pharmacology, 2021-03, Vol.414, p.115426, Article 115426

2021

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Callintegers A and B, Unusual Tricyclo[4.4.0.09,10]tetradecane Clerodane Diterpenoids from Callicarpa integerrima with Inhibitory Effects on NLRP3 Inflammasome Activation

Journal of natural products (Washington, D.C.), 2022-11, Vol.85 (11), p.2675-2681

2022

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Sintered indium-tin oxide particles induce pro-inflammatory responses in vitro, in part through inflammasome activation

PloS one, 2015-04, Vol.10 (4), p.e0124368-e0124368

2015

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WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3

Cancer science, 2017-03, Vol.108 (3), p.520-527

2017

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Agmatine Reverses Sub‐chronic Stress induced Nod‐like Receptor Protein 3 (NLRP3) Activation and Cytokine Response in Rats

Basic & clinical pharmacology & toxicology, 2016-10, Vol.119 (4), p.367-375

2016

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Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome

Inflammation, 2019-06, Vol.42 (3), p.904-914

2019

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Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

The Journal of biological chemistry, 2016-01, Vol.291 (3), p.1123-1136

2016

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P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases

European journal of pharmacology, 2021-09, Vol.906, p.174235-174235, Article 174235

2021

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The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

The Journal of biological chemistry, 2017-07, Vol.292 (29), p.12077-12087

2017

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The P2X7 Receptor in Infection and Inflammation

Immunity (Cambridge, Mass.), 2017-07, Vol.47 (1), p.15-31

2017

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Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

The FEBS journal, 2021-05, Vol.288 (10), p.3186-3196

2021

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Human STING is a proton channel

Science (American Association for the Advancement of Science), 2023-08, Vol.381 (6657), p.508-514

2023

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Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

The Journal of biological chemistry, 2017-07, Vol.292 (29), p.12153-12164

2017

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Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice

Gastroenterology (New York, N.Y. 1943), 2018-04, Vol.154 (5), p.1449-1464.e20

2018

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Mechanism and Regulation of NLRP3 Inflammasome Activation

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages

Novel role of PKR in inflammasome activation and HMGB1 release

TREM‐1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway

Supraphysiological Levels of Testosterone Induce Vascular Dysfunction via Activation of the NLRP3 Inflammasome

NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features

Therapeutic Potential of Pharmacological Targeting NLRP3 Inflammasome Complex in Cancer

The Nlrp3 Inflammasome Orchestrates Mobilization of Bone Marrow-Residing Stem Cells into Peripheral Blood

Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells

Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions

Chemical mitochondrial uncouplers share common inhibitory effect on NLRP3 inflammasome activation through inhibiting NFκB nuclear translocation

Callintegers A and B, Unusual Tricyclo[4.4.0.09,10]tetradecane Clerodane Diterpenoids from Callicarpa integerrima with Inhibitory Effects on NLRP3 Inflammasome Activation

Sintered indium-tin oxide particles induce pro-inflammatory responses in vitro, in part through inflammasome activation

WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3

Agmatine Reverses Sub‐chronic Stress induced Nod‐like Receptor Protein 3 (NLRP3) Activation and Cytokine Response in Rats

Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases

The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

The P2X7 Receptor in Infection and Inflammation

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

Human STING is a proton channel

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice

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