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Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

Nature communications, 2019-03, Vol.10 (1), p.1269-9, Article 1269

2019

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Truncation of the constant domain drives amyloid formation by immunoglobulin light chains

The Journal of biological chemistry, 2024-04, Vol.300 (4), p.107174-107174, Article 107174

2024

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Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis

Nature communications, 2021-02, Vol.12 (1), p.875-875, Article 875

2021

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Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis

The Journal of biological chemistry, 2020-12, Vol.295 (49), p.16572-16584

2020

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Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity

Scientific reports, 2017-12, Vol.7 (1), p.16809-11, Article 16809

2017

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Cyclization of Single-Chain Fv Antibodies Markedly Suppressed Their Characteristic Aggregation Mediated by Inter-Chain VH-VL Interactions

Molecules (Basel, Switzerland), 2019-07, Vol.24 (14), p.2620

2019

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New developments in diagnosis, risk assessment and management in systemic amyloidosis

Blood reviews, 2020-03, Vol.40, p.100636-100636, Article 100636

2020

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Computational evidences of a misfolding event in an aggregation‐prone light chain preceding the formation of the non‐native pathogenic dimer

Proteins, structure, function, and bioinformatics, 2024-07, Vol.92 (7), p.797-807

2024

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Seeded fibrils of the germline variant of human λ-III immunoglobulin light chain FOR005 have a similar core as patient fibrils with reduced stability

The Journal of biological chemistry, 2020-12, Vol.295 (52), p.18474-18484

2020

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Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis

The Journal of biological chemistry, 2018-12, Vol.293 (51), p.19659-19671

2018

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Methods to study the structure of misfolded protein states in systemic amyloidosis

Biochemical Society transactions, 2021-04, Vol.49 (2), p.977

2021

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In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study

Scientific reports, 2016-07, Vol.6 (1), p.29096-29096, Article 29096

2016

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Intra‐ and extracellular crystal deposition in a case of amyloid light chain amyloidosis

British journal of haematology, 2022-02, Vol.196 (3), p.463-463

2022

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Light chain amyloidosis: Where are the light chains from and how they play their pathogenic role?

Blood reviews, 2017-07, Vol.31 (4), p.261-270

2017

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Cu(II) Binding Increases the Soluble Toxicity of Amyloidogenic Light Chains

International journal of molecular sciences, 2022-01, Vol.23 (2), p.950

2022

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A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis

Communications biology, 2023-02, Vol.6 (1), p.209-209, Article 209

2023

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Outcomes of patients with AL amyloidosis and low serum free light chain levels at diagnosis

Amyloid, 2018-07, Vol.25 (3), p.156-159

2018

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Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library

mAbs, 2014-03, Vol.6 (2), p.446-459

2014

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Free light chains: Eclectic multipurpose biomarker

Journal of immunological methods, 2017-12, Vol.451, p.11-19

2017

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Control of Early B Cell Development by the RNA N 6 -Methyladenosine Methylation

Cell reports (Cambridge), 2020-06, Vol.31 (13), p.107819

2020

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Distinct β‑Sheet Structure in Protein Aggregates Determined by ATR–FTIR Spectroscopy

Biochemistry (Easton), 2013-08, Vol.52 (31), p.5176-5183

2013

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A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis

Blood, 2014-10, Vol.124 (15), p.2325-2332

2014

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Immunoglobulin light chain amyloidosis: 2022 update on diagnosis, prognosis, and treatment

American journal of hematology, 2022-06, Vol.97 (6), p.818-829

Gertz, Morie A.

2022

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Lenalidomide and dexamethasone in relapsed/refractory immunoglobulin light chain (AL) amyloidosis: results from a large cohort of patients with long follow‐up

British journal of haematology, 2021-10, Vol.195 (2), p.230-243

2021

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Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation

The FEBS journal, 2022-01, Vol.289 (2), p.494-506

2022

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