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A Highly Selective Hydantoin Inhibitor of Aggrecanase‑1 and Aggrecanase‑2 with a Low Projected Human Dose

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5933-5939

2017

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Determination of methyl isopropyl hydantoin from rat erythrocytes by gas-chromatography mass-spectrometry to determine methyl isocyanate dose following inhalation exposure

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018-09, Vol.1093-1094, p.119-127

2018

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Analytical determination of specific 4,4′-methylene diphenyl diisocyanate hemoglobin adducts in human blood

Analytical and bioanalytical chemistry, 2013-09, Vol.405 (23), p.7205-7213

2013

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General pharmacokinetic model for drugs exhibiting target-mediated drug disposition

Journal of pharmacokinetics and pharmacodynamics, 2001-12, Vol.28 (6), p.507-532

2001

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Cross-sectional study on N,N-dimethylformamide (DMF); effects on liver and alcohol intolerance

International archives of occupational and environmental health, 2016-11, Vol.89 (8), p.1309-1320

2016

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A new method for simultaneous quantification of fosphenytoin, phenytoin and its primary metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin in whole blood by ultra-performance liquid chromatography-tandem mass spectrometry

Legal medicine (Tokyo, Japan), 2018-09, Vol.34, p.64-69

2018

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Serum accumulation of a creatinine oxidative metabolite (NZ-419: 5-hydroxy-1- methylhydatoin) as an intrinsic antioxidant in diabetic patients with or without chronic kidney disease

Clinical nephrology, 2011-10, Vol.76 (4), p.284

2011

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Saturable tissue binding and imirestat pharmacokinetics in rats

Pharmaceutical research, 1992-04, Vol.9 (4), p.469-473

1992

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Effect of protein binding on the high-performance liquid chromatography of phenytoin and imirestat in human serum by direct injection onto internal surface reversed-phase columns

Analytical chemistry (Washington), 1989-05, Vol.61 (10), p.1171-1174

1989

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Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography

Journal of chromatography, 1984-01, Vol.307 (1), p.121-127

1984

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Disposition of the Aldose Reductase Inhibitor AL01576 in Rats

Journal of pharmaceutical sciences, 1988-02, Vol.77 (2), p.110-115

1988

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A Pharmacokinetic Rationale for Three Times Daily Administration of Ethotoin (Peganone®)

Journal of clinical pharmacology, 1989-03, Vol.29 (3), p.270-271

1989

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Esters of Hydantoic Acids as Prodrugs of Hydantoins

Journal of pharmaceutical sciences, 1973-06, Vol.62 (6), p.962-967

1973

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The protein binding of phenytoin, propranolol, diazepam, and AL01576 (an aldose reductase inhibitor) in human and rat diabetic serum

Pharmaceutical research, 1988-05, Vol.5 (5), p.261-265

1988

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High-Performance Liquid Chromatographic Assay of the Aldose Reductase Inhibitor Spiro-(2-fluoro-9h-fluorene-9,4′-imidazolidine)-2′,5′-dione (AL01567) in Plasma and Urine and Its Pharmacokinetics in Humans

Journal of pharmaceutical sciences, 1988-07, Vol.77 (7), p.591-595

1988

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Ethotoin in seizures of childhood and adolescence

Neurology, 1984-06, Vol.34 (6), p.791

1984

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GC-NPD and GC-MS analysis of preserved tissue of Bhopal gas disaster: evidence of methyl carbamylation in post-mortem blood

Medicine, science, and the law, 1991-10, Vol.31 (4), p.289

1991

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Rapid and sensitive determination of ethotoin as well as carbamazepine, phenobarbital, phenytoin and primidone in human serum

Journal of chromatography, 1986, Vol.383 (1), p.166-171

1986

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Nonlinear ethotoin kinetics

Clinical pharmacology and therapeutics, 1983-03, Vol.33 (3), p.329-334

1983

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Clinical pharmacology of mephenytoin and ethotoin

Annals of neurology, 1979-11, Vol.6 (5), p.410-414

1979

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Simultaneous determination of enantioselective plasma protein binding of aminohydantoins by ultrafiltration and chiral high-performance liquid chromatography

Journal of chromatography. B, Biomedical sciences and applications, 1999-09, Vol.732 (1), p.31-37

1999

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Serum protein binding of AL01576, a new aldose reductase inhibitor

Pharmaceutical research, 1988-05, Vol.5 (5), p.319-321

1988

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Spiromustine Analogues. Relationships between Structure, Plasma Stability, and Antitumor Activity

Journal of pharmaceutical sciences, 1986-03, Vol.75 (3), p.313-316

1986

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Phenytoin intoxication induced by sulthiame in epileptic patients

Journal of neurology, neurosurgery and psychiatry, 1974-03, Vol.37 (3), p.275-281

1974

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Gas chromatographic determination of 5,5-diphenylhydantoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin in blood

Arzneimittel-Forschung, 1969-08, Vol.19 (8), p.1287

1969

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A Highly Selective Hydantoin Inhibitor of Aggrecanase‑1 and Aggrecanase‑2 with a Low Projected Human Dose

Determination of methyl isopropyl hydantoin from rat erythrocytes by gas-chromatography mass-spectrometry to determine methyl isocyanate dose following inhalation exposure

Analytical determination of specific 4,4′-methylene diphenyl diisocyanate hemoglobin adducts in human blood

General pharmacokinetic model for drugs exhibiting target-mediated drug disposition

Cross-sectional study on N,N-dimethylformamide (DMF); effects on liver and alcohol intolerance

A new method for simultaneous quantification of fosphenytoin, phenytoin and its primary metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin in whole blood by ultra-performance liquid chromatography-tandem mass spectrometry

Serum accumulation of a creatinine oxidative metabolite (NZ-419: 5-hydroxy-1- methylhydatoin) as an intrinsic antioxidant in diabetic patients with or without chronic kidney disease

Saturable tissue binding and imirestat pharmacokinetics in rats

Effect of protein binding on the high-performance liquid chromatography of phenytoin and imirestat in human serum by direct injection onto internal surface reversed-phase columns

Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography

Disposition of the Aldose Reductase Inhibitor AL01576 in Rats

A Pharmacokinetic Rationale for Three Times Daily Administration of Ethotoin (Peganone®)

Esters of Hydantoic Acids as Prodrugs of Hydantoins

The protein binding of phenytoin, propranolol, diazepam, and AL01576 (an aldose reductase inhibitor) in human and rat diabetic serum

High-Performance Liquid Chromatographic Assay of the Aldose Reductase Inhibitor Spiro-(2-fluoro-9h-fluorene-9,4′-imidazolidine)-2′,5′-dione (AL01567) in Plasma and Urine and Its Pharmacokinetics in Humans

Ethotoin in seizures of childhood and adolescence

GC-NPD and GC-MS analysis of preserved tissue of Bhopal gas disaster: evidence of methyl carbamylation in post-mortem blood

Rapid and sensitive determination of ethotoin as well as carbamazepine, phenobarbital, phenytoin and primidone in human serum

Nonlinear ethotoin kinetics

Clinical pharmacology of mephenytoin and ethotoin

Simultaneous determination of enantioselective plasma protein binding of aminohydantoins by ultrafiltration and chiral high-performance liquid chromatography

Serum protein binding of AL01576, a new aldose reductase inhibitor

Spiromustine Analogues. Relationships between Structure, Plasma Stability, and Antitumor Activity

Phenytoin intoxication induced by sulthiame in epileptic patients

Gas chromatographic determination of 5,5-diphenylhydantoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin in blood

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