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Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (43), p.17380-17385

2013

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Tumor Attenuation by Combined Heparan Sulfate and Polyamine Depletion

Proceedings of the National Academy of Sciences - PNAS, 2002-01, Vol.99 (1), p.371-376

2002

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Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

Oncogene, 2015-01, Vol.34 (3), p.290-302

2015

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Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4

PloS one, 2014-10, Vol.9 (10), p.e109596

2014

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Design of an Ultralow Molecular Weight Heparin That Resists Heparanase Biodegradation

Journal of medicinal chemistry, 2023-02, Vol.66 (3), p.2194-2203

2023

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Heparin, Heparan Sulphate and the TGF-β Cytokine Superfamily

Molecules (Basel, Switzerland), 2017-04, Vol.22 (5), p.713

2017

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Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)

Chemical communications (Cambridge, England), 2024-01, Vol.60 (4), p.436-439

2024

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Synthetic heparin and heparan sulfate: probes in defining biological functions

Current opinion in chemical biology, 2017-10, Vol.40, p.152-159

2017

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Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer's Disease

Chemistry : a European journal, 2013-05, Vol.19 (21), p.6817-6823

2013

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Synthesis of novel S - and O -disaccharide analogs of heparan sulfate for heparanase inhibition

Organic & biomolecular chemistry, 2022-05, Vol.20 (17), p.3528-3534

2022

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Heparan Sulfate: A Complex Polymer Charged with Biological Activity

Chemical reviews, 2005-07, Vol.105 (7), p.2745-2764

2005

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Modified cyclodextrins as broad-spectrum antivirals

Science advances, 2020-01, Vol.6 (5), p.eaax9318

2020

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Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host-cell interaction

Nature chemistry, 2011-06, Vol.3 (7), p.557-563

2011

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A Hexasaccharide Containing Rare 2‐O‐Sulfate‐Glucuronic Acid Residues Selectively Activates Heparin Cofactor II

Angewandte Chemie International Edition, 2017-02, Vol.56 (9), p.2312-2317

International ed. in English, 2017

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Glycosaminoglycan-directed cobalt complexes

Journal of inorganic biochemistry, 2023-08, Vol.245, p.112254-112254, Article 112254

2023

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The heparan sulfate mimetic Muparfostat aggravates steatohepatitis in obese mice due to its binding affinity to lipoprotein lipase

British journal of pharmacology, 2023-07, Vol.180 (14), p.1803-1818

2023

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In Situ Heparan Sulfate-Induced Peptide Self-Assembly to Overcome the Cell Surface Glycocalyx Barrier for Cancer Treatment

ACS applied materials & interfaces, 2024-09, Vol.16 (37), p.49013-49029

2024

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Thromboelastometry fails to detect autoheparinization after major trauma and hemorrhagic shock

The journal of trauma and acute care surgery, 2022-03, Vol.92 (3), p.535-541

2022

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Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor‑1 Interaction

Journal of the American Chemical Society, 2012-12, Vol.134 (51), p.20722-20727

2012

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A Single-Amino-Acid Polymorphism in Chikungunya Virus E2 Glycoprotein Influences Glycosaminoglycan Utilization

Journal of Virology, 2014-03, Vol.88 (5), p.2385-2397

2014

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Heparan sulfate binds the extracellular Annexin A1 and blocks its effects on pancreatic cancer cells

Biochemical pharmacology, 2020-12, Vol.182, p.114252-114252, Article 114252

2020

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Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Nature communications, 2021-06, Vol.12 (1), p.3495-17, Article 3495

2021

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Convergent chemoenzymatic synthesis and biological evaluation of a heparan sulfate proteoglycan syndecan-1 mimetic

Chemical communications (Cambridge, England), 2021-04, Vol.57 (27), p.347-341

2021

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A Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2)

Biomacromolecules, 2016-10, Vol.17 (10), p.3386-3395

2016

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Discovery of small-molecule protein stabilizers toward exogenous alpha-l-iduronidase to reduce the accumulated heparan sulfate in mucopolysaccharidosis type I cells

European journal of medicinal chemistry, 2023-02, Vol.247, p.115005-115005, Article 115005

2023

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Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

Tumor Attenuation by Combined Heparan Sulfate and Polyamine Depletion

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4

Design of an Ultralow Molecular Weight Heparin That Resists Heparanase Biodegradation

Heparin, Heparan Sulphate and the TGF-β Cytokine Superfamily

Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)

Synthetic heparin and heparan sulfate: probes in defining biological functions

Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer's Disease

Synthesis of novel S - and O -disaccharide analogs of heparan sulfate for heparanase inhibition

Heparan Sulfate: A Complex Polymer Charged with Biological Activity

Modified cyclodextrins as broad-spectrum antivirals

Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host-cell interaction

A Hexasaccharide Containing Rare 2‐O‐Sulfate‐Glucuronic Acid Residues Selectively Activates Heparin Cofactor II

Glycosaminoglycan-directed cobalt complexes

The heparan sulfate mimetic Muparfostat aggravates steatohepatitis in obese mice due to its binding affinity to lipoprotein lipase

In Situ Heparan Sulfate-Induced Peptide Self-Assembly to Overcome the Cell Surface Glycocalyx Barrier for Cancer Treatment

Thromboelastometry fails to detect autoheparinization after major trauma and hemorrhagic shock

Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor‑1 Interaction

A Single-Amino-Acid Polymorphism in Chikungunya Virus E2 Glycoprotein Influences Glycosaminoglycan Utilization

Heparan sulfate binds the extracellular Annexin A1 and blocks its effects on pancreatic cancer cells

Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Convergent chemoenzymatic synthesis and biological evaluation of a heparan sulfate proteoglycan syndecan-1 mimetic

A Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2)

Discovery of small-molecule protein stabilizers toward exogenous alpha-l-iduronidase to reduce the accumulated heparan sulfate in mucopolysaccharidosis type I cells

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