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The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Frontiers in cell and developmental biology, 2020-09, Vol.8, p.576946-576946

2020

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Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment

European journal of medicinal chemistry, 2020-12, Vol.208, p.112831-112831, Article 112831

2020

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Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Genes, 2020-05, Vol.11 (5), p.556

2020

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Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

Clinical epigenetics, 2012-03, Vol.4 (1), p.5-5, Article 5

2012

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HDAC Inhibitor Sodium Butyrate-Mediated Epigenetic Regulation Enhances Neuroprotective Function of Microglia During Ischemic Stroke

Molecular neurobiology, 2017-10, Vol.54 (8), p.6391-6411

2017

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The epigenetic changes are affected by sex and valproic acid treatment in a rat model of post-traumatic stress disorder

Neuroscience letters, 2024-09, Vol.839, p.137957, Article 137957

2024

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Advances in the Design and Development of PROTAC-mediated HDAC Degradation

Current topics in medicinal chemistry, 2022-03, Vol.22 (5), p.408-424

2022

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HDAC inhibitors: Targets for tumor therapy, immune modulation and lung diseases

Translational oncology, 2022-02, Vol.16, p.101312-101312, Article 101312

2022

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Enhancement of Histone Deacetylase Inhibitor Sensitivity in Combination with Cyclin-Dependent Kinase Inhibition for the Treatment of Oral Squamous Cell Carcinoma

Cellular physiology and biochemistry, 2019, Vol.53 (1), p.141-156

2019

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dCas9-HDAC8-EGFP fusion enables epigenetic editing of breast cancer cells by H3K9 deacetylation

European journal of cell biology, 2024-12, Vol.103 (4), p.151463, Article 151463

2024

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Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening

European journal of medicinal chemistry, 2020-04, Vol.192, p.112189, Article 112189

2020

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Molecular docking, synthesis, characteristics and preliminary cytotoxic study of new coumarin-sulfonamide derivatives as histone deacetylase inhibitors

Wiadomości lekarskie (1960), 2024-01, Vol.77 (3), p.514-525

2024

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New Insight in HDACs: Potential Therapeutic Targets for the Treatment of Atherosclerosis

Frontiers in pharmacology, 2022-04, Vol.13, p.863677-863677

2022

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HDAC inhibitors as antifibrotic drugs in cardiac and pulmonary fibrosis

Therapeutic Advances in Chronic Disease, 2019, Vol.10, p.2040622319862697-2040622319862697

2019

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Role of microbiota-derived short-chain fatty acids in cancer development and prevention

Biomedicine & pharmacotherapy, 2021-07, Vol.139, p.111619-111619, Article 111619

2021

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Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity

European journal of medicinal chemistry, 2022-11, Vol.241, p.114634-114634, Article 114634

2022

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An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential

Cell, 2018-05, Vol.173 (6), p.1413-1425.e14

2018

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HDAC family: What are the cancer relevant targets?

Cancer letters, 2009-05, Vol.277 (1), p.8-21

2009

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Chemical interplay between gut microbiota and epigenetics: Implications in circadian biology

Cell chemical biology, 2024-05

2024

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Non-histone substrates of histone deacetylases as potential therapeutic targets in epilepsy

Expert opinion on therapeutic targets, 2021-01, Vol.25 (1), p.75-85

2021

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Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat

European journal of medicinal chemistry, 2018-10, Vol.158, p.593-619

2018

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Anticancer properties of chimeric HDAC and kinase inhibitors

Seminars in cancer biology, 2022-08, Vol.83, p.472-486

2022

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Recent developments of HDAC inhibitors: Emerging indications and novel molecules

British journal of clinical pharmacology, 2021-12, Vol.87 (12), p.4577-4597

2021

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Histone deacetylase inhibitors as antidiabetic agents: Advances and opportunities

European journal of pharmacology, 2022-11, Vol.935, p.175328-175328, Article 175328

2022

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Synthesis of new pyridine based ONNO type schiff bases and Cd(II) complexes, investigation of structural, electronic and anti-cancer properties as computationally and experimentally

Journal of molecular structure, 2025-02, Vol.1322, p.140359, Article 140359

2025

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The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

HDAC Inhibitor Sodium Butyrate-Mediated Epigenetic Regulation Enhances Neuroprotective Function of Microglia During Ischemic Stroke

The epigenetic changes are affected by sex and valproic acid treatment in a rat model of post-traumatic stress disorder

Advances in the Design and Development of PROTAC-mediated HDAC Degradation

HDAC inhibitors: Targets for tumor therapy, immune modulation and lung diseases

Enhancement of Histone Deacetylase Inhibitor Sensitivity in Combination with Cyclin-Dependent Kinase Inhibition for the Treatment of Oral Squamous Cell Carcinoma

dCas9-HDAC8-EGFP fusion enables epigenetic editing of breast cancer cells by H3K9 deacetylation

Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening

Molecular docking, synthesis, characteristics and preliminary cytotoxic study of new coumarin-sulfonamide derivatives as histone deacetylase inhibitors

New Insight in HDACs: Potential Therapeutic Targets for the Treatment of Atherosclerosis

HDAC inhibitors as antifibrotic drugs in cardiac and pulmonary fibrosis

Role of microbiota-derived short-chain fatty acids in cancer development and prevention

Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential

HDAC family: What are the cancer relevant targets?

Chemical interplay between gut microbiota and epigenetics: Implications in circadian biology

Non-histone substrates of histone deacetylases as potential therapeutic targets in epilepsy

Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat

Anticancer properties of chimeric HDAC and kinase inhibitors

Recent developments of HDAC inhibitors: Emerging indications and novel molecules

Histone deacetylase inhibitors as antidiabetic agents: Advances and opportunities

Synthesis of new pyridine based ONNO type schiff bases and Cd(II) complexes, investigation of structural, electronic and anti-cancer properties as computationally and experimentally

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