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The evolutionary divergence of receptor guanylyl cyclase C has implications for preclinical models for receptor-directed therapeutics

The Journal of biological chemistry, 2024-01, Vol.300 (1), p.105505-105505, Article 105505

2024

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NMR Structure of Retinal Guanylate Cyclase Activating Protein 5 (GCAP5) with R22A Mutation That Abolishes Dimerization and Enhances Cyclase Activation

Biochemistry (Easton), 2024-05, Vol.63 (10), p.1246-1256

2024

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A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration

The Journal of biological chemistry, 2019-03, Vol.294 (10), p.3476-3488

2019

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GUCY2D Cone-Rod Dystrophy-6 Is a "Phototransduction Disease" Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1

The Journal of neuroscience, 2018-03, Vol.38 (12), p.2990-3000

2018

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Molecular Properties of Human Guanylate Cyclase-Activating Protein 3 (GCAP3) and Its Possible Association with Retinitis Pigmentosa

International journal of molecular sciences, 2022-03, Vol.23 (6), p.3240

2022

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Two clusters of surface-exposed amino acid residues enable high-affinity binding of retinal degeneration-3 (RD3) protein to retinal guanylyl cyclase

The Journal of biological chemistry, 2020-07, Vol.295 (31), p.10781-10793

2020

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Absence of Receptor Guanylyl Cyclase C Enhances Ileal Damage and Reduces Cytokine and Antimicrobial Peptide Production during Oral Salmonella enterica Serovar Typhimurium Infection

Infection and immunity, 2018-05, Vol.86 (5)

2018

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Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases

Pharmacology & therapeutics (Oxford), 2011-04, Vol.130 (1), p.71-82

Potter, Lincoln R

2011

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Structure of Guanylyl Cyclase Activator Protein 1 (GCAP1) Mutant V77E in a Ca2+-free/Mg2+-bound Activator State

The Journal of biological chemistry, 2016-02, Vol.291 (9), p.4429-4441

2016

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Evaluating the Role of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Domains in Binding Guanylyl Cyclase-activating Proteins (GCAPs)

The Journal of biological chemistry, 2015-03, Vol.290 (11), p.6913-6924

2015

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Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system

The Journal of clinical investigation, 2006-06, Vol.116 (6), p.1731-1737

2006

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Dimerization Domain of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Is an Essential Part of Guanylyl Cyclase-activating Protein (GCAP) Binding Interface

The Journal of biological chemistry, 2015-08, Vol.290 (32), p.19584-19596

2015

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Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness

The Journal of biological chemistry, 2019-09, Vol.294 (37), p.13729-13739

2019

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Structural Characterization of Ferrous Ion Binding to Retinal Guanylate Cyclase Activator Protein 5 from Zebrafish Photoreceptors

Biochemistry (Easton), 2017-12, Vol.56 (51), p.6652-6661

2017

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Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans

Proceedings of the National Academy of Sciences - PNAS, 2011-01, Vol.108 (1), p.254-259

2011

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High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor

The Journal of cell biology, 2014-08, Vol.206 (4), p.541-557

2014

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Impaired Association of Retinal Degeneration-3 with Guanylate Cyclase-1 and Guanylate Cyclase-activating Protein-1 Leads to Leber Congenital Amaurosis-1

The Journal of biological chemistry, 2015-02, Vol.290 (6), p.3488-3499

2015

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Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology

Clinical pharmacology and therapeutics, 2016-04, Vol.99 (4), p.360-362

2016

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Two retinal dystrophy-associated missense mutations in GUCA1A with distinct molecular properties result in a similar aberrant regulation of the retinal guanylate cyclase

Human molecular genetics, 2015-12, Vol.24 (23), p.6653-6666

2015

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Lateralized Gustatory Behavior of C. elegans Is Controlled by Specific Receptor-Type Guanylyl Cyclases

Current biology, 2009-06, Vol.19 (12), p.996-1004

2009

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Effect of guanylate cyclase-C activity on energy and glucose homeostasis

Diabetes (New York, N.Y.), 2014-11, Vol.63 (11), p.3798-3804

2014

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RD3 gene delivery restores guanylate cyclase localization and rescues photoreceptors in the Rd3 mouse model of Leber congenital amaurosis 12

Human molecular genetics, 2013-10, Vol.22 (19), p.3894-3905

2013

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Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice

PloS one, 2012-10, Vol.7 (10), p.e47637-e47637

2012

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Neuronal Calcium Sensor GCAP1 Encoded by GUCA1A Exhibits Heterogeneous Functional Properties in Two Cases of Retinitis Pigmentosa

ACS chemical neuroscience, 2020-05, Vol.11 (10), p.1458-1470

2020

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Identification of Target Binding Site in Photoreceptor Guanylyl Cyclase-activating Protein 1 (GCAP1)

The Journal of biological chemistry, 2014-04, Vol.289 (14), p.10140-10154

2014

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