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Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells

Biology of the cell, 2008-11, Vol.100 (11), p.645-661

2008

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DOCK8 is expressed in microglia, and it regulates microglial activity during neurodegeneration in murine disease models

The Journal of biological chemistry, 2019-09, Vol.294 (36), p.13421-13433

2019

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Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac

The Journal of biological chemistry, 2012-12, Vol.287 (53), p.44192-44202

2012

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Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1

The Journal of biological chemistry, 2022-08, Vol.298 (8), p.102209-102209, Article 102209

2022

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Fluorescence Intensity-Based eIF2B's Guanine Nucleotide-Exchange Factor Activity Assay

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2428, p.187

2022

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The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101579-101579, Article 101579

2022

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RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state

The Journal of biological chemistry, 2024-07, Vol.300 (7), p.107459, Article 107459

2024

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Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel

The Journal of biological chemistry, 2019-06, Vol.294 (25), p.9937-9948

2019

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The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

The Journal of biological chemistry, 2020-09, Vol.295 (36), p.12635-12647

2020

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Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells

The Journal of biological chemistry, 2019-10, Vol.294 (42), p.15446-15465

2019

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The BLOC-3 subunit HPS4 is required for activation of Rab32/38 GTPases in melanogenesis, but its Rab9 activity is dispensable for melanogenesis

The Journal of biological chemistry, 2019-04, Vol.294 (17), p.6912-6922

2019

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Targeting Rac and Cdc42 GEFs in Metastatic Cancer

Frontiers in cell and developmental biology, 2020-04, Vol.8, p.201-201

2020

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The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block

Cell cycle (Georgetown, Tex.), 2017-04, Vol.16 (7), p.607-612

2017

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Identification of novel neuronal isoforms of the Rho-GEF Trio

Biology of the cell, 2006-03, Vol.98 (3), p.183-193

2006

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Molecular modeling of ARF6 dysregulation caused by mutations in IQSEC2

Journal of biomolecular structure & dynamics, 2024-02, Vol.42 (3), p.1268-1279

2024

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Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI

The Journal of biological chemistry, 2018-06, Vol.293 (22), p.8521-8529

2018

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The Parkinson's disease–associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages

The Journal of biological chemistry, 2020-07, Vol.295 (31), p.10857-10867

2020

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The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells

The Journal of biological chemistry, 2015-08, Vol.290 (34), p.20827-20840

2015

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The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain

The Journal of biological chemistry, 2017-10, Vol.292 (43), p.17777-17793

2017

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cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits

The Journal of biological chemistry, 2019-02, Vol.294 (7), p.2232-2246

2019

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DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi

The Journal of biological chemistry, 2020-02, Vol.295 (8), p.2270-2284

2020

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Roles of the DOCK-D family proteins in a mouse model of neuroinflammation

The Journal of biological chemistry, 2020-05, Vol.295 (19), p.6710-6720

2020

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Targeting of the Arf-GEF GBF1 to lipid droplets and Golgi membranes

Journal of cell science, 2013-10, Vol.126 (Pt 20), p.4794-4805

2013

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A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy

The Journal of biological chemistry, 2018-03, Vol.293 (12), p.4566-4574

2018

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DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction

The Journal of biological chemistry, 2017-02, Vol.292 (6), p.2191-2202

2017

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Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells

DOCK8 is expressed in microglia, and it regulates microglial activity during neurodegeneration in murine disease models

Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac

Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1

Fluorescence Intensity-Based eIF2B's Guanine Nucleotide-Exchange Factor Activity Assay

The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN

RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state

Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel

The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells

The BLOC-3 subunit HPS4 is required for activation of Rab32/38 GTPases in melanogenesis, but its Rab9 activity is dispensable for melanogenesis

Targeting Rac and Cdc42 GEFs in Metastatic Cancer

The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block

Identification of novel neuronal isoforms of the Rho-GEF Trio

Molecular modeling of ARF6 dysregulation caused by mutations in IQSEC2

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI

The Parkinson's disease–associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells

The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits

DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi

Roles of the DOCK-D family proteins in a mouse model of neuroinflammation

Targeting of the Arf-GEF GBF1 to lipid droplets and Golgi membranes

A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy

DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction

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