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Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation

The Journal of clinical investigation, 2021-12, Vol.131 (24), p.1-18

2021

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Chimerism, the Microenvironment and Control of Leukemia

Frontiers in immunology, 2021-04, Vol.12, p.652105

Deeg, H Joachim

2021

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Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity

The Journal of clinical investigation, 2017-06, Vol.127 (7), p.2765-2776

2017

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Graft-versus-host disease is enhanced by selective CD73 blockade in mice

PloS one, 2013-03, Vol.8 (3), p.e58397-e58397

2013

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Graft-versus-leukemia effects of transplantation and donor lymphocytes

Blood, 2008-12, Vol.112 (12), p.4371-4383

Kolb, Hans-Jochem

2008

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Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response

The Journal of clinical investigation, 2017-02, Vol.127 (2), p.517-529

2017

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Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice

Blood, 2019-01, Vol.133 (3), p.266-279

2019

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PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells

The Journal of clinical investigation, 2017-05, Vol.127 (5), p.1960-1977

2017

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T-cell-replete haploidentical HSCT with low-dose anti-T-lymphocyte globulin compared with matched sibling HSCT and unrelated HSCT

Blood, 2014-10, Vol.124 (17), p.2735-2743

2014

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Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice

The Journal of clinical investigation, 2024-08, Vol.134 (16), p.1-16

2024

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Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation

The New England journal of medicine, 2009-07, Vol.361 (5), p.478-488

2009

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Improved survival outcomes and restoration of graft‐vs‐leukemia effect by deferasirox after allogeneic stem cell transplantation in acute myeloid leukemia

Cancer medicine (Malden, MA), 2019-02, Vol.8 (2), p.501-514

2019

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IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling

Blood, 2019-12, Vol.134 (23), p.2092-2106

2019

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Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity

Blood, 2009-03, Vol.113 (13), p.3119-3129

2009

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ATG5-Dependent Autophagy Uncouples T-cell Proliferative and Effector Functions and Separates Graft-versus-Host Disease from Graft-versus-Leukemia

Cancer research (Chicago, Ill.), 2021-02, Vol.81 (4), p.1063-1075

2021

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MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice

Blood, 2015-09, Vol.126 (11), p.1314-1323

2015

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Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (4), p.1125-1130

2015

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Kras-Deficient T Cells Attenuate Graft-versus-Host Disease but Retain Graft-versus-Leukemia Activity

The Journal of immunology (1950), 2020-12, Vol.205 (12), p.3480-3490

2020

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Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT

Frontiers in immunology, 2020-11, Vol.11, p.593863-593863

2020

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Type I-IFNs control GVHD and GVL responses after transplantation

Blood, 2011-09, Vol.118 (12), p.3399-3409

2011

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Donor APCs are required for maximal GVHD but not for GVL

Nature medicine, 2004-09, Vol.10 (9), p.987-992

2004

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KIR and HLA genotypes predictive of low-affinity interactions are associated with lower relapse in autologous hematopoietic cell transplantation for acute myeloid leukemia

The Journal of immunology (1950), 2015-05, Vol.194 (9), p.4222-4230

2015

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Donor γδT Cells Promote GVL Effect and Mitigate aGVHD in Allogeneic Hematopoietic Stem Cell Transplantation

Frontiers in immunology, 2020-10, Vol.11, p.558143-558143

2020

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Can Graft vs. Leukemia Effect Be Uncoupled From Graft vs. Host Disease? An Examination of Proportions

Frontiers in immunology, 2020-04, Vol.11, p.777-777

2020

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Molecules and mechanisms of the graft-versus-leukaemia effect

Nature reviews. Cancer, 2004-05, Vol.4 (5), p.371-380

2004

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Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation

Chimerism, the Microenvironment and Control of Leukemia

Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity

Graft-versus-host disease is enhanced by selective CD73 blockade in mice

Graft-versus-leukemia effects of transplantation and donor lymphocytes

Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response

Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice

PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells

T-cell-replete haploidentical HSCT with low-dose anti-T-lymphocyte globulin compared with matched sibling HSCT and unrelated HSCT

Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice

Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation

Improved survival outcomes and restoration of graft‐vs‐leukemia effect by deferasirox after allogeneic stem cell transplantation in acute myeloid leukemia

IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling

Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity

ATG5-Dependent Autophagy Uncouples T-cell Proliferative and Effector Functions and Separates Graft-versus-Host Disease from Graft-versus-Leukemia

MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice

Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity

Kras-Deficient T Cells Attenuate Graft-versus-Host Disease but Retain Graft-versus-Leukemia Activity

Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT

Type I-IFNs control GVHD and GVL responses after transplantation

Donor APCs are required for maximal GVHD but not for GVL

KIR and HLA genotypes predictive of low-affinity interactions are associated with lower relapse in autologous hematopoietic cell transplantation for acute myeloid leukemia

Donor γδT Cells Promote GVL Effect and Mitigate aGVHD in Allogeneic Hematopoietic Stem Cell Transplantation

Can Graft vs. Leukemia Effect Be Uncoupled From Graft vs. Host Disease? An Examination of Proportions

Molecules and mechanisms of the graft-versus-leukaemia effect

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