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Peptidomimetic α‑Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV‑2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2905-2925

2022

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Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV‑2 3CLpro)

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2880-2904

2022

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Proline-dependent regulation of collagen metabolism

Cellular and molecular life sciences : CMLS, 2020-05, Vol.77 (10), p.1911-1918

2020

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Biomimetic Nanoplatform Loading Type I Aggregation-Induced Emission Photosensitizer and Glutamine Blockade to Regulate Nutrient Partitioning for Enhancing Antitumor Immunotherapy

ACS nano, 2022-07, Vol.16 (7), p.10742-10753

2022

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Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion

Cell metabolism, 2021-04, Vol.33 (4), p.804-817.e5

2021

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Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

Cell reports (Cambridge), 2017-01, Vol.18 (4), p.991-1004

2017

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Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

Cancer cell, 2013-10, Vol.24 (4), p.450-465

2013

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Determination of the anti-inflammatory and cytoprotective effects of l-glutamine and l-alanine, or dipeptide, supplementation in rats submitted to resistance exercise

British journal of nutrition, 2016-08, Vol.116 (3), p.470-479

2016

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Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

The Journal of biological chemistry, 2014-09, Vol.289 (36), p.25010-25020

2014

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Dual Inhibitions on Glucose/Glutamine Metabolisms for Nontoxic Pancreatic Cancer Therapy

ACS applied materials & interfaces, 2022-05, Vol.14 (19), p.21836-21847

2022

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Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation

The Journal of immunology (1950), 2010-07, Vol.185 (2), p.1037-1044

2010

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Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

Genes & development, 2016-08, Vol.30 (15), p.1704-1717

2016

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A redox-responsive prodrug for tumor-targeted glutamine restriction

Journal of controlled release, 2024-04, Vol.368, p.251-264

2024

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Are Smaller Nanoparticles Always Better? Understanding the Biological Effect of Size-Dependent Silver Nanoparticle Aggregation Under Biorelevant Conditions

International journal of nanomedicine, 2021-01, Vol.16, p.3021-3040

2021

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Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

Nature communications, 2020-07, Vol.11 (1), p.3326-15, Article 3326

2020

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Long-term cadmium exposure induces epithelial-mesenchymal transition in breast cancer cells by activating CYP1B1-mediated glutamine metabolic reprogramming in BT474 cells and MMTV-Erbb2 mice

The Science of the total environment, 2024-03, Vol.918, p.170773-170773, Article 170773

2024

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Glutamine and intestinal barrier function

Amino Acids, 2015-10, Vol.47 (10), p.2143-2154

2015

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Glutamine alleviates heat stress-induced impairment of intestinal morphology, intestinal inflammatory response, and barrier integrity in broilers

Poultry science, 2018-08, Vol.97 (8), p.2675-2683

2018

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Phenotype microarray analysis reveals the biotransformation of Fusarium oxysporum f.sp. lycopersici influenced by Bacillus subtilis PBE-8 metabolites

FEMS microbiology ecology, 2022-10, Vol.98 (10)

2022

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Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy

Nutrients, 2020-06, Vol.12 (6), p.1675

2020

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Glutamate alleviates cadmium toxicity in rice via suppressing cadmium uptake and translocation

Journal of hazardous materials, 2020-02, Vol.384, p.121319, Article 121319

2020

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Protective effect of glutamine and arginine against soybean meal-induced enteritis in the juvenile turbot (Scophthalmus maximus)

Fish & shellfish immunology, 2017-11, Vol.70, p.95-105

2017

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Oral post-treatment supplementation with a combination of glutamine, citrulline, and antioxidant vitamins additively mitigates jejunal damage, oxidative stress, and inflammation in rats with intestinal ischemia and reperfusion

PloS one, 2024-02, Vol.19 (2), p.e0298334-e0298334

2024

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Glucose- and glutamine-dependent bioenergetics sensitize bone mechanoresponse after unloading by modulating osteocyte calcium dynamics

The Journal of clinical investigation, 2023-02, Vol.133 (3), p.1-19

2023

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ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides

Gastroenterology (New York, N.Y. 1943), 2019-03, Vol.156 (4), p.1098-1111

2019

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Peptidomimetic α‑Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV‑2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability

Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV‑2 3CLpro)

Proline-dependent regulation of collagen metabolism

Biomimetic Nanoplatform Loading Type I Aggregation-Induced Emission Photosensitizer and Glutamine Blockade to Regulate Nutrient Partitioning for Enhancing Antitumor Immunotherapy

Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

Determination of the anti-inflammatory and cytoprotective effects of l-glutamine and l-alanine, or dipeptide, supplementation in rats submitted to resistance exercise

Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

Dual Inhibitions on Glucose/Glutamine Metabolisms for Nontoxic Pancreatic Cancer Therapy

Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

A redox-responsive prodrug for tumor-targeted glutamine restriction

Are Smaller Nanoparticles Always Better? Understanding the Biological Effect of Size-Dependent Silver Nanoparticle Aggregation Under Biorelevant Conditions

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

Long-term cadmium exposure induces epithelial-mesenchymal transition in breast cancer cells by activating CYP1B1-mediated glutamine metabolic reprogramming in BT474 cells and MMTV-Erbb2 mice

Glutamine and intestinal barrier function

Glutamine alleviates heat stress-induced impairment of intestinal morphology, intestinal inflammatory response, and barrier integrity in broilers

Phenotype microarray analysis reveals the biotransformation of Fusarium oxysporum f.sp. lycopersici influenced by Bacillus subtilis PBE-8 metabolites

Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy

Glutamate alleviates cadmium toxicity in rice via suppressing cadmium uptake and translocation

Protective effect of glutamine and arginine against soybean meal-induced enteritis in the juvenile turbot (Scophthalmus maximus)

Oral post-treatment supplementation with a combination of glutamine, citrulline, and antioxidant vitamins additively mitigates jejunal damage, oxidative stress, and inflammation in rats with intestinal ischemia and reperfusion

Glucose- and glutamine-dependent bioenergetics sensitize bone mechanoresponse after unloading by modulating osteocyte calcium dynamics

ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides

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