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Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4-A Case Study with Midazolam

Drug metabolism and disposition, 2024-06, Vol.52 (7), p.614

2024

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Quantitative Proteomics and Mechanistic Modeling of Transporter‐Mediated Disposition in Nonalcoholic Fatty Liver Disease

Clinical pharmacology and therapeutics, 2020-05, Vol.107 (5), p.1128-1137

2020

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Pharmacokinetics, Pharmacodynamics, and PKPD Modeling of Curcumin in Regulating Antioxidant and Epigenetic Gene Expression in Healthy Human Volunteers

Molecular pharmaceutics, 2019-05, Vol.16 (5), p.1881-1889

2019

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Validation of a rapid and sensitive LC-MS/MS method for determination of exemestane and its metabolites, 17β-hydroxyexemestane and 17β-hydroxyexemestane-17-O-β-D-glucuronide: application to human pharmacokinetics study

PloS one, 2015-03, Vol.10 (3), p.e0118553-e0118553

2015

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Transfer of bisphenol A across the human placenta

American journal of obstetrics and gynecology, 2010-04, Vol.202 (4), p.393.e1-393.e7

2010

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Orange juice (poly)phenols are highly bioavailable in humans

The American journal of clinical nutrition, 2014-11, Vol.100 (5), p.1378-1384

2014

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Molecular, Macromolecular, and Supramolecular Glucuronide Prodrugs: Lead Identified for Anticancer Prodrug Monotherapy

Angewandte Chemie International Edition, 2020-05, Vol.59 (19), p.7390-7396

International ed. in English, 2020

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Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults

Clinical pharmacokinetics, 2017-12, Vol.56 (12), p.1543-1554

2017

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Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database

Molecular nutrition & food research, 2016-01, Vol.60 (1), p.203-211

2016

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A rapid ultra high performance liquid chromatography–tandem mass spectrometry method for the quantification of daidzein, its valine carbamate prodrug, and glucuronide in rat plasma samples: Comparison of the pharmacokinetic behavior of daidzine valine carbamate prodrugs

Journal of separation science, 2021-10, Vol.44 (19), p.3691-3699

2021

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Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies

Journal of pharmaceutical and biomedical analysis, 2014-08, Vol.97, p.9-23

2014

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High bioavailability of bisphenol A from sublingual exposure

Environmental health perspectives, 2013-08, Vol.121 (8), p.951-956

2013

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Pharmacokinetics and Pharmacodynamics of Canagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, in Subjects With Type 2 Diabetes Mellitus

Journal of clinical pharmacology, 2013-06, Vol.53 (6), p.601-610

2013

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Population Pharmacokinetics of Lamotrigine and Its N2-Glucuronide Metabolite in Chinese Patients With Epilepsy

Therapeutic drug monitoring, 2024-10, Vol.46 (5), p.649-657

2024

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A positive–negative switching LC-MS/MS method for quantification of fenoldopam and its phase II metabolites: Applications to a pharmacokinetic study in rats

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021-08, Vol.1179, p.122854-122854, Article 122854

2021

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Development and validation of an UPLC–MS/MS method for the quantification of irinotecan, SN-38 and SN-38 glucuronide in plasma, urine, feces, liver and kidney: Application to a pharmacokinetic study of irinotecan in rats

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016-03, Vol.1015-1016, p.34-41

2016

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Oral pharmacokinetics of baicalin, wogonoside, oroxylin A 7-O-β-d-glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016-07, Vol.1026, p.124-133

2016

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Acyl glucuronides: the good, the bad and the ugly

Biopharmaceutics & drug disposition, 2010-10, Vol.31 (7), p.367-395

2010

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Development of LC–MS/MS methodology for the detection/determination and confirmation of chloramphenicol, chloramphenicol 3-O-β-d-glucuronide, florfenicol, florfenicol amine and thiamphenicol residues in bovine, equine and porcine liver

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015-06, Vol.991, p.68-78

2015

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Determination of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study

Journal of separation science, 2020-06, Vol.43 (12), p.2290-2300

2020

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Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood

Biological and Pharmaceutical Bulletin, 2017/09/01, Vol.40(9), pp.1515-1524

2017

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Decrease in the oral bioavailability of dabigatran etexilate after co‐medication with rifampicin

British journal of clinical pharmacology, 2012-09, Vol.74 (3), p.490-500

2012

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Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice

International immunopharmacology, 2020-09, Vol.86, p.106723, Article 106723

2020

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Pharmacokinetics of Cajaninstilbene Acid and Its Main Glucuronide Metabolite in Rats

Journal of agricultural and food chemistry, 2017-05, Vol.65 (20), p.4066-4073

2017

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Liquid chromatography‐tandem mass spectrometry assay for the simultaneous determination of three major flavonoids and their glucuronidated metabolites in rats after oral administration of Artemisia annua L. extract at a therapeutic ultra‐low dose

Journal of separation science, 2019-11, Vol.42 (21), p.3330-3339

2019

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Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4-A Case Study with Midazolam

Quantitative Proteomics and Mechanistic Modeling of Transporter‐Mediated Disposition in Nonalcoholic Fatty Liver Disease

Pharmacokinetics, Pharmacodynamics, and PKPD Modeling of Curcumin in Regulating Antioxidant and Epigenetic Gene Expression in Healthy Human Volunteers

Validation of a rapid and sensitive LC-MS/MS method for determination of exemestane and its metabolites, 17β-hydroxyexemestane and 17β-hydroxyexemestane-17-O-β-D-glucuronide: application to human pharmacokinetics study

Transfer of bisphenol A across the human placenta

Orange juice (poly)phenols are highly bioavailable in humans

Molecular, Macromolecular, and Supramolecular Glucuronide Prodrugs: Lead Identified for Anticancer Prodrug Monotherapy

Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults

Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database

A rapid ultra high performance liquid chromatography–tandem mass spectrometry method for the quantification of daidzein, its valine carbamate prodrug, and glucuronide in rat plasma samples: Comparison of the pharmacokinetic behavior of daidzine valine carbamate prodrugs

Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies

High bioavailability of bisphenol A from sublingual exposure

Pharmacokinetics and Pharmacodynamics of Canagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, in Subjects With Type 2 Diabetes Mellitus

Population Pharmacokinetics of Lamotrigine and Its N2-Glucuronide Metabolite in Chinese Patients With Epilepsy

A positive–negative switching LC-MS/MS method for quantification of fenoldopam and its phase II metabolites: Applications to a pharmacokinetic study in rats

Development and validation of an UPLC–MS/MS method for the quantification of irinotecan, SN-38 and SN-38 glucuronide in plasma, urine, feces, liver and kidney: Application to a pharmacokinetic study of irinotecan in rats

Oral pharmacokinetics of baicalin, wogonoside, oroxylin A 7-O-β-d-glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat

Acyl glucuronides: the good, the bad and the ugly

Development of LC–MS/MS methodology for the detection/determination and confirmation of chloramphenicol, chloramphenicol 3-O-β-d-glucuronide, florfenicol, florfenicol amine and thiamphenicol residues in bovine, equine and porcine liver

Determination of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study

Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood

Decrease in the oral bioavailability of dabigatran etexilate after co‐medication with rifampicin

Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice

Pharmacokinetics of Cajaninstilbene Acid and Its Main Glucuronide Metabolite in Rats

Liquid chromatography‐tandem mass spectrometry assay for the simultaneous determination of three major flavonoids and their glucuronidated metabolites in rats after oral administration of Artemisia annua L. extract at a therapeutic ultra‐low dose

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