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Molecular and cellular regulation of human glucokinase

Archives of biochemistry and biophysics, 2019-03, Vol.663, p.199-213

2019

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Hormonal and Metabolite Regulation of Hepatic Glucokinase

Annual review of nutrition, 2016-07, Vol.36 (1), p.389-415

Agius, Loranne

2016

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Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of comparative neurology (1911), 2022-08, Vol.530 (11), p.1773-1949

2022

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Characterizing glucokinase variant mechanisms using a multiplexed abundance assay

Genome Biology, 2024-04, Vol.25 (1), p.98-22, Article 98

2024

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Mutational analysis of allosteric activation and inhibition of glucokinase

Biochemical journal, 2011-12, Vol.440 (2), p.203-215

2011

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Glucokinase activity in diabetes: too much of a good thing?

Trends in endocrinology and metabolism, 2023-02, Vol.34 (2), p.119-130

2023

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Elucidating the Glucokinase Activating Potentials of Naturally Occurring Prenylated Flavonoids: An Explicit Computational Approach

Molecules (Basel, Switzerland), 2021-11, Vol.26 (23), p.7211

2021

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Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes

Mini reviews in medicinal chemistry, 2024-01, Vol.24 (7), p.674-688

2024

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Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice

Diabetes, obesity & metabolism, 2022-03, Vol.24 (3), p.391-401

2022

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Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice

Molecular metabolism (Germany), 2021-11, Vol.53, p.101311-101311, Article 101311

2021

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Liver glucokinase: An overview on the regulatorymechanisms of its activity

IUBMB life, 2011-01, Vol.63 (1), p.1-6

2011

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Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study

Cardiovascular diabetology, 2024-06, Vol.23 (1), p.228-11, Article 228

2024

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Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes

Diabetes (New York, N.Y.), 2023-02, Vol.72 (2), p.299-308

2023

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Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

Human mutation, 2009-11, Vol.30 (11), p.1512-1526

2009

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Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance

The Journal of clinical investigation, 2007-01, Vol.117 (1), p.246-257

2007

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Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein–Ligand Residence Times

Journal of medicinal chemistry, 2016-08, Vol.59 (15), p.7167-7176

2016

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Integration of proteomics and metabolomics reveals energy and metabolic alterations induced by glucokinase (GCK) partial inactivation in hepatocytes

Cellular signalling, 2024-02, Vol.114, p.111009-111009, Article 111009

2024

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Polymerization in the actin ATPase clan regulates hexokinase activity in yeast

Science (American Association for the Advancement of Science), 2020-02, Vol.367 (6481), p.1039-1042

2020

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Tetrahydropalmatine from medicinal plants activates human glucokinase to regulate glucose homeostasis

Biotechnology and applied biochemistry, 2024-04, Vol.71 (2), p.295-313

2024

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Functional characterization of MODY2 mutations in the nuclear export signal of glucokinase

Biochimica et biophysica acta. Molecular basis of disease, 2018-07, Vol.1864 (7), p.2385-2394

2018

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α-cell glucokinase suppresses glucose-regulated glucagon secretion

Nature communications, 2018-02, Vol.9 (1), p.546-9, Article 546

2018

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Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants

Biochemical pharmacology, 2024-11, Vol.229, p.116499, Article 116499

2024

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Crystal structure of ADP‐dependent glucokinase from Methanocaldococcus jannaschii in complex with 5‐iodotubercidin reveals phosphoryl transfer mechanism

Protein science, 2018-03, Vol.27 (3), p.790-797

2018

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A comprehensive map of human glucokinase variant activity

Genome Biology, 2023-04, Vol.24 (1), p.97-23, Article 97

2023

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β-Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control

Journal of diabetes, 2023-05, Vol.15 (5), p.409-418

2023

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Molecular and cellular regulation of human glucokinase

Hormonal and Metabolite Regulation of Hepatic Glucokinase

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Characterizing glucokinase variant mechanisms using a multiplexed abundance assay

Mutational analysis of allosteric activation and inhibition of glucokinase

Glucokinase activity in diabetes: too much of a good thing?

Elucidating the Glucokinase Activating Potentials of Naturally Occurring Prenylated Flavonoids: An Explicit Computational Approach

Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes

Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice

Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice

Liver glucokinase: An overview on the regulatorymechanisms of its activity

Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study

Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance

Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein–Ligand Residence Times

Integration of proteomics and metabolomics reveals energy and metabolic alterations induced by glucokinase (GCK) partial inactivation in hepatocytes

Polymerization in the actin ATPase clan regulates hexokinase activity in yeast

Tetrahydropalmatine from medicinal plants activates human glucokinase to regulate glucose homeostasis

Functional characterization of MODY2 mutations in the nuclear export signal of glucokinase

α-cell glucokinase suppresses glucose-regulated glucagon secretion

Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants

Crystal structure of ADP‐dependent glucokinase from Methanocaldococcus jannaschii in complex with 5‐iodotubercidin reveals phosphoryl transfer mechanism

A comprehensive map of human glucokinase variant activity

β-Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control

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