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Mechanistic Modeling to Predict the Transporter- and Enzyme-Mediated Drug-Drug Interactions of Repaglinide

Pharmaceutical research, 2013-04, Vol.30 (4), p.1188-1199

2013

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Mass changes in remnant cholesterol and LDL cholesterol explain part of the results of gemfibrozil and non-gemfibrozil fibrate trials

Journal of internal medicine, 2024-05, Vol.295 (5), p.707-710

2024

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Gemfibrozil derivatives as activators of soluble guanylyl cyclase – A structure-activity study

European journal of medicinal chemistry, 2021-11, Vol.224, p.113729-113729, Article 113729

2021

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Establishment and characterization of a mouse model of rhabdomyolysis by coadministration of statin and fibrate

Toxicology letters, 2019-06, Vol.307, p.49-58

2019

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Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters

Expert opinion on drug metabolism & toxicology, 2017-01, Vol.13 (1), p.83-95

2017

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Gemfibrozil palliates adriamycin-induced testicular injury in male rats via modulating oxidative, endocrine and inflammatory changes in rats

Tissue & cell, 2023-06, Vol.82, p.102037-102037, Article 102037

2023

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Benzylic Oxidation of Gemfibrozil-1-O-β-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition

Chemical research in toxicology, 2009-07, Vol.22 (7), p.1298-1309

2009

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Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance

International Journal of Obesity, 2018-03, Vol.42 (3), p.391-397

2018

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Parental gemfibrozil exposure impacts zebrafish F1 offspring, but not subsequent generations

Aquatic toxicology, 2019-07, Vol.212, p.194-204

2019

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Gemfibrozil, a lipid‐lowering drug, improves hepatorenal damages in a mouse model of aging

Fundamental & clinical pharmacology, 2023-06, Vol.37 (3), p.599-605

2023

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Gemfibrozil Alleviates Cognitive Impairment by Inhibiting Ferroptosis of Astrocytes via Restoring the Iron Metabolism and Promoting Antioxidant Capacity in Type 2 Diabetes

Molecular neurobiology, 2024-02, Vol.61 (2), p.1187-1201

2024

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The Preparation and Application of Diaryliodonium Salts Derived from Gemfibrozil and Gemfibrozil Methyl Ester

Synthesis (Stuttgart), 2022-03, Vol.54 (5), p.1388-1394

2022

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Effects and bioaccumulation of gold nanoparticles in the gilthead seabream (Sparus aurata) – Single and combined exposures with gemfibrozil

Chemosphere (Oxford), 2019-01, Vol.215, p.248-260

2019

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Biodegradation of emerging organic pollutant gemfibrozil: Mechanism, kinetics and pathway modelling

Bioresource technology, 2023-04, Vol.374, p.128749-128749, Article 128749

2023

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Evaluation of Anti-aging Effects of Gemfibrozil on D-galactose induced Aging Mouse Model

INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY, 2023-09, Vol.13 (3)

2023

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Dose-dependent interaction between gemfibrozil and repaglinide in humans: strong inhibition of CYP2C8 with subtherapeutic gemfibrozil doses

Drug metabolism and disposition, 2011-10, Vol.39 (10), p.1977-1986

2011

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Effects of gemfibrozil on the growth, reproduction, and energy stores of Daphnia magna in the presence of varying food concentrations

Chemosphere (Oxford), 2018-02, Vol.192, p.75-80

2018

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Fibrates for primary prevention of cardiovascular disease events

Cochrane database of systematic reviews, 2016-11, Vol.11 (3), p.CD009753

2016

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Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms

CNS neuroscience & therapeutics, 2024-03, Vol.30 (3), p.e14473-n/a

2024

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Gemfibrozil Pretreatment Affecting Antioxidant Defense System and Inflammatory, but not Nrf-2 Signaling Pathways Resulted in Female Neuroprotection and Male Neurotoxicity in the Rat Models of Global Cerebral Ischemia–Reperfusion

Neurotoxicity research, 2013-04, Vol.23 (3), p.225-237

2013

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Magnetic solid phase extraction of gemfibrozil from human serum and pharmaceutical wastewater samples utilizing a β-cyclodextrin grafted graphene oxide-magnetite nano-hybrid

Talanta (Oxford), 2015-03, Vol.134, p.387-393

2015

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Gemfibrozil greatly increases plasma concentrations of cerivastatin

Clinical pharmacology and therapeutics, 2002-12, Vol.72 (6), p.685-691

2002

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Synthesis, characterization and in vitro hydrolysis of a gemfibrozil-nicotinic acid codrug for improvement of lipid profile

European journal of pharmaceutical sciences, 2011-06, Vol.43 (3), p.99-108

2011

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Gemfibrozil, food and drug administration‐approved lipid‐lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis

Journal of neurochemistry, 2017-05, Vol.141 (3), p.423-435

2017

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Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

International journal of pharmaceutics, 2012-07, Vol.431 (1-2), p.161-175

2012

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Mechanistic Modeling to Predict the Transporter- and Enzyme-Mediated Drug-Drug Interactions of Repaglinide

Mass changes in remnant cholesterol and LDL cholesterol explain part of the results of gemfibrozil and non-gemfibrozil fibrate trials

Gemfibrozil derivatives as activators of soluble guanylyl cyclase – A structure-activity study

Establishment and characterization of a mouse model of rhabdomyolysis by coadministration of statin and fibrate

Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters

Gemfibrozil palliates adriamycin-induced testicular injury in male rats via modulating oxidative, endocrine and inflammatory changes in rats

Benzylic Oxidation of Gemfibrozil-1-O-β-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition

Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance

Parental gemfibrozil exposure impacts zebrafish F1 offspring, but not subsequent generations

Gemfibrozil, a lipid‐lowering drug, improves hepatorenal damages in a mouse model of aging

Gemfibrozil Alleviates Cognitive Impairment by Inhibiting Ferroptosis of Astrocytes via Restoring the Iron Metabolism and Promoting Antioxidant Capacity in Type 2 Diabetes

The Preparation and Application of Diaryliodonium Salts Derived from Gemfibrozil and Gemfibrozil Methyl Ester

Effects and bioaccumulation of gold nanoparticles in the gilthead seabream (Sparus aurata) – Single and combined exposures with gemfibrozil

Biodegradation of emerging organic pollutant gemfibrozil: Mechanism, kinetics and pathway modelling

Evaluation of Anti-aging Effects of Gemfibrozil on D-galactose induced Aging Mouse Model

Dose-dependent interaction between gemfibrozil and repaglinide in humans: strong inhibition of CYP2C8 with subtherapeutic gemfibrozil doses

Effects of gemfibrozil on the growth, reproduction, and energy stores of Daphnia magna in the presence of varying food concentrations

Fibrates for primary prevention of cardiovascular disease events

Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms

Gemfibrozil Pretreatment Affecting Antioxidant Defense System and Inflammatory, but not Nrf-2 Signaling Pathways Resulted in Female Neuroprotection and Male Neurotoxicity in the Rat Models of Global Cerebral Ischemia–Reperfusion

Magnetic solid phase extraction of gemfibrozil from human serum and pharmaceutical wastewater samples utilizing a β-cyclodextrin grafted graphene oxide-magnetite nano-hybrid

Gemfibrozil greatly increases plasma concentrations of cerivastatin

Synthesis, characterization and in vitro hydrolysis of a gemfibrozil-nicotinic acid codrug for improvement of lipid profile

Gemfibrozil, food and drug administration‐approved lipid‐lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

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