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Targeting cell cycle regulation via the G2-M checkpoint for synthetic lethality in melanoma

Cell cycle (Georgetown, Tex.), 2021-06, Vol.20 (11), p.1041-1051

2021

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Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair

Nucleic acids research, 2021-11, Vol.49 (19), p.11067-11082

2021

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Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability

Molecular cell, 2018-08, Vol.71 (4), p.487-497.e3

2018

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PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance

Nature communications, 2020-08, Vol.11 (1), p.4053-4053, Article 4053

2020

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Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest

PloS one, 2017-07, Vol.12 (7), p.e0181081-e0181081

2017

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USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma

Nature communications, 2022-01, Vol.13 (1), p.501-501, Article 501

2022

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Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint

Genes & development, 2012-05, Vol.26 (10), p.1028-1040

2012

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The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes

Nucleic acids research, 2016-01, Vol.44 (1), p.164

2016

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The rDNA is biomolecular condensate formed by polymer-polymer phase separation and is sequestered in the nucleolus by transcription and R-loops

Nucleic acids research, 2021-05, Vol.49 (8), p.4586-4598

2021

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Mild replication stress causes chromosome mis-segregation via premature centriole disengagement

Nature communications, 2019-08, Vol.10 (1), p.3585-14, Article 3585

2019

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DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress

The Journal of cell biology, 2017-10, Vol.216 (10), p.3097-3115

2017

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ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury

Cell death & disease, 2019-03, Vol.10 (4), p.253-253, Article 253

2019

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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

PLoS genetics, 2012-07, Vol.8 (7), p.e1002772-e1002772

2012

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Resveratrol targets TyrRS acetylation to protect against radiation‐induced damage

The FASEB journal, 2019-07, Vol.33 (7), p.8083-8093

2019

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MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression

BMC cancer, 2018-02, Vol.18 (1), p.200-200, Article 200

2018

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Assembly of a parts list of the human mitotic cell cycle machinery

Journal of molecular cell biology, 2019-08, Vol.11 (8), p.703-718

2019

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UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination

The Journal of cell biology, 2023-11, Vol.222 (11)

2023

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ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

PloS one, 2019-01, Vol.14 (1), p.e0209224-e0209224

2019

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DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells

Biochemical and biophysical research communications, 2020-07, Vol.528 (3), p.586-593

2020

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Defective Cyclin B1 Induction in Trastuzumab-emtansine (T-DM1) Acquired Resistance in HER2-positive Breast Cancer

Clinical cancer research, 2017-11, Vol.23 (22), p.7006-7019

2017

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SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway

British journal of cancer, 2017-10, Vol.117 (8), p.1139-1153

2017

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Decoupling dedifferentiation and G2/M arrest in kidney fibrosis

The Journal of clinical investigation, 2022-12, Vol.132 (23)

Humphreys, Benjamin D

2022

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Long non‐coding RNA FTH1P3 activates paclitaxel resistance in breast cancer through miR‐206/ABCB1

Journal of cellular and molecular medicine, 2018-09, Vol.22 (9), p.4068-4075

2018

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The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1

Cell cycle (Georgetown, Tex.), 2019-01, Vol.18 (1), p.16-33

2019

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Diallyl Disulfide Induces Apoptosis and Autophagy in Human Osteosarcoma MG-63 Cells through the PI3K/Akt/mTOR Pathway

Molecules (Basel, Switzerland), 2019-07, Vol.24 (14), p.2665

2019

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Targeting cell cycle regulation via the G2-M checkpoint for synthetic lethality in melanoma

Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair

Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability

PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance

Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest

USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint

The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes

The rDNA is biomolecular condensate formed by polymer-polymer phase separation and is sequestered in the nucleolus by transcription and R-loops

Mild replication stress causes chromosome mis-segregation via premature centriole disengagement

DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress

ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

Resveratrol targets TyrRS acetylation to protect against radiation‐induced damage

MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression

Assembly of a parts list of the human mitotic cell cycle machinery

UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination

ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells

Defective Cyclin B1 Induction in Trastuzumab-emtansine (T-DM1) Acquired Resistance in HER2-positive Breast Cancer

SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway

Decoupling dedifferentiation and G2/M arrest in kidney fibrosis

Long non‐coding RNA FTH1P3 activates paclitaxel resistance in breast cancer through miR‐206/ABCB1

The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1

Diallyl Disulfide Induces Apoptosis and Autophagy in Human Osteosarcoma MG-63 Cells through the PI3K/Akt/mTOR Pathway

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