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A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Molecular cell, 2020-05, Vol.78 (4), p.779-784.e5

2020

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Synergistic effects of common schizophrenia risk variants

Nature genetics, 2019-10, Vol.51 (10), p.1475-1485

2019

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Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells

Journal of virology, 2018-10, Vol.92 (19)

2018

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Colorimetric detection of furin based on enhanced catalytic activity of G-quadruplex/hemin DNAzyme

Analytica chimica acta, 2024-09, Vol.1323, p.343070, Article 343070

2024

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Cell entry mechanisms of SARS-CoV-2

Proceedings of the National Academy of Sciences - PNAS, 2020-05, Vol.117 (21), p.11727-11734

2020

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FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice

Arteriosclerosis, thrombosis, and vascular biology, 2019-03, Vol.39 (3), p.387-401

2019

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SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

Journal of general virology, 2020-11, Vol.101 (11), p.1156-1169

2020

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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Antiviral research, 2020-04, Vol.176, p.104742-104742, Article 104742

2020

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SARS-CoV-2 requires acidic pH to infect cells

Proceedings of the National Academy of Sciences - PNAS, 2022-09, Vol.119 (38), p.e2209514119

2022

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Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways

Nature communications, 2022-10, Vol.13 (1), p.6100-6100, Article 6100

2022

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A Golgi-Targeting and Dual-Color “Turn-On” Probe for Spatially Precise Imaging of Furin

Analytical chemistry (Washington), 2021-01, Vol.93 (3), p.1636-1642

2021

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Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway

Digestive and liver disease, 2021-10, Vol.53 (10), p.1276-1285

2021

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The genetic structure of SARS-CoV-2 does not rule out a laboratory origin: SARS-COV-2 chimeric structure and furin cleavage site might be the result of genetic manipulation

BioEssays, 2021-03, Vol.43 (3), p.e2000240

2021

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Loss of furin site enhances SARS-CoV-2 spike protein pseudovirus infection

Gene, 2023-03, Vol.856, p.147144-147144, Article 147144

2023

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FURIN regulates cytotoxic T‐lymphocyte effector function and memory cell transition in mice

European journal of immunology, 2023-06, Vol.53 (6), p.e2250246-n/a

2023

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Neuropilin-1 is a host factor for SARS-CoV-2 infection

Science (American Association for the Advancement of Science), 2020-11, Vol.370 (6518), p.861-865

2020

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Structure of Furin Protease Binding to SARS-CoV‑2 Spike Glycoprotein and Implications for Potential Targets and Virulence

The journal of physical chemistry letters, 2020-08, Vol.11 (16), p.6655-6663

Vankadari, Naveen

2020

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The proprotein convertase furin in cancer: more than an oncogene

Oncogene, 2022-02, Vol.41 (9), p.1252-1262

2022

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Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases

Journal of virology, 2022-03, Vol.96 (5), p.e0218621

2022

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Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein

Scientific reports, 2018-11, Vol.8 (1), p.16597-11, Article 16597

2018

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ACE2, TMPRSS2, and Furin variants and SARS‐CoV‐2 infection in Madrid, Spain

Journal of medical virology, 2021-02, Vol.93 (2), p.863-869

2021

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Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Nature (London), 2020-12, Vol.588 (7837), p.327-330

2020

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Roles of the polybasic furin cleavage site of spike protein in SARS‐CoV‐2 replication, pathogenesis, and host immune responses and vaccination

Journal of medical virology, 2022-05, Vol.94 (5), p.1815-1820

2022

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Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects

Cell reports (Cambridge), 2020-10, Vol.33 (2), p.108254-108254, Article 108254

2020

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A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Synergistic effects of common schizophrenia risk variants

Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells

Colorimetric detection of furin based on enhanced catalytic activity of G-quadruplex/hemin DNAzyme

Cell entry mechanisms of SARS-CoV-2

FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

SARS-CoV-2 requires acidic pH to infect cells

Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways

A Golgi-Targeting and Dual-Color “Turn-On” Probe for Spatially Precise Imaging of Furin

Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway

The genetic structure of SARS-CoV-2 does not rule out a laboratory origin: SARS-COV-2 chimeric structure and furin cleavage site might be the result of genetic manipulation

Loss of furin site enhances SARS-CoV-2 spike protein pseudovirus infection

FURIN regulates cytotoxic T‐lymphocyte effector function and memory cell transition in mice

Neuropilin-1 is a host factor for SARS-CoV-2 infection

Structure of Furin Protease Binding to SARS-CoV‑2 Spike Glycoprotein and Implications for Potential Targets and Virulence

The proprotein convertase furin in cancer: more than an oncogene

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases

Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein

ACE2, TMPRSS2, and Furin variants and SARS‐CoV‐2 infection in Madrid, Spain

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Roles of the polybasic furin cleavage site of spike protein in SARS‐CoV‐2 replication, pathogenesis, and host immune responses and vaccination

Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

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