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Biochemical properties and crystal structure of formate-tetrahydrofolate ligase from Methylobacterium extorquens CM4

Biochemical and biophysical research communications, 2020-07, Vol.528 (3), p.426-431

2020

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Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (12), p.E2319-E2326

2017

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Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development

The American journal of clinical nutrition, 2016-11, Vol.104 (5), p.1459-1469

2016

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Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects

The Journal of nutrition, 2018-04, Vol.148 (4), p.501-509

2018

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A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development

Human molecular genetics, 2013-09, Vol.22 (18), p.3705-3719

2013

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MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects

Human mutation, 2009-02, Vol.30 (2), p.212-220

2009

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SIGN EPISTASIS LIMITS EVOLUTIONARY TRADE-OFFS AT THE CONFLUENCE OF SINGLE- AND MULTI-CARBON METABOLISM IN METHYLOBACTERIUM EXTORQUENS AM1

Evolution, 2014-03, Vol.68 (3), p.760-771

2014

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An NTD-Associated Polymorphism in the 3′ UTR of MTHFD1L can Affect Disease Risk by Altering miRNA Binding

Human mutation, 2014-01, Vol.35 (1), p.96-104

2014

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Detection of active, potentially acetate-oxidizing syntrophs in an anaerobic digester by flux measurement and formyltetrahydrofolate synthetase (FTHFS) expression profiling

Microbiology (Society for General Microbiology), 2011-07, Vol.157 (Pt 7), p.1980-1989

2011

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Response to boguslaw stec's letter to the editor of protein science

Protein science, 2013-06, Vol.22 (6), p.675-676

2013

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Physiological role of FolD (methylenetetrahydrofolate dehydrogenase), FchA (methenyltetrahydrofolate cyclohydrolase) and Fhs (formyltetrahydrofolate synthetase) from Clostridium perfringens in a heterologous model of Escherichia coli

Microbiology (Society for General Microbiology), 2016-01, Vol.162 (1), p.145-155

2016

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Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma

The Journal of clinical investigation, 2017-05, Vol.127 (5), p.1856-1872

2017

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Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice

The American journal of clinical nutrition, 2012-04, Vol.95 (4), p.882-891

2012

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Time passes yet errors remain: Comments on the structure of N10‐formyltetrahydrofolate synthetase

Protein science, 2013-06, Vol.22 (6), p.671-674

Stec, Boguslaw

2013

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Mechanism of N10‐formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors

Protein science, 2012-02, Vol.21 (2), p.219-228

2012

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Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the Mthfd1l murine mutant

Development (Cambridge), 2024-05, Vol.151 (10)

2024

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Formate‐tetrahydrofolate ligase: supplying the cytosolic one‐carbon network in roots with one‐carbon units originating from glycolate

The Plant journal : for cell and molecular biology, 2024-09, Vol.119 (5), p.2464-2483

2024

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Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis

Journal of pineal research, 2021-12, Vol.71 (4), p.e12767-n/a

2021

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Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (2), p.549-554

2013

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Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy

Proceedings of the National Academy of Sciences - PNAS, 2021-09, Vol.118 (39), p.1

2021

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Deletion of the neural tube defect–associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos

The Journal of biological chemistry, 2018-04, Vol.293 (16), p.5821-5833

2018

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Investigation of the diversity of homoacetogenic bacteria in mesophilic and thermophilic anaerobic sludges using the formyltetrahydrofolate synthetase gene

Water science and technology, 2008-01, Vol.57 (5), p.675-680

2008

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Assimilation of formic acid and CO 2 by engineered Escherichia coli equipped with reconstructed one-carbon assimilation pathways

Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (40), p.E9271

2018

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The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma

Scandinavian journal of gastroenterology, 2018-05, Vol.53 (5), p.533-540

2018

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Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos

The Journal of biological chemistry, 2010-02, Vol.285 (7), p.4612-4620

2010

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Biochemical properties and crystal structure of formate-tetrahydrofolate ligase from Methylobacterium extorquens CM4

Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis

Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development

Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects

A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development

MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects

SIGN EPISTASIS LIMITS EVOLUTIONARY TRADE-OFFS AT THE CONFLUENCE OF SINGLE- AND MULTI-CARBON METABOLISM IN METHYLOBACTERIUM EXTORQUENS AM1

An NTD-Associated Polymorphism in the 3′ UTR of MTHFD1L can Affect Disease Risk by Altering miRNA Binding

Detection of active, potentially acetate-oxidizing syntrophs in an anaerobic digester by flux measurement and formyltetrahydrofolate synthetase (FTHFS) expression profiling

Response to boguslaw stec's letter to the editor of protein science

Physiological role of FolD (methylenetetrahydrofolate dehydrogenase), FchA (methenyltetrahydrofolate cyclohydrolase) and Fhs (formyltetrahydrofolate synthetase) from Clostridium perfringens in a heterologous model of Escherichia coli

Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma

Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice

Time passes yet errors remain: Comments on the structure of N10‐formyltetrahydrofolate synthetase

Mechanism of N10‐formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors

Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the Mthfd1l murine mutant

Formate‐tetrahydrofolate ligase: supplying the cytosolic one‐carbon network in roots with one‐carbon units originating from glycolate

Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis

Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice

Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy

Deletion of the neural tube defect–associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos

Investigation of the diversity of homoacetogenic bacteria in mesophilic and thermophilic anaerobic sludges using the formyltetrahydrofolate synthetase gene

Assimilation of formic acid and CO 2 by engineered Escherichia coli equipped with reconstructed one-carbon assimilation pathways

The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma

Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos

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