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A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer

The FEBS journal, 2011-12, Vol.278 (23), p.4683-4700

2011

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Engineered Anti‐GPC3 Immunotoxin, HN3‐ABD‐T20, Produces Regression in Mouse Liver Cancer Xenografts Through Prolonged Serum Retention

Hepatology (Baltimore, Md.), 2020-05, Vol.71 (5), p.1696-1711

2020

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Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

Nature (London), 2022-02, Vol.602 (7897), p.496-502

2022

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Removing T-cell epitopes with computational protein design

Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (23), p.8577-8582

2014

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The bicomponent pore-forming leucocidins of Staphylococcus aureus

Microbiology and molecular biology reviews, 2014-06, Vol.78 (2), p.199-230

2014

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Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation

Frontiers in immunology, 2020-06, Vol.11, p.1261

2020

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Human single-chain antibodies that neutralize Pseudomonas aeruginosa-exotoxin A-mediated cellular apoptosis

Scientific reports, 2019-10, Vol.9 (1), p.14928-15, Article 14928

2019

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Pseudomonas Exotoxin A‑Based Immunotherapy Targeting CCK2R-Expressing Colorectal Malignancies: An In Vitro and In Vivo Evaluation

Molecular pharmaceutics, 2021-06, Vol.18 (6), p.2285-2297

2021

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Potent and specific fusion toxins consisting of a HER2‑binding, ABD‑derived affinity protein, fused to truncated versions of Pseudomonas exotoxin A

International journal of oncology, 2019-07, Vol.55 (1), p.309-319

2019

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Modular Conjugation of a Potent Anti-HER2 Immunotoxin Using Coassociating Peptides

Bioconjugate chemistry, 2020-10, Vol.31 (10), p.2421-2430

2020

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toxic shock syndrome

Encyclopædia Britannica Online, 2020

2020

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Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry

Journal of the American Chemical Society, 2020-06, Vol.142 (25), p.10899-10904

2020

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Correction for Gao et al., “Identification of the Regulon of AphB and Its Essential Roles in LuxR and Exotoxin Asp Expression in the Pathogen Vibrio alginolyticus ”

Journal of bacteriology, 2024-08, Vol.206 (8)

2024

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Assessment of the impact of manufacturing changes on the physicochemical properties of the recombinant vaccine carrier ExoProtein A

Vaccine, 2019-09, Vol.37 (38), p.5762-5769

2019

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Immunogenicity of therapeutic recombinant immunotoxins

Immunological reviews, 2016-03, Vol.270 (1), p.152-164

2016

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Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR

Molecular cancer therapeutics, 2017-05, Vol.16 (5), p.956-965

2017

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Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (10), p.4575-4582

2019

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Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis

Nature communications, 2015-03, Vol.6 (1), p.6536-6536, Article 6536

2015

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Soluble Cytoplasmic Expression and Purification of Immunotoxin HER2(scFv)-PE24B as a Maltose Binding Protein Fusion

International journal of molecular sciences, 2021-06, Vol.22 (12), p.6483

2021

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immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (32), p.11311-11316

2008

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Cytotoxic and apoptotic properties of a novel nano‐toxin formulation based on biologically synthesized silver nanoparticle loaded with recombinant truncated pseudomonas exotoxin A

Journal of cellular physiology, 2020-04, Vol.235 (4), p.3711-3720

2020

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Epidermal Growth Factor Based Targeted Toxin for the Treatment of Bladder Cancer

Anticancer research, 2021-08, Vol.41 (8), p.3741-3746

2021

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Isolation and characterizations of a novel recombinant scFv antibody against exotoxin A of Pseudomonas aeruginosa

BMC infectious diseases, 2021-03, Vol.21 (1), p.300-300, Article 300

2021

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Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (14), p.5742-5747

2011

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Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy

Journal of controlled release, 2024-03, Vol.367, p.167-183

2024

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A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer

Engineered Anti‐GPC3 Immunotoxin, HN3‐ABD‐T20, Produces Regression in Mouse Liver Cancer Xenografts Through Prolonged Serum Retention

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

Removing T-cell epitopes with computational protein design

The bicomponent pore-forming leucocidins of Staphylococcus aureus

Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation

Human single-chain antibodies that neutralize Pseudomonas aeruginosa-exotoxin A-mediated cellular apoptosis

Pseudomonas Exotoxin A‑Based Immunotherapy Targeting CCK2R-Expressing Colorectal Malignancies: An In Vitro and In Vivo Evaluation

Potent and specific fusion toxins consisting of a HER2‑binding, ABD‑derived affinity protein, fused to truncated versions of Pseudomonas exotoxin A

Modular Conjugation of a Potent Anti-HER2 Immunotoxin Using Coassociating Peptides

toxic shock syndrome

Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry

Correction for Gao et al., “Identification of the Regulon of AphB and Its Essential Roles in LuxR and Exotoxin Asp Expression in the Pathogen Vibrio alginolyticus ”

Assessment of the impact of manufacturing changes on the physicochemical properties of the recombinant vaccine carrier ExoProtein A

Immunogenicity of therapeutic recombinant immunotoxins

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR

Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis

Soluble Cytoplasmic Expression and Purification of Immunotoxin HER2(scFv)-PE24B as a Maltose Binding Protein Fusion

immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

Cytotoxic and apoptotic properties of a novel nano‐toxin formulation based on biologically synthesized silver nanoparticle loaded with recombinant truncated pseudomonas exotoxin A

Epidermal Growth Factor Based Targeted Toxin for the Treatment of Bladder Cancer

Isolation and characterizations of a novel recombinant scFv antibody against exotoxin A of Pseudomonas aeruginosa

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy

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