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Severe Acute Lung Injury Related to COVID‐19 Infection: A Review and the Possible Role for Escin

Journal of clinical pharmacology, 2020-07, Vol.60 (7), p.815-825

2020

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Virucidal, antiviral and immunomodulatory activities of β‐escin and Aesculus hippocastanum extract

Journal of pharmacy and pharmacology, 2018-11, Vol.70 (11), p.1561-1571

2018

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Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut)

Bioorganic & medicinal chemistry letters, 2017-07, Vol.27 (13), p.3019-3025

2017

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Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L . towards future medicine

Journal of basic and clinical physiology and pharmacology, 2020-09, Vol.31 (5)

2020

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Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage

Drug and chemical toxicology (New York, N.Y. 1978), 2022-05, Vol.45 (3), p.1180-1187

2022

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Molecular docking analyses of Escin as regards cyclophosphamide-induced cardiotoxicity: In vivo and in Silico studies

Toxicology and applied pharmacology, 2021-01, Vol.411, p.115386, Article 115386

2021

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Computational and experimental characterization of isomers of escin-induced renal cytotoxicity by inhibiting heat shock proteins

European journal of pharmacology, 2021-10, Vol.908, p.174372, Article 174372

2021

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Escin alleviates cerebral ischemia-induced intestinal pyroptosis via the GR-dependent p38 MAPK/NF-κB signaling and NLRP3 inflammasome activation

International immunopharmacology, 2024-09, Vol.138, p.112592, Article 112592

2024

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Escin inhibits angiogenesis by suppressing interleukin‑8 and vascular endothelial growth factor production by blocking nuclear factor‑κB activation in pancreatic cancer cell lines

Oncology reports, 2021-05, Vol.45 (5), Article 55

2021

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Topical hydrogels with escin β‐sitosterol phytosome and escin: Formulation development and in vivo assessment of antihyperalgesic activity

Drug development research, 2019-11, Vol.80 (7), p.921-932

2019

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Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

Nature communications, 2015-02, Vol.6 (1), p.6220-6220, Article 6220

2015

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Promoting the adsorption of saponins at the hydrophilic solid-aqueous solution interface by the coadsorption with cationic surfactants

Journal of colloid and interface science, 2024-01, Vol.654 (Pt B), p.1031-1039

2024

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Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat

Journal of ethnopharmacology, 2012-01, Vol.139 (1), p.201-206

2012

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β-Escin Effectively Modulates HUVECS Proliferation and Tube Formation

Molecules (Basel, Switzerland), 2018-01, Vol.23 (1), p.197

2018

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Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties

Drug design, development and therapy, 2019-01, Vol.13, p.3425-3437

Gallelli, Luca

2019

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Escin's Multifaceted Therapeutic Profile in Treatment and Post-Treatment of Various Cancers: A Comprehensive Review

Biomolecules (Basel, Switzerland), 2023-02, Vol.13 (2), p.315

2023

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Aescin and diosmin each alone or in low dose- combination ameliorate liver damage induced by carbon tetrachloride in rats

BMC research notes, 2020-05, Vol.13 (1), p.259-7, Article 259

2020

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Enhanced mitochondrial co-localization of β-escin micelle and pancreatic tumor accumulation relation

Journal of drug delivery science and technology, 2023-11, Vol.89, p.104994, Article 104994

2023

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Combined treatment with low dose prednisone and escin improves the anti-arthritic effect in experimental arthritis

International immunopharmacology, 2016-02, Vol.31, p.257-265

2016

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Escin ameliorates inflammation via inhibiting mechanical stretch and chemically induced Piezo1 activation in vascular endothelial cells

European journal of pharmacology, 2023-10, Vol.956, p.175951-175951, Article 175951

2023

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Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway

Acta pharmacologica Sinica, 2018-10, Vol.39 (10), p.1645-1660

2018

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Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study after oral administration

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010-04, Vol.878 (11), p.861-867

2010

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Self-assembly in escin-nonionic surfactant mixtures: From micelles to vesicles

Journal of colloid and interface science, 2022-11, Vol.626, p.305-313

2022

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The Biosurfactant β -Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers

Molecules (Basel, Switzerland), 2019-12, Vol.25 (1), p.117

2019

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β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma

World journal of gastroenterology : WJG, 2015-01, Vol.21 (4), p.1148-1157

2015

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Severe Acute Lung Injury Related to COVID‐19 Infection: A Review and the Possible Role for Escin

Virucidal, antiviral and immunomodulatory activities of β‐escin and Aesculus hippocastanum extract

Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut)

Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L . towards future medicine

Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage

Molecular docking analyses of Escin as regards cyclophosphamide-induced cardiotoxicity: In vivo and in Silico studies

Computational and experimental characterization of isomers of escin-induced renal cytotoxicity by inhibiting heat shock proteins

Escin alleviates cerebral ischemia-induced intestinal pyroptosis via the GR-dependent p38 MAPK/NF-κB signaling and NLRP3 inflammasome activation

Escin inhibits angiogenesis by suppressing interleukin‑8 and vascular endothelial growth factor production by blocking nuclear factor‑κB activation in pancreatic cancer cell lines

Topical hydrogels with escin β‐sitosterol phytosome and escin: Formulation development and in vivo assessment of antihyperalgesic activity

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

Promoting the adsorption of saponins at the hydrophilic solid-aqueous solution interface by the coadsorption with cationic surfactants

Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat

β-Escin Effectively Modulates HUVECS Proliferation and Tube Formation

Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties

Escin's Multifaceted Therapeutic Profile in Treatment and Post-Treatment of Various Cancers: A Comprehensive Review

Aescin and diosmin each alone or in low dose- combination ameliorate liver damage induced by carbon tetrachloride in rats

Enhanced mitochondrial co-localization of β-escin micelle and pancreatic tumor accumulation relation

Combined treatment with low dose prednisone and escin improves the anti-arthritic effect in experimental arthritis

Escin ameliorates inflammation via inhibiting mechanical stretch and chemically induced Piezo1 activation in vascular endothelial cells

Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway

Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study after oral administration

Self-assembly in escin-nonionic surfactant mixtures: From micelles to vesicles

The Biosurfactant β -Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers

β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma

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