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Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation

Cellular signalling, 2018-01, Vol.42, p.227-235

2018

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Intranasal LAG3 antibody infusion induces a rapid antidepressant effect via the hippocampal ERK1/2-BDNF signaling pathway in chronically stressed mice

Neuropharmacology, 2024-11, Vol.259, p.110118, Article 110118

2024

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SHU9119 and MBP10 are biased ligands at the human melanocortin-4 receptor

Biochemical pharmacology, 2024-05, p.116325-116325, Article 116325

2024

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Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy

Free radical biology & medicine, 2016-01, Vol.90, p.12-23

2016

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1,25-Dihydroxyvitamin D3 inhibits porcine epidemic diarrhea virus replication by regulating cell cycle resumption in IPEC-J2 porcine epithelial cells

Microbial pathogenesis, 2021-09, Vol.158, p.105017-105017, Article 105017

2021

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PPARβ/δ attenuates hepatic fibrosis by reducing SMAD3 phosphorylation and p300 levels via AMPK in hepatic stellate cells

Biomedicine & pharmacotherapy, 2024-10, Vol.179, p.117303, Article 117303

2024

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Efferocytosis induces macrophage proliferation to help resolve tissue injury

Cell metabolism, 2021-12, Vol.33 (12), p.2445-2463.e8

2021

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Activation of cannabinoid CB 2 receptor negatively regulates IL‐12p40 production in murine macrophages: role of IL‐10 and ERK1/2 kinase signaling

British journal of pharmacology, 2009-01, Vol.145 (4), p.441-448

2009

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Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis

Free radical biology & medicine, 2018-02, Vol.116, p.159-171

2018

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The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways

Tumor biology, 2015-11, Vol.36 (11), p.8379-8387

2015

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Integration of network pharmacology and experimental verification to reveal the active components and molecular mechanism of modified Danzhi Xiaoyao San in the treatment of depression

Journal of ethnopharmacology, 2025-01, Vol.336, p.118739, Article 118739

2025

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Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors

Pharmacological research, 2021-01, Vol.163, p.105336-105336, Article 105336

2021

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Unveiling the protective potential of mirabegron against thioacetamide-induced hepatic encephalopathy in rats: Insights into cAMP/PPAR-γ/p-ERK1/2/p S536 NF-κB p 65 and p-CREB/BDNF/TrkB in parallel with oxidative and apoptotic trajectories

Biochemical pharmacology, 2024-11, Vol.229, p.116504, Article 116504

2024

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Electroacupuncture Alleviates Dry Eye Ocular Pain Through TNF-ɑ Mediated ERK1/2/P2X3R Signaling Pathway in SD Rats

Journal of pain research, 2023-12, Vol.16, p.4241-4252

2023

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Hippocampal activation of 5‐HT1B receptors and BDNF production by vagus nerve stimulation in rats under chronic restraint stress

The European journal of neuroscience, 2019-07, Vol.50 (1), p.1820-1830

2019

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Quercetin potentiates insulin secretion and protects INS-1 pancreatic [beta]-cells against oxidative damage via the ERK1/2 pathway

British journal of pharmacology, 2010-10, Vol.161 (4), p.799

2010

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Current developments in extracellular-regulated protein kinase (ERK1/2) inhibitors

Drug discovery today, 2022-05, Vol.27 (5), p.1464-1473

2022

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Osteogenesis and angiogenesis induced by porous β-CaSiO3 /PDLGA composite scaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways

Biomaterials, 2013-01, Vol.34 (1), p.64-77

2013

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The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2

European journal of pharmacology, 2023-10, Vol.957, p.175969-175969, Article 175969

2023

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Nicotine Prevents Oxidative Stress-Induced Hippocampal Neuronal Injury Through α7-nAChR/Erk1/2 Signaling Pathway

Frontiers in molecular neuroscience, 2020-11, Vol.13, p.557647

2020

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On the G protein-coupling selectivity of the native A2B adenosine receptor

Biochemical pharmacology, 2018-05, Vol.151 (C), p.201-213

2018

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Novel analgesic peptide derived from Cinobufacini injection suppressing inflammation and pain via ERK1/2/COX-2 pathway

International immunopharmacology, 2024-11, Vol.141, p.112918, Article 112918

2024

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Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway

Journal of natural medicines, 2024-06, Vol.78 (3), p.474-487

2024

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The interplay between fibroblast‐like synovial and vascular endothelial cells leads to angiogenesis via the sphingosine‐1‐phosphate‐induced RhoA‐F‐Actin and Ras‐Erk1/2 pathways and the intervention of geniposide

Phytotherapy research, 2021-09, Vol.35 (9), p.5305-5317

2021

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Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways

Acta pharmacologica Sinica, 2019-05, Vol.40 (5), p.599-607

2019

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Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation

Intranasal LAG3 antibody infusion induces a rapid antidepressant effect via the hippocampal ERK1/2-BDNF signaling pathway in chronically stressed mice

SHU9119 and MBP10 are biased ligands at the human melanocortin-4 receptor

Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy

1,25-Dihydroxyvitamin D3 inhibits porcine epidemic diarrhea virus replication by regulating cell cycle resumption in IPEC-J2 porcine epithelial cells

PPARβ/δ attenuates hepatic fibrosis by reducing SMAD3 phosphorylation and p300 levels via AMPK in hepatic stellate cells

Efferocytosis induces macrophage proliferation to help resolve tissue injury

Activation of cannabinoid CB 2 receptor negatively regulates IL‐12p40 production in murine macrophages: role of IL‐10 and ERK1/2 kinase signaling

Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis

The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways

Integration of network pharmacology and experimental verification to reveal the active components and molecular mechanism of modified Danzhi Xiaoyao San in the treatment of depression

Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors

Unveiling the protective potential of mirabegron against thioacetamide-induced hepatic encephalopathy in rats: Insights into cAMP/PPAR-γ/p-ERK1/2/p S536 NF-κB p 65 and p-CREB/BDNF/TrkB in parallel with oxidative and apoptotic trajectories

Electroacupuncture Alleviates Dry Eye Ocular Pain Through TNF-ɑ Mediated ERK1/2/P2X3R Signaling Pathway in SD Rats

Hippocampal activation of 5‐HT1B receptors and BDNF production by vagus nerve stimulation in rats under chronic restraint stress

Quercetin potentiates insulin secretion and protects INS-1 pancreatic [beta]-cells against oxidative damage via the ERK1/2 pathway

Current developments in extracellular-regulated protein kinase (ERK1/2) inhibitors

Osteogenesis and angiogenesis induced by porous β-CaSiO3 /PDLGA composite scaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways

The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2

Nicotine Prevents Oxidative Stress-Induced Hippocampal Neuronal Injury Through α7-nAChR/Erk1/2 Signaling Pathway

On the G protein-coupling selectivity of the native A2B adenosine receptor

Novel analgesic peptide derived from Cinobufacini injection suppressing inflammation and pain via ERK1/2/COX-2 pathway

Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway

The interplay between fibroblast‐like synovial and vascular endothelial cells leads to angiogenesis via the sphingosine‐1‐phosphate‐induced RhoA‐F‐Actin and Ras‐Erk1/2 pathways and the intervention of geniposide

Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways

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