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Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer

Cancer research (Chicago, Ill.), 2017-10, Vol.77 (20), p.5564-5575

2017

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Inactivating mutations of acetyltransferase genes in B-cell lymphoma

Nature (London), 2011-03, Vol.471 (7337), p.189-195

2011

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Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth

Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (36), p.9701-9706

2017

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Decline of p300 contributes to cell senescence and growth inhibition of hUC-MSCs through p53/p21 signaling pathway

Biochemical and biophysical research communications, 2019-07, Vol.515 (1), p.24-30

2019

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EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer

BMC cancer, 2020-11, Vol.20 (1), p.1076-1076, Article 1076

2020

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Chemical Control of a CRISPR-Cas9 Acetyltransferase

ACS chemical biology, 2018-02, Vol.13 (2), p.455-460

2018

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Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300

The Journal of biological chemistry, 2016-03, Vol.291 (13), p.6714-6722

2016

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A Chemical Probe for Protein Crotonylation

Journal of the American Chemical Society, 2018-04, Vol.140 (14), p.4757-4760

2018

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Transgenic Mice Expressing an Inhibitory Truncated Form of p300 Exhibit Long-Term Memory Deficits

Learning & memory (Cold Spring Harbor, N.Y.), 2007-09, Vol.14 (9), p.564-572

2007

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Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

Nature chemical biology, 2019-05, Vol.15 (5), p.519

2019

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Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression

Cancer discovery, 2016-04, Vol.6 (4), p.430-445

2016

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A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb

Journal of the American Chemical Society, 2021-09, Vol.143 (37), p.15056-15062

2021

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Structural and Functional Impacts of ER Coactivator Sequential Recruitment

Molecular cell, 2017-09, Vol.67 (5), p.733-743.e4

2017

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Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition

Nature communications, 2024-04, Vol.15 (1), p.3483-3483

2024

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CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms

Cancer research (Chicago, Ill.), 2019-08, Vol.79 (15), p.3916-3927

2019

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Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal

Human molecular genetics, 2018-01, Vol.27 (1), p.190-198

2018

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The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway

Biochemical pharmacology, 2016-02, Vol.101, p.100-111

2016

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Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge

Proceedings of the National Academy of Sciences - PNAS, 2016-05, Vol.113 (21), p.E2993-E3001

2016

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Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer

European journal of medicinal chemistry, 2018-03, Vol.147, p.238-252

2018

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BMP2-activated Erk/MAP Kinase Stabilizes Runx2 by Increasing p300 Levels and Histone Acetyltransferase Activity

The Journal of biological chemistry, 2010-11, Vol.285 (47), p.36410-36419

2010

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Structural insights into TAZ2 domain–mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A

The Journal of biological chemistry, 2020-03, Vol.295 (13), p.4303-4315

2020

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MicroRNA‐224 is up‐regulated in hepatocellular carcinoma through epigenetic mechanisms

The FASEB journal, 2012-07, Vol.26 (7), p.3032-3041

2012

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Characterization of the p300 Taz2–p53 TAD2 Complex and Comparison with the p300 Taz2–p53 TAD1 Complex

Biochemistry (Easton), 2015-03, Vol.54 (11), p.2001-2010

2015

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Resveratrol inhibits matrix metalloproteinase-1 and -3 expression by suppressing of p300/NFκB acetylation in TNF-α-treated human dermal fibroblasts

Chemico-biological interactions, 2021-03, Vol.337, p.109395, Article 109395

2021

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Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth

Decline of p300 contributes to cell senescence and growth inhibition of hUC-MSCs through p53/p21 signaling pathway

EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer

Chemical Control of a CRISPR-Cas9 Acetyltransferase

Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300

A Chemical Probe for Protein Crotonylation

Transgenic Mice Expressing an Inhibitory Truncated Form of p300 Exhibit Long-Term Memory Deficits

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression

A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb

Structural and Functional Impacts of ER Coactivator Sequential Recruitment

Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition

CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms

Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway

Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge

Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer

BMP2-activated Erk/MAP Kinase Stabilizes Runx2 by Increasing p300 Levels and Histone Acetyltransferase Activity

Structural insights into TAZ2 domain–mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A

MicroRNA‐224 is up‐regulated in hepatocellular carcinoma through epigenetic mechanisms

Characterization of the p300 Taz2–p53 TAD2 Complex and Comparison with the p300 Taz2–p53 TAD1 Complex

Resveratrol inhibits matrix metalloproteinase-1 and -3 expression by suppressing of p300/NFκB acetylation in TNF-α-treated human dermal fibroblasts

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