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DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics

Circulation (New York, N.Y.), 2022-03, Vol.145 (11), p.829-846

2022

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Nuclear F-actin assembly on damaged chromatin is regulated by DYRK1A and Spir1 phosphorylation

Nucleic acids research, 2024-08, Vol.52 (15), p.8897-8912

2024

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Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity

European journal of medicinal chemistry, 2018-09, Vol.157, p.1005-1016

2018

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Loss of the DYRK1A Protein Kinase Results in the Reduction in Ribosomal Protein Gene Expression, Ribosome Mass and Reduced Translation

Biomolecules (Basel, Switzerland), 2024-01, Vol.14 (1), p.31

2024

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The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine

Acta crystallographica. Section D, Biological crystallography., 2015-05, Vol.71 (5), p.1207-1215

2015

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Splice Variants of the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 4 (DYRK4) Differ in Their Subcellular Localization and Catalytic Activity

The Journal of biological chemistry, 2011-02, Vol.286 (7), p.5494-5505

2011

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Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (32), p.8155-8160

2018

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DYRK1A and cognition: A lifelong relationship

Pharmacology & therapeutics (Oxford), 2019-02, Vol.194, p.199-221

2019

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Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II

Nature (London), 2018-06, Vol.558 (7709), p.318-323

2018

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Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.9791-9810

2018

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Lorecivivint, a Novel Intraarticular CDC‐like Kinase 2 and Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial

Arthritis & rheumatology (Hoboken, N.J.), 2020-10, Vol.72 (10), p.1694-1706

2020

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Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

Osteoarthritis and cartilage, 2019-09, Vol.27 (9), p.1347-1360

2019

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Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview

International journal of molecular sciences, 2021-06, Vol.22 (11), p.6047

2021

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DYRK1A inhibitors for disease therapy: Current status and perspectives

European journal of medicinal chemistry, 2022-02, Vol.229, p.114062, Article 114062

2022

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Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders

FEBS letters, 2023-10, Vol.597 (19), p.2375-2415

2023

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Emerging roles of DYRK2 in cancer

The Journal of biological chemistry, 2021-01, Vol.296, p.100233-100233, Article 100233

2021

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Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease

European journal of medicinal chemistry, 2021-10, Vol.222, p.113554, Article 113554

2021

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The C. elegans anaphase promoting complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis

Developmental biology, 2007-02, Vol.302 (2), p.438-447

2007

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Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (49), p.24881-24891

2019

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Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

Nature communications, 2015-10, Vol.6 (1), p.8372, Article 8372

2015

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GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

Science translational medicine, 2020-02, Vol.12 (530)

2020

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Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells

Cell metabolism, 2019-03, Vol.29 (3), p.638-652.e5

2019

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DYRK1A Inhibitors as Potential Therapeutics for β‑Cell Regeneration for Diabetes

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.2901-2922

2021

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Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

Diabetes (New York, N.Y.), 2016-06, Vol.65 (6), p.1660-1671

2016

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A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

Nature communications, 2021-10, Vol.12 (1), p.6151-16, Article 6151

2021

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DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics

Nuclear F-actin assembly on damaged chromatin is regulated by DYRK1A and Spir1 phosphorylation

Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity

Loss of the DYRK1A Protein Kinase Results in the Reduction in Ribosomal Protein Gene Expression, Ribosome Mass and Reduced Translation

The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine

Splice Variants of the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 4 (DYRK4) Differ in Their Subcellular Localization and Catalytic Activity

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

DYRK1A and cognition: A lifelong relationship

Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II

Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics

Lorecivivint, a Novel Intraarticular CDC‐like Kinase 2 and Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial

Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview

DYRK1A inhibitors for disease therapy: Current status and perspectives

Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders

Emerging roles of DYRK2 in cancer

Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease

The C. elegans anaphase promoting complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells

DYRK1A Inhibitors as Potential Therapeutics for β‑Cell Regeneration for Diabetes

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

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