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Cerebral metabolic pattern associated with progressive parkinsonism in non-human primates reveals early cortical hypometabolism

Neurobiology of disease, 2022-06, Vol.167, p.105669-105669, Article 105669

2022

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Molar activity of [18F]FP-(+)-DTBZ radiopharmaceutical: Determination and its effect on quantitative analysis of VMAT2 autoradiography

Journal of pharmaceutical and biomedical analysis, 2021-09, Vol.203, p.114212-114212, Article 114212

2021

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Cholinergic system correlates of postural control changes in Parkinson’s disease freezers

Brain (London, England : 1878), 2023-08, Vol.146 (8), p.3243-3257

2023

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Derivatization of dihydrotetrabenazine for technetium-99m labelling towards a radiotracer targeting vesicular monoamine transporter 2

Arabian journal of chemistry, 2023-04, Vol.16 (4), p.104572, Article 104572

2023

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Synthesis and analysis of dihydrotetrabenazine derivatives as novel vesicular monoamine transporter 2 inhibitors

European journal of medicinal chemistry, 2021-11, Vol.224, p.113718-113718, Article 113718

2021

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CYP2D6 Genotype in Relation to Liver Toxicity Due to Tetrabenazine in Iraqi Patients with Hyperkinetic Movement Disorders

Iraqi journal of pharmaceutical sciences, 2020-12, Vol.29 (2), p.8-16

2020

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Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: A longitudinal in-vivo study

Neurobiology of disease, 2015-05, Vol.77, p.165-172

2015

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(+)-9-Trifluoroethoxy-α-Dihydrotetrabenazine as a Highly Potent Vesicular Monoamine Transporter 2 Inhibitor for Tardive Dyskinesia

Frontiers in pharmacology, 2021-12, Vol.12, p.770377-770377

2021

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Decreased Vesicular Monoamine Transporter Type 2 Availability in the Striatum Following Chronic Cocaine Self-Administration in Nonhuman Primates

Biological psychiatry (1969), 2015-03, Vol.77 (5), p.488-492

2015

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Pharmacokinetic and Pharmacologic Characterization of the Dihydrotetrabenazine Isomers of Deutetrabenazine and Valbenazine

Clinical pharmacology in drug development, 2023-04, Vol.12 (4), p.447-456

2023

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9-Cyclopropylmethoxy-dihydrotetrabenazine and its stereoisomers as vesicular monoamine transporter-2 inhibitors

Future medicinal chemistry, 2022-07, Vol.14 (13), p.991-1003

2022

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Chronic Neuroleptic‐Induced Parkinsonism Examined With Positron Emission Tomography

Movement disorders, 2020-07, Vol.35 (7), p.1189-1198

2020

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Synthesis of (+)- and (−)-Tetrabenazine from the Resolution of α-Dihydrotetrabenazine

Synthetic communications, 2009-09, Vol.39 (20), p.3574-3585

2009

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In vitro binding affinity vs. in vivo site occupancy: A PET study of four diastereomers of dihydrotetrabenazine (DTBZ) in monkey brain

Nuclear medicine and biology, 2021-01, Vol.92, p.38-42

2021

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PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation

Brain (London, England : 1878), 2005-12, Vol.128 (12), p.2777-2785

2005

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Increased Vesicular Monoamine Transporter Binding during Early Abstinence In Human Methamphetamine Users: Is VMAT2 a Stable Dopamine Neuron Biomarker?

The Journal of neuroscience, 2008-09, Vol.28 (39), p.9850-9856

2008

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Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter

Journal of Neural Transmission, 2009-12, Vol.116 (12), p.1591-1599

2009

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PET Measurement of Cardiac and Nigrostriatal Denervation in Parkinsonian Syndromes

The Journal of nuclear medicine (1978), 2006-11, Vol.47 (11), p.1769-1777

2006

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Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors

European journal of medicinal chemistry, 2011-05, Vol.46 (5), p.1841-1848

2011

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Effect of age on markers for monoaminergic neurons of normal and MPTP-lesioned rhesus monkeys: A multi-tracer PET study

NeuroImage (Orlando, Fla.), 2006-03, Vol.30 (1), p.26-35

2006

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Development and Validation of Stability-Indicating UPLC Method for 9-Desmethyl-α-dihydrotetrabenazine

Chromatographia, 2017-10, Vol.80 (10), p.1589-1595

2017

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Method Development and Validation for Determination of p-Toluenesulfonoxypropyl-(+)-Dihydrotetrabenazine Enantiomeric Purity by HPLC on a Chiral Stationary Phase

Chromatographia, 2017-03, Vol.80 (3), p.483-488

2017

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[11C]DTBZ‐PET correlates of levodopa responses in asymmetric Parkinson’s disease

Brain (London, England : 1878), 2003-12, Vol.126 (12), p.2648-2655

2003

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VMAT2 binding is elevated in dopa-responsive dystonia: Visualizing empty vesicles by PET

Synapse (New York, N.Y.), 2003-07, Vol.49 (1), p.20-28

2003

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Pyrrolidine analogs of GZ-793A: Synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2)

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (11), p.3342-3345

2013

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Cerebral metabolic pattern associated with progressive parkinsonism in non-human primates reveals early cortical hypometabolism

Molar activity of [18F]FP-(+)-DTBZ radiopharmaceutical: Determination and its effect on quantitative analysis of VMAT2 autoradiography

Cholinergic system correlates of postural control changes in Parkinson’s disease freezers

Derivatization of dihydrotetrabenazine for technetium-99m labelling towards a radiotracer targeting vesicular monoamine transporter 2

Synthesis and analysis of dihydrotetrabenazine derivatives as novel vesicular monoamine transporter 2 inhibitors

CYP2D6 Genotype in Relation to Liver Toxicity Due to Tetrabenazine in Iraqi Patients with Hyperkinetic Movement Disorders

Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: A longitudinal in-vivo study

(+)-9-Trifluoroethoxy-α-Dihydrotetrabenazine as a Highly Potent Vesicular Monoamine Transporter 2 Inhibitor for Tardive Dyskinesia

Decreased Vesicular Monoamine Transporter Type 2 Availability in the Striatum Following Chronic Cocaine Self-Administration in Nonhuman Primates

Pharmacokinetic and Pharmacologic Characterization of the Dihydrotetrabenazine Isomers of Deutetrabenazine and Valbenazine

9-Cyclopropylmethoxy-dihydrotetrabenazine and its stereoisomers as vesicular monoamine transporter-2 inhibitors

Chronic Neuroleptic‐Induced Parkinsonism Examined With Positron Emission Tomography

Synthesis of (+)- and (−)-Tetrabenazine from the Resolution of α-Dihydrotetrabenazine

In vitro binding affinity vs. in vivo site occupancy: A PET study of four diastereomers of dihydrotetrabenazine (DTBZ) in monkey brain

PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation

Increased Vesicular Monoamine Transporter Binding during Early Abstinence In Human Methamphetamine Users: Is VMAT2 a Stable Dopamine Neuron Biomarker?

Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter

PET Measurement of Cardiac and Nigrostriatal Denervation in Parkinsonian Syndromes

Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors

Effect of age on markers for monoaminergic neurons of normal and MPTP-lesioned rhesus monkeys: A multi-tracer PET study

Development and Validation of Stability-Indicating UPLC Method for 9-Desmethyl-α-dihydrotetrabenazine

Method Development and Validation for Determination of p-Toluenesulfonoxypropyl-(+)-Dihydrotetrabenazine Enantiomeric Purity by HPLC on a Chiral Stationary Phase

[11C]DTBZ‐PET correlates of levodopa responses in asymmetric Parkinson’s disease

VMAT2 binding is elevated in dopa-responsive dystonia: Visualizing empty vesicles by PET

Pyrrolidine analogs of GZ-793A: Synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2)

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