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[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (15), p.4027-4032

2016

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Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer

Cell death & disease, 2024-02, Vol.15 (2), p.131-13, Article 131

2024

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Gemcitabine: a critical nucleoside for cancer therapy

Current medicinal chemistry, 2012-03, Vol.19 (7), p.1076-1087

2012

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Development and preclinical pharmacology of a novel dCK inhibitor, DI-87

Biochemical pharmacology, 2020-02, Vol.172, p.113742-113742, Article 113742

2020

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Down-regulation of Deoxycytidine Kinase Enhances Acquired Resistance to Gemcitabine in Pancreatic Cancer

Anticancer research, 2008-07, Vol.28 (4B), p.2205-2212

2008

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Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication

The Journal of experimental medicine, 2014-03, Vol.211 (3), p.473-486

2014

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Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability

Journal of medicinal chemistry, 2014-11, Vol.57 (22), p.9480-9494

2014

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Development of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission Tomography

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.6696-6708

2013

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The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death

International journal of molecular sciences, 2016-11, Vol.17 (11), p.1939-1939

2016

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Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma

Molecular cancer therapeutics, 2016-06, Vol.15 (6), p.1271-1278

2016

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Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules

Acta crystallographica. Section D, Biological crystallography., 2014-01, Vol.70 (1), p.68-78

2014

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Effective double whammy targets DNA synthesis in leukemia

The Journal of experimental medicine, 2014-03, Vol.211 (3), p.384-385

Chabner, Bruce A

2014

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Phosphorylation of deoxycytidine kinase on Ser-74: Impact on kinetic properties and nucleoside analog activation in cancer cells

Biochemical pharmacology, 2012-07, Vol.84 (1), p.43-51

2012

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In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients

British journal of cancer, 2006-08, Vol.95 (3), p.289-297

2006

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Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6784-6787

2009

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Is the resistance of gemcitabine for pancreatic cancer settled only by overexpression of deoxycytidine kinase?

Oncology reports, 2010-02, Vol.23 (2), p.471-475

2010

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Cytosine arabinoside affects multiple cellular factors and induces drug resistance in human lymphoid cells

Biochemical pharmacology, 2005-08, Vol.70 (3), p.426-432

2005

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Novel Potent Inhibitors of Deoxycytidine Kinase Identified and Compared by Multiple Assays

Journal of biomolecular screening, 2010-01, Vol.15 (1), p.72-79

2010

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5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6780-6783

2009

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Comparison of the Mechanism of Cytotoxicity of 2-Chloro-9-(2-deoxy-2-fluoro-Î²-d-arabinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-Î²-d-ribofuranosyl)adenine, and 2-Chloro-9-(2-deoxy-2,2-difluoro-Î²-d-ribofuranosyl)adenine in CEM Cells

Molecular pharmacology, 1999-03, Vol.55 (3), p.515-520

1999

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Purine analogues: rationale for development, mechanisms of action, and pharmacokinetics in hairy cell leukemia

Hematology/oncology clinics of North America, 2006-10, Vol.20 (5), p.1087-1097

2006

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Inhibition of Deoxynucleoside Kinases in Human Thymocytes Prevents dATP Accumulation and Induction of Apoptosis

Nucleosides, nucleotides & nucleic acids, 2008-06, Vol.27 (6-7), p.816-820

2008

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Inactivation of deoxycytidine kinase and overexpression of P-glycoprotein in AraC and daunorubicin double resistant leukemic cell lines

Leukemia research, 2003-05, Vol.27 (5), p.445-453

2003

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Nucleotide specificity of human deoxycytidine kinase

Molecular pharmacology, 1992-09, Vol.42 (3), p.518-524

1992

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Kinetic Analysis of Human Deoxycytidine Kinase with the True Phosphate Donor Uridine Triphosphate

Biochemistry (Easton), 1997-06, Vol.36 (24), p.7540-7547

1997

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[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity

Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer

Gemcitabine: a critical nucleoside for cancer therapy

Development and preclinical pharmacology of a novel dCK inhibitor, DI-87

Down-regulation of Deoxycytidine Kinase Enhances Acquired Resistance to Gemcitabine in Pancreatic Cancer

Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication

Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability

Development of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission Tomography

The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death

Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma

Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules

Effective double whammy targets DNA synthesis in leukemia

Phosphorylation of deoxycytidine kinase on Ser-74: Impact on kinetic properties and nucleoside analog activation in cancer cells

In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients

Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors

Is the resistance of gemcitabine for pancreatic cancer settled only by overexpression of deoxycytidine kinase?

Cytosine arabinoside affects multiple cellular factors and induces drug resistance in human lymphoid cells

Novel Potent Inhibitors of Deoxycytidine Kinase Identified and Compared by Multiple Assays

5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase

Comparison of the Mechanism of Cytotoxicity of 2-Chloro-9-(2-deoxy-2-fluoro-Î²-d-arabinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-Î²-d-ribofuranosyl)adenine, and 2-Chloro-9-(2-deoxy-2,2-difluoro-Î²-d-ribofuranosyl)adenine in CEM Cells

Purine analogues: rationale for development, mechanisms of action, and pharmacokinetics in hairy cell leukemia

Inhibition of Deoxynucleoside Kinases in Human Thymocytes Prevents dATP Accumulation and Induction of Apoptosis

Inactivation of deoxycytidine kinase and overexpression of P-glycoprotein in AraC and daunorubicin double resistant leukemic cell lines

Nucleotide specificity of human deoxycytidine kinase

Kinetic Analysis of Human Deoxycytidine Kinase with the True Phosphate Donor Uridine Triphosphate

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