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Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides

Biochemical journal, 2006-07, Vol.397 (1), p.203-211

2006

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The Race To Find Antivirals for Zika Virus

Antimicrobial agents and chemotherapy, 2017-06, Vol.61 (6)

2017

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Identification and characterization of new potent inhibitors of dengue virus NS5 proteinase from Andrographis paniculata supercritical extracts on in animal cell culture and in silico approaches

Journal of ethnopharmacology, 2021-03, Vol.267, p.113541, Article 113541

2021

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Immunodominant T-cell responses to dengue virus NS3 are associated with DHF

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (39), p.16922-16927

2010

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Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

Nature microbiology, 2017-05, Vol.2, p.17037

2017

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Novel dengue virus NS2B/NS3 protease inhibitors

Antimicrobial agents and chemotherapy, 2015-02, Vol.59 (2), p.1100-1109

2015

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Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

Molecules (Basel, Switzerland), 2017-03, Vol.22 (3), p.505

2017

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Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors

European journal of medicinal chemistry, 2021-11, Vol.224, p.113698-113698, Article 113698

2021

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Biochemistry and Medicinal Chemistry of the Dengue Virus Protease

Chemical reviews, 2014-11, Vol.114 (22), p.11348-11381

2014

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Development in the Inhibition of Dengue Proteases as Drug Targets

Current medicinal chemistry, 2024-01, Vol.31 (16), p.2195-2233

2024

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RNA Helicase A Is an Important Host Factor Involved in Dengue Virus Replication

Journal of virology, 2019-02, Vol.93 (4)

2019

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Evaluation of Sofosbuvir (β-D-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine) as an inhibitor of Dengue virus replication

Scientific reports, 2017-07, Vol.7 (1), p.6345-11, Article 6345

2017

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Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation

Journal of Virology, 2012-01, Vol.86 (1), p.438-446

2012

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Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

Journal of Virology, 2011-07, Vol.85 (13), p.6548-6556

2011

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Molecular basis for specific viral RNA recognition and 2′-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

Proceedings of the National Academy of Sciences - PNAS, 2015-12, Vol.112 (48), p.14834-14839

2015

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Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase

Antimicrobial Agents and Chemotherapy, 2013-04, Vol.57 (4), p.1902-1912

2013

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The Dengue virus protease NS2B3 cleaves cyclic GMP-AMP synthase to suppress cGAS activation

The Journal of biological chemistry, 2023-03, Vol.299 (3), p.102986-102986, Article 102986

2023

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Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

The Journal of biological chemistry, 2011-02, Vol.286 (8), p.6233-6240

2011

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Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling

PloS one, 2019-01, Vol.14 (1), p.e0210869-e0210869

2019

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Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: Inhibition kinetics and docking studies

Bioorganic & medicinal chemistry, 2015-02, Vol.23 (3), p.466-470

2015

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Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

Journal of Virology, 2013-05, Vol.87 (9), p.5291-5295

2013

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Exploiting the unique features of Zika and Dengue proteases for inhibitor design

Biochimie, 2019-11, Vol.166, p.132-141

2019

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A Non-Replicative Role of the 3′ Terminal Sequence of the Dengue Virus Genome in Membranous Replication Organelle Formation

Cell reports (Cambridge), 2020-07, Vol.32 (1), p.107859-107859, Article 107859

2020

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Synthesis, Structure–Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B–NS3 Protease

Journal of medicinal chemistry, 2021-03, Vol.64 (5), p.2777-2800

2021

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Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format

Biochemical and biophysical research communications, 2014-10, Vol.453 (3), p.539-544

2014

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Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides

The Race To Find Antivirals for Zika Virus

Identification and characterization of new potent inhibitors of dengue virus NS5 proteinase from Andrographis paniculata supercritical extracts on in animal cell culture and in silico approaches

Immunodominant T-cell responses to dengue virus NS3 are associated with DHF

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

Novel dengue virus NS2B/NS3 protease inhibitors

Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors

Biochemistry and Medicinal Chemistry of the Dengue Virus Protease

Development in the Inhibition of Dengue Proteases as Drug Targets

RNA Helicase A Is an Important Host Factor Involved in Dengue Virus Replication

Evaluation of Sofosbuvir (β-D-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine) as an inhibitor of Dengue virus replication

Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

Molecular basis for specific viral RNA recognition and 2′-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase

The Dengue virus protease NS2B3 cleaves cyclic GMP-AMP synthase to suppress cGAS activation

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling

Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: Inhibition kinetics and docking studies

Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

Exploiting the unique features of Zika and Dengue proteases for inhibitor design

A Non-Replicative Role of the 3′ Terminal Sequence of the Dengue Virus Genome in Membranous Replication Organelle Formation

Synthesis, Structure–Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B–NS3 Protease

Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format

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