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CRL4-DCAF1 Ubiquitin Ligase Dependent Functions of HIV Viral Protein R and Viral Protein X

Viruses, 2024-08, Vol.16 (8), p.1313

2024

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DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1

Cell reports (Cambridge), 2024-07, Vol.43 (7), p.114368, Article 114368

2024

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DCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway

Journal of experimental & clinical cancer research, 2024-05, Vol.43 (1), p.136-136, Article 136

2024

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Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field

ACS medicinal chemistry letters, 2023-07, Vol.14 (7), p.949-954

2023

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The CRL4 E3 ligase Mahjong/DCAF1 controls cell competition through the transcription factor Xrp1, independently of polarity genes

Development (Cambridge), 2022-11, Vol.149 (22)

2022

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DCAF1 inhibits the NF-κB pathway by targeting p65

Immunology letters, 2022-09, Vol.249, p.33-42

2022

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Identification of DCAF1 by Clinical Exome Sequencing and Methylation Analysis as a Candidate Gene for Autism and Intellectual Disability: A Case Report

Journal of personalized medicine, 2022-05, Vol.12 (6), p.886

2022

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Merlin functions as a critical regulator in Staphylococcus aureus‐induced osteomyelitis

Journal of cellular physiology, 2022-01, Vol.237 (1), p.815-823

2022

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The CRL4DCAF1 cullin‐RING ubiquitin ligase is activated following a switch in oligomerization state

The EMBO journal, 2021-11, Vol.40 (22), p.e108008-n/a

2021

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Ddb1-Cullin4-Associated-Factor 1 in Macrophages Restricts the Staphylococcus aureus -Induced Osteomyelitis

Journal of inflammation research, 2021-01, Vol.14, p.1667-1676

2021

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Mining for Candidate Genes Controlling Secondary Growth of the Carrot Storage Root

International journal of molecular sciences, 2020-06, Vol.21 (12), p.4263

2020

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A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis

Redox biology, 2020-05, Vol.32, p.101485, Article 101485

2020

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Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly

Journal of virology, 2017-05, Vol.91 (9)

2017

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Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1

Biochemical journal, 2015-06, Vol.468 (2), p.303-313

2015

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Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr

Virology (New York, N.Y.), 2015-03, Vol.477, p.10-17

2015

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Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx

Virology (New York, N.Y.), 2015-02, Vol.476, p.19-25

2015

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Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest

Virology journal, 2014-06, Vol.11 (1), p.108-108, Article 108

2014

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VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases

BMC molecular biology, 2013-09, Vol.14 (1), p.22-22

2013

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The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection

Virology (New York, N.Y.), 2013-09, Vol.444 (1), p.191-202

2013

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Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells

Retrovirology, 2012-11, Vol.9 (1), p.93-93, Article 93

2012

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HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection

Virology (New York, N.Y.), 2012-05, Vol.427 (1), p.67-75

2012

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Merlin, a multi-suppressor from cell membrane to the nucleus

FEBS letters, 2012-05, Vol.586 (10), p.1403-1408

2012

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Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1)

Cell cycle (Georgetown, Tex.), 2010-11, Vol.9 (22), p.4433-4436

2010

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The functions of the HIV1 protein Vpr and its action through the DCAF1·DDB1·Cullin4 ubiquitin ligase

Cytokine (Philadelphia, Pa.), 2010-07, Vol.51 (1), p.1-9

2010

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HIV1 Vpr Arrests the Cell Cycle by Recruiting DCAF1/VprBP, a Receptor of the Cul4-DDB1 Ubiquitin Ligase

Cell cycle (Georgetown, Tex.), 2007-01, Vol.6 (2), p.182-188

2007

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CRL4-DCAF1 Ubiquitin Ligase Dependent Functions of HIV Viral Protein R and Viral Protein X

DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1

DCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway

Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field

The CRL4 E3 ligase Mahjong/DCAF1 controls cell competition through the transcription factor Xrp1, independently of polarity genes

DCAF1 inhibits the NF-κB pathway by targeting p65

Identification of DCAF1 by Clinical Exome Sequencing and Methylation Analysis as a Candidate Gene for Autism and Intellectual Disability: A Case Report

Merlin functions as a critical regulator in Staphylococcus aureus‐induced osteomyelitis

The CRL4DCAF1 cullin‐RING ubiquitin ligase is activated following a switch in oligomerization state

Ddb1-Cullin4-Associated-Factor 1 in Macrophages Restricts the Staphylococcus aureus -Induced Osteomyelitis

Mining for Candidate Genes Controlling Secondary Growth of the Carrot Storage Root

A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis

Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly

Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1

Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr

Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx

Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest

VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases

The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection

Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells

HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection

Merlin, a multi-suppressor from cell membrane to the nucleus

Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1)

The functions of the HIV1 protein Vpr and its action through the DCAF1·DDB1·Cullin4 ubiquitin ligase

HIV1 Vpr Arrests the Cell Cycle by Recruiting DCAF1/VprBP, a Receptor of the Cul4-DDB1 Ubiquitin Ligase

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