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Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1217-1228

2016

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Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.92

2010

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Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

Biochemistry (Easton), 2018-02, Vol.57 (5), p.817-826

2018

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Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets

Antioxidants & redox signaling, 2021-06, Vol.34 (16), p.1280

2021

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Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

PloS one, 2015-07, Vol.10 (7), p.e0132992

2015

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Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

Drug metabolism and disposition, 2009-10, Vol.37 (10), p.2087

2009

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Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450

International journal of molecular sciences, 2018-12, Vol.19 (12), p.3914

2018

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Heterologous expression of high-activity cytochrome P450 in mammalian cells

Scientific reports, 2020-08, Vol.10 (1), p.14193, Article 14193

2020

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Evaluation of Mutual Drug–Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method

Basic & clinical pharmacology & toxicology, 2016-09, Vol.119 (3), p.284-290

2016

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Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P‐Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Clinical pharmacology and therapeutics, 2018-12, Vol.104 (6), p.1249-1259

2018

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Respiratory complexes III and IV can each bind two molecules of cytochrome c at low ionic strength

FEBS letters, 2015-02, Vol.589 (4), p.476-483

2015

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Structure of a bacterial cell surface decaheme electron conduit

Proceedings of the National Academy of Sciences - PNAS, 2011-06, Vol.108 (23), p.9384-9389

2011

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Differential expression of cytochrome P450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma

PloS one, 2014-04, Vol.9 (4), p.e93261-e93261

2014

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Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450s

PloS one, 2014-02, Vol.9 (2), p.e87058-e87058

2014

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The Potential for Pharmacokinetic Interactions Between Cannabis Products and Conventional Medications

Journal of clinical psychopharmacology, 2019-09, Vol.39 (5), p.462

2019

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Prediction of Cytochrome P450 Inhibition Using a Deep Learning Approach and Substructure Pattern Recognition

Journal of chemical information and modeling, 2024-04, Vol.64 (7), p.2528-2538

2024

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Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors

Journal of medicinal chemistry, 2017-08, Vol.60 (15), p.6678-6692

2017

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Pogostone inhibits the activity of CYP3A4, 2C9, and 2E1 in vitro

Pharmaceutical biology, 2021-01, Vol.59 (1), p.530-534

2021

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Synthesis, biological evaluation and docking studies of trans‐stilbene methylthio derivatives as cytochromes P450 family 1 inhibitors

Chemical biology & drug design, 2017-12, Vol.90 (6), p.1226-1236

2017

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Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone

Drug metabolism and disposition, 2015-02, Vol.43 (2), p.182-189

2015

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Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics

Nature communications, 2021-03, Vol.12 (1), p.1621-1621, Article 1621

2021

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In Silico Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family

BioMed research international, 2021, Vol.2021 (1), p.5574789-5574789

2021

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A Highly Selective Ratiometric Two-Photon Fluorescent Probe for Human Cytochrome P450 1A

Journal of the American Chemical Society, 2015-11, Vol.137 (45), p.14488-14495

2015

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Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity

The pharmacogenomics journal, 2020-04, Vol.20 (2), p.192-201

2020

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Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants

Angewandte Chemie (International ed.), 2020-07, Vol.59 (30), p.12499-12505

International ed. in English, 2020

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