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Leveraging Human Plasma‐Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil

Clinical pharmacology and therapeutics, 2022-02, Vol.111 (2), p.425-434

2022

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Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4

Current drug metabolism, 2008-05, Vol.9 (4), p.310-322

Zhou, Shu-Feng

2008

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Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drug-metabolizing enzymes in human hepatocyte culture

Drug metabolism and disposition, 2011-08, Vol.39 (8), p.1415-1422

2011

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Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro

British journal of clinical pharmacology, 2018-03, Vol.84 (3), p.510-519

2018

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Distinct Patterns of Dysregulated Expression of Enzymes Involved in Androgen Synthesis and Metabolism in Metastatic Prostate Cancer Tumors

Cancer research (Chicago, Ill.), 2012-12, Vol.72 (23), p.6142-6152

2012

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Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1390-1398

2016

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CYP induction-mediated drug interactions: in vitro assessment and clinical implications

Pharmaceutical research, 2006-06, Vol.23 (6), p.1089-1116

Lin, Jiunn H

2006

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CYP3A Activity and Expression in Nonalcoholic Fatty Liver Disease

Drug metabolism and disposition, 2015-10, Vol.43 (10), p.1484-1490

2015

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Evaluation of Endogenous Metabolic Markers of Hepatic CYP3A Activity Using Metabolic Profiling and Midazolam Clearance

Clinical pharmacology and therapeutics, 2013-11, Vol.94 (5), p.601-609

2013

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Intestinal Drug Transporter Expression and the Impact of Grapefruit Juice in Humans

Clinical pharmacology and therapeutics, 2007-03, Vol.81 (3), p.362-370

2007

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Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes

Scientific reports, 2016-06, Vol.6 (1), p.28178-28178, Article 28178

2016

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Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4

The Journal of biological chemistry, 2008-04, Vol.283 (15), p.9674-9680

2008

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Quantitative Prediction of CYP3A4 Induction: Impact of Measured, Free, and Intracellular Perpetrator Concentrations from Human Hepatocyte Induction Studies on Drug-Drug Interaction Predictions

Drug metabolism and disposition, 2017-06, Vol.45 (6), p.692-705

2017

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Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI)

Stem cell research & therapy, 2022-01, Vol.13 (1), p.6-12, Article 6

2022

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Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR

Toxicology letters, 2013-10, Vol.222 (2), p.180-188

2013

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Transcriptional regulation of CYP3A4 by nuclear receptors in human hepatocytes under hypoxia

Drug metabolism reviews, 2020-04, Vol.52 (2), p.225-234

2020

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Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

Clinical pharmacology and therapeutics, 2014-02, Vol.95 (2), p.179-188

2014

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Effects of atorvastatin metabolites on induction of drug‐metabolizing enzymes and membrane transporters through human pregnane X receptor

British journal of pharmacology, 2012-03, Vol.165 (5), p.1595-1608

2012

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Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG Cells

Drug metabolism and disposition, 2016-01, Vol.44 (1), p.50-60

2016

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Modeling, prediction, and in vitro in vivo correlation of CYP3A4 induction

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2355-2370

2008

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Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats

Journal of ethnopharmacology, 2014-03, Vol.152 (2), p.358-363

2014

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The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/−) and TP53(−/−) cells

Toxicology (Amsterdam), 2018-04, Vol.398-399, p.1-12

2018

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Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction

Drug metabolism and disposition, 2009-08, Vol.37 (8), p.1658-1666

2009

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Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes

PloS one, 2015-09, Vol.10 (9), p.e0137720

2015

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Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells

Scientific reports, 2016-06, Vol.6 (1), p.28116-28116, Article 28116

2016

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Leveraging Human Plasma‐Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil

Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4

Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drug-metabolizing enzymes in human hepatocyte culture

Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro

Distinct Patterns of Dysregulated Expression of Enzymes Involved in Androgen Synthesis and Metabolism in Metastatic Prostate Cancer Tumors

Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds

CYP induction-mediated drug interactions: in vitro assessment and clinical implications

CYP3A Activity and Expression in Nonalcoholic Fatty Liver Disease

Evaluation of Endogenous Metabolic Markers of Hepatic CYP3A Activity Using Metabolic Profiling and Midazolam Clearance

Intestinal Drug Transporter Expression and the Impact of Grapefruit Juice in Humans

Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes

Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4

Quantitative Prediction of CYP3A4 Induction: Impact of Measured, Free, and Intracellular Perpetrator Concentrations from Human Hepatocyte Induction Studies on Drug-Drug Interaction Predictions

Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI)

Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR

Transcriptional regulation of CYP3A4 by nuclear receptors in human hepatocytes under hypoxia

Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

Effects of atorvastatin metabolites on induction of drug‐metabolizing enzymes and membrane transporters through human pregnane X receptor

Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG Cells

Modeling, prediction, and in vitro in vivo correlation of CYP3A4 induction

Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats

The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/−) and TP53(−/−) cells

Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction

Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes

Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells

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