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Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127571-127571, Article 127571

2020

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Lovastatin enhances chemosensitivity of paclitaxel-resistant prostate cancer cells through inhibition of CYP2C8

Biochemical and biophysical research communications, 2022-01, Vol.589, p.85-91

2022

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In Silico Prediction of CYP2C8 Inhibition with Machine-Learning Methods

Chemical research in toxicology, 2021-08, Vol.34 (8), p.1850-1859

2021

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Evaluation of Safety and Clinically Relevant Drug–Drug Interactions with Tucatinib in Healthy Volunteers

Clinical pharmacokinetics, 2022-10, Vol.61 (10), p.1417-1426

2022

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Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects

British journal of clinical pharmacology, 2017-12, Vol.83 (12), p.2778-2788

2017

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Model‐Based Assessments of CYP‐Mediated Drug–Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development

Clinical pharmacology and therapeutics, 2018-09, Vol.104 (3), p.505-514

2018

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Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1364-1371

2016

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Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8‐Mediated Metabolism of Montelukast in Humans

Clinical pharmacology and therapeutics, 2018-09, Vol.104 (3), p.495-504

2018

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Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1217-1228

2016

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Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite

Chemico-biological interactions, 2021-04, Vol.338, p.109401, Article 109401

2021

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Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization

Arteriosclerosis, thrombosis, and vascular biology, 2016-09, Vol.36 (9), p.1919-1927

2016

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Physiologically Based Pharmacokinetic Modeling to Predict Drug–Drug Interactions with Efavirenz Involving Simultaneous Inducing and Inhibitory Effects on Cytochromes

Clinical pharmacokinetics, 2017-04, Vol.56 (4), p.409-420

2017

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Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60‐year‐old Caucasian woman with ovarian carcinoma

British journal of clinical pharmacology, 2016-02, Vol.81 (2), p.313-315

2016

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Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader

Drug metabolism and disposition, 2018-09, Vol.46 (9), p.1268-1276

2018

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Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters

Expert opinion on drug metabolism & toxicology, 2017-01, Vol.13 (1), p.83-95

2017

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CYP2C8 Genotype Significantly Alters Imatinib Metabolism in Chronic Myeloid Leukaemia Patients

Clinical pharmacokinetics, 2017-08, Vol.56 (8), p.977-985

2017

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Creation of Novel Sensitive Probe Substrate and Moderate Inhibitor Models for a Comprehensive Prediction of CYP2C8 Interactions for Tucatinib

Clinical pharmacology and therapeutics, 2024-02, Vol.115 (2), p.299-308

2024

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Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

Pharmacological reviews, 2016-01, Vol.68 (1), p.168-241

2016

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Targeting of Splice Variants of Human Cytochrome P450 2C8 (CYP2C8) to Mitochondria and Their Role in Arachidonic Acid Metabolism and Respiratory Dysfunction

The Journal of biological chemistry, 2014-10, Vol.289 (43), p.29614-29630

2014

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Pharmacokinetic Drug Interaction Studies with Enzalutamide

Clinical pharmacokinetics, 2015-10, Vol.54 (10), p.1057-1069

2015

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Interplay of UDP-Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug–Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel and Gemfibrozil

Clinical pharmacokinetics, 2024, Vol.63 (1), p.43-56

2024

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Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses

PloS one, 2016-07, Vol.11 (7), p.e0160172-e0160172

2016

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A Conserved Allosteric Site on Drug-Metabolizing CYPs: A Systematic Computational Assessment

International journal of molecular sciences, 2021-12, Vol.22 (24), p.13215

2021

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Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in‐vitro inhibition studies

Journal of pharmacy and pharmacology, 2017-12, Vol.69 (12), p.1762-1772

2017

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Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor

Lovastatin enhances chemosensitivity of paclitaxel-resistant prostate cancer cells through inhibition of CYP2C8

In Silico Prediction of CYP2C8 Inhibition with Machine-Learning Methods

Evaluation of Safety and Clinically Relevant Drug–Drug Interactions with Tucatinib in Healthy Volunteers

Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects

Model‐Based Assessments of CYP‐Mediated Drug–Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8‐Mediated Metabolism of Montelukast in Humans

Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes

Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite

Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization

Physiologically Based Pharmacokinetic Modeling to Predict Drug–Drug Interactions with Efavirenz Involving Simultaneous Inducing and Inhibitory Effects on Cytochromes

Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60‐year‐old Caucasian woman with ovarian carcinoma

Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader

Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters

CYP2C8 Genotype Significantly Alters Imatinib Metabolism in Chronic Myeloid Leukaemia Patients

Creation of Novel Sensitive Probe Substrate and Moderate Inhibitor Models for a Comprehensive Prediction of CYP2C8 Interactions for Tucatinib

Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

Targeting of Splice Variants of Human Cytochrome P450 2C8 (CYP2C8) to Mitochondria and Their Role in Arachidonic Acid Metabolism and Respiratory Dysfunction

Pharmacokinetic Drug Interaction Studies with Enzalutamide

Interplay of UDP-Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug–Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel and Gemfibrozil

Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses

A Conserved Allosteric Site on Drug-Metabolizing CYPs: A Systematic Computational Assessment

Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in‐vitro inhibition studies

Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models

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