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Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

Biochemistry (Easton), 2018-02, Vol.57 (5), p.817-826

2018

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CYP induction-mediated drug interactions: in vitro assessment and clinical implications

Pharmaceutical research, 2006-06, Vol.23 (6), p.1089-1116

Lin, Jiunn H

2006

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Peroxisome Proliferator‐Activated Receptor α Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil

Basic & clinical pharmacology & toxicology, 2017-09, Vol.121 (3), p.169-174

2017

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Bromuconazole-induced hepatotoxicity is accompanied by upregulation of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression

Toxicology mechanisms and methods, 2017-09, Vol.27 (7), p.544-550

2017

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Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006-12, Vol.844 (2), p.292-300

2006

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Brain Drug-Metabolizing Cytochrome P450 Enzymes are Active In Vivo, Demonstrated by Mechanism-Based Enzyme Inhibition

Neuropsychopharmacology (New York, N.Y.), 2009-02, Vol.34 (3), p.634-640

2009

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Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide

The Journal of biological chemistry, 2005-05, Vol.280 (20), p.19569

2005

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Biologically relevant reductions in fetal testosterone and Insl3 induced by in utero exposure to high levels of di-isononyl phthalate (DINP) in male rats

Toxicology and applied pharmacology, 2023-04, Vol.465, p.116454-116454, Article 116454

Earl Gray, L.

2023

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Beta sheet 2–alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners

Biochimica et biophysica acta, 2010-06, Vol.1804 (6), p.1285-1293

2010

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Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: A dynamic and kinetic evaluation of a putative mode-of-action

Toxicology (Amsterdam), 2012-10, Vol.300 (1-2), p.31-45

2012

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Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling

European journal of medicinal chemistry, 2022-11, Vol.242, p.114692, Article 114692

2022

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Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide

Protein engineering, design and selection, 2006-12, Vol.19 (12), p.547-554

2006

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Cytochrome P450 2B1 Mediates Complement-dependent Sublytic Injury in a Model of Membranous Nephropathy

The Journal of biological chemistry, 2010-12, Vol.285 (52), p.40901-40910

2010

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Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites

The Journal of pharmacology and experimental therapeutics, 2002-02, Vol.300 (2), p.549

2002

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Inhibitory effects of a dietary phytochemical 3,3′-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female rats

Food and chemical toxicology, 2008-07, Vol.46 (7), p.2451-2458

2008

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Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein

The Journal of pharmacology and experimental therapeutics, 2009-11, Vol.331 (2), p.392

2009

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Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism

Molecular pharmacology, 2016-04, Vol.89 (4), p.435-445

2016

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Chinese herbal formula Fuzheng Huayu alleviates CCl 4 -induced liver fibrosis in rats: a transcriptomic and proteomic analysis

Acta pharmacologica Sinica, 2018-06, Vol.39 (6), p.930

2018

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Subacute nicotine co-exposure has no effect on 2,2′,3,5′,6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat

Toxicology (Amsterdam), 2015-12, Vol.338, p.59-68

2015

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Identification of 17-α-Ethynylestradiol-Modified Active Site Peptides and Glutathione Conjugates Formed during Metabolism and Inactivation of P450s 2B1 and 2B6

Chemical research in toxicology, 2006-02, Vol.19 (2), p.279-287

2006

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Modification of Serine 360 by a Reactive Intermediate of 17-α-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6

Chemical research in toxicology, 2008-10, Vol.21 (10), p.1956-1963

2008

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Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at Ser128

The EMBO journal, 1999-10, Vol.18 (20), p.5494-5504

1999

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Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats

Toxicology (Amsterdam), 2010-04, Vol.271 (1), p.57-63

2010

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Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells

Toxicology and applied pharmacology, 2004-09, Vol.199 (3), p.332-343

2004

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Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos

Chemical research in toxicology, 2015-07, Vol.28 (7), p.1484-1495

2015

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Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

CYP induction-mediated drug interactions: in vitro assessment and clinical implications

Peroxisome Proliferator‐Activated Receptor α Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil

Bromuconazole-induced hepatotoxicity is accompanied by upregulation of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression

Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine

Brain Drug-Metabolizing Cytochrome P450 Enzymes are Active In Vivo, Demonstrated by Mechanism-Based Enzyme Inhibition

Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide

Biologically relevant reductions in fetal testosterone and Insl3 induced by in utero exposure to high levels of di-isononyl phthalate (DINP) in male rats

Beta sheet 2–alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners

Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: A dynamic and kinetic evaluation of a putative mode-of-action

Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling

Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide

Cytochrome P450 2B1 Mediates Complement-dependent Sublytic Injury in a Model of Membranous Nephropathy

Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites

Inhibitory effects of a dietary phytochemical 3,3′-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female rats

Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein

Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism

Chinese herbal formula Fuzheng Huayu alleviates CCl 4 -induced liver fibrosis in rats: a transcriptomic and proteomic analysis

Subacute nicotine co-exposure has no effect on 2,2′,3,5′,6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat

Identification of 17-α-Ethynylestradiol-Modified Active Site Peptides and Glutathione Conjugates Formed during Metabolism and Inactivation of P450s 2B1 and 2B6

Modification of Serine 360 by a Reactive Intermediate of 17-α-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6

Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at Ser128

Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats

Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells

Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos

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