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Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity

Scientific reports, 2020-11, Vol.10 (1), p.19570, Article 19570

2020

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Kinetic and Spectroscopic Investigation of the Y157F and C93G/Y157F Variants of Cysteine Dioxygenase: Dissecting the Roles of the Second-Sphere Residues C93 and Y157

Biochemistry (Easton), 2024-07, Vol.63 (13), p.1684-1696

2024

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Mining unique cysteine synthetases and computational study on thoroughly eliminating feedback inhibition through tunnel engineering

Protein science, 2024-10, Vol.33 (10), p.e5160-n/a

2024

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Probing the Cys-Tyr Cofactor Biogenesis in Cysteine Dioxygenase by the Genetic Incorporation of Fluorotyrosine

Biochemistry (Easton), 2019-04, Vol.58 (17), p.2218-2227

2019

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Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics

Molecules (Basel, Switzerland), 2020-04, Vol.25 (9), p.2064

2020

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Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation

Bioorganic & medicinal chemistry, 2015-11, Vol.23 (21), p.7053-7060

2015

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Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles

Physical chemistry chemical physics : PCCP, 2018, Vol.2 (37), p.24317-24328

2018

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Differences in the Second Coordination Sphere Tailor the Substrate Specificity and Reactivity of Thiol Dioxygenases

Accounts of chemical research, 2022-09, Vol.55 (17), p.2480-2490

2022

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Quantum mechanics/molecular mechanics studies of the mechanism of cysteine protease inhibition by peptidyl-2,3-epoxyketones

Physical chemistry chemical physics : PCCP, 2017, Vol.19 (20), p.12740-12748

2017

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Proximity-Enabled Protein Crosslinking through Genetically Encoding Haloalkane Unnatural Amino Acids

Angewandte Chemie (International ed.), 2014-02, Vol.53 (8), p.2190-2193

International ed. in English, 2014

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Enhancing Tris(pyrazolyl)borate‐Based Models of Cysteine/Cysteamine Dioxygenases through Steric Effects: Increased Reactivities, Full Product Characterization and Hints to Initial Superoxide Formation

Chemistry : a European journal, 2020-09, Vol.26 (51), p.11851-11861

2020

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Allosteric Site Inhibitor Disrupting Auto-Processing of Malarial Cysteine Proteases

Scientific reports, 2018-11, Vol.8 (1), p.16193-15, Article 16193

2018

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Substitution-Induced Mechanistic Switching in S N Ar-Warheads for Cysteine Proteases

Molecules (Basel, Switzerland), 2024-06, Vol.29 (11)

2024

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Cofactor Biogenesis in Cysteamine Dioxygenase: C−F Bond Cleavage with Genetically Incorporated Unnatural Tyrosine

Angewandte Chemie International Edition, 2018-07, Vol.57 (27), p.8149-8153

International ed. in English, 2018

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Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity

Nature methods, 2013-09, Vol.10 (9), p.885-888

2013

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The 3-His Metal Coordination Site Promotes the Coupling of Oxygen Activation to Cysteine Oxidation in Cysteine Dioxygenase

Biochemistry (Easton), 2020-06, Vol.59 (21), p.2022-2031

2020

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Effects of Cysteine Proteases on the Structural and Mechanical Properties of Collagen Fibers

The Journal of biological chemistry, 2013-02, Vol.288 (8), p.5940-5950

2013

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SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (33), p.10348-10353

2015

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Substrate Specificity in Thiol Dioxygenases

Biochemistry (Easton), 2019-05, Vol.58 (19), p.2398-2407

2019

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Spectroscopic analysis of the mammalian enzyme cysteine dioxygenase

Methods in enzymology, 2023, Vol.682, p.101-135

2023

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Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action

Journal of the American Chemical Society, 2018-08, Vol.140 (30), p.9478-9485

2018

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Building and Breaking Bonds via a Compact S‐Propargyl‐Cysteine to Chemically Control Enzymes and Modify Proteins

Angewandte Chemie International Edition, 2018-09, Vol.57 (39), p.12702-12706

International ed. in English, 2018

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Semienzymatic Cyclization of Disulfide-rich Peptides Using Sortase A

The Journal of biological chemistry, 2014-03, Vol.289 (10), p.6627-6638

2014

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In Situ Cyclization of Native Proteins: Structure‐Based Design of a Bicyclic Enzyme

Angewandte Chemie International Edition, 2018-08, Vol.57 (35), p.11164-11170

International ed. in English, 2018

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The Crystal Structure Analysis of Group B Streptococcus Sortase C1: A Model for the “Lid” Movement upon Substrate Binding

Journal of molecular biology, 2011-12, Vol.414 (4), p.563-577

2011

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Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity

Kinetic and Spectroscopic Investigation of the Y157F and C93G/Y157F Variants of Cysteine Dioxygenase: Dissecting the Roles of the Second-Sphere Residues C93 and Y157

Mining unique cysteine synthetases and computational study on thoroughly eliminating feedback inhibition through tunnel engineering

Probing the Cys-Tyr Cofactor Biogenesis in Cysteine Dioxygenase by the Genetic Incorporation of Fluorotyrosine

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics

Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation

Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles

Differences in the Second Coordination Sphere Tailor the Substrate Specificity and Reactivity of Thiol Dioxygenases

Quantum mechanics/molecular mechanics studies of the mechanism of cysteine protease inhibition by peptidyl-2,3-epoxyketones

Proximity-Enabled Protein Crosslinking through Genetically Encoding Haloalkane Unnatural Amino Acids

Enhancing Tris(pyrazolyl)borate‐Based Models of Cysteine/Cysteamine Dioxygenases through Steric Effects: Increased Reactivities, Full Product Characterization and Hints to Initial Superoxide Formation

Allosteric Site Inhibitor Disrupting Auto-Processing of Malarial Cysteine Proteases

Substitution-Induced Mechanistic Switching in S N Ar-Warheads for Cysteine Proteases

Cofactor Biogenesis in Cysteamine Dioxygenase: C−F Bond Cleavage with Genetically Incorporated Unnatural Tyrosine

Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity

The 3-His Metal Coordination Site Promotes the Coupling of Oxygen Activation to Cysteine Oxidation in Cysteine Dioxygenase

Effects of Cysteine Proteases on the Structural and Mechanical Properties of Collagen Fibers

SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses

Substrate Specificity in Thiol Dioxygenases

Spectroscopic analysis of the mammalian enzyme cysteine dioxygenase

Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action

Building and Breaking Bonds via a Compact S‐Propargyl‐Cysteine to Chemically Control Enzymes and Modify Proteins

Semienzymatic Cyclization of Disulfide-rich Peptides Using Sortase A

In Situ Cyclization of Native Proteins: Structure‐Based Design of a Bicyclic Enzyme

The Crystal Structure Analysis of Group B Streptococcus Sortase C1: A Model for the “Lid” Movement upon Substrate Binding

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